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Precision oncology is currently limited by the small-N, large-P paradox, where high-dimensional genomic data is abundant but pharmacological response samples are sparse. While deep learning achieves predictive accuracy, it frequently fails…

Quantitative Methods · Quantitative Biology 2026-05-11 Christopher Baker , Karen Rafferty , Hui Wang

Melanoma diagnosed and treated in its early stages can increase the survival rate. A projected increase in skin cancer incidents and a dearth of dermatopathologists have emphasized the need for computational pathology (CPATH) systems. CPATH…

Image and Video Processing · Electrical Eng. & Systems 2023-11-07 Neel Kanwal , Roger Amundsen , Helga Hardardottir , Luca Tomasetti , Erling Sandoy Undersrud , Emiel A. M. Janssen , Kjersti Engan

Purpose: A major barrier to the implementation of artificial intelligence for medical applications is the lack of explainability and high confidence for incorrect decisions, specifically with out-of-domain samples. We propose a…

Computer Vision and Pattern Recognition · Computer Science 2026-01-22 Mikyla K. Bowen , Jesse W. Wilson

Although melanoma occurs more rarely than several other skin cancers, patients' long term survival rate is extremely low if the diagnosis is missed. Diagnosis is complicated by a high discordance rate among pathologists when distinguishing…

Pathologists have a rich vocabulary with which they can describe all the nuances of cellular morphology. In their world, there is a natural pairing of images and words. Recent advances demonstrate that machine learning models can now be…

Machine Learning · Computer Science 2022-07-14 Simon M. Thomas , James G. Lefevre , Glenn Baxter , Nicholas A. Hamilton

Although melanoma occurs more rarely than several other skin cancers, patients' long term survival rate is extremely low if the diagnosis is missed. Diagnosis is complicated by a high discordance rate among pathologists when distinguishing…

Computer Vision and Pattern Recognition · Computer Science 2022-10-11 Sean Grullon , Vaughn Spurrier , Jiayi Zhao , Corey Chivers , Yang Jiang , Kiran Motaparthi , Michael Bonham , Julianna Ianni

Melanoma skin cancer is one of the most dangerous and life-threatening cancer. Exposure to ultraviolet rays may damage the skin cell's DNA, which causes melanoma skin cancer. However, it is difficult to detect and classify melanoma and…

Computer Vision and Pattern Recognition · Computer Science 2023-11-21 N. I. Md. Ashafuddula , Rafiqul Islam

The accurate classification of lymphoma subtypes using hematoxylin and eosin (H&E)-stained tissue is complicated by the wide range of morphological features these cancers can exhibit. We present LymphoML - an interpretable machine learning…

Medical image classification is a critical problem for healthcare, with the potential to alleviate the workload of doctors and facilitate diagnoses of patients. However, two challenges arise when deploying deep learning models to real-world…

Computer Vision and Pattern Recognition · Computer Science 2023-10-06 An Yan , Yu Wang , Yiwu Zhong , Zexue He , Petros Karypis , Zihan Wang , Chengyu Dong , Amilcare Gentili , Chun-Nan Hsu , Jingbo Shang , Julian McAuley

Skin cancer is a serious worldwide health issue, precise and early detection is essential for better patient outcomes and effective treatment. In this research, we use modern deep learning methods and explainable artificial intelligence…

Image and Video Processing · Electrical Eng. & Systems 2023-12-19 Faysal Mahmud , Md. Mahin Mahfiz , Md. Zobayer Ibna Kabir , Yusha Abdullah

In the context of image classification, Concept Bottleneck Models (CBMs) first embed images into a set of human-understandable concepts, followed by an intrinsically interpretable classifier that predicts labels based on these intermediate…

Computer Vision and Pattern Recognition · Computer Science 2025-10-02 Haifei Zhang , Patrick Barry , Eduardo Brandao

Deep Neural Networks have often been called the black box because of the complex, deep architecture and non-transparency presented by the inner layers. There is a lack of trust to use Artificial Intelligence in critical and high-precision…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Frincy Clement , Ji Yang , Irene Cheng

Melanoma, one of the deadliest types of skin cancer, accounts for thousands of fatalities globally. The bluish, blue-whitish, or blue-white veil (BWV) is a critical feature for diagnosing melanoma, yet research into detecting BWV in…

Computer Vision and Pattern Recognition · Computer Science 2025-07-11 M. A. Rasel , Sameem Abdul Kareem , Zhenli Kwan , Shin Shen Yong , Unaizah Obaidellah

In this paper, we studied extensively on different deep learning based methods to detect melanoma and skin lesion cancers. Melanoma, a form of malignant skin cancer is very threatening to health. Proper diagnosis of melanoma at an earlier…

Computer Vision and Pattern Recognition · Computer Science 2019-01-31 Md Ashraful Alam Milton

Melanoma is a type of skin cancer developed from melanocytes. It is one of the most lethal types of cancer, accounting for approximately 75% of skin cancer deaths. Late stage melanoma is very difficult to treat, since the cancer cells are…

Quantitative Methods · Quantitative Biology 2018-11-28 Xue Teng , Fuad Gwadry , Haley McConkey , Scott Ernst , Femida Gwadry-Sridhar

Although explainability is essential in the clinical diagnosis, most deep learning models still function as black boxes without elucidating their decision-making process. In this study, we investigate the explainable model development that…

Computer Vision and Pattern Recognition · Computer Science 2024-09-20 Yunhe Gao , Difei Gu , Mu Zhou , Dimitris Metaxas

Glaucoma is the second driving reason for partial or complete blindness among all the visual deficiencies which mainly occurs because of excessive pressure in the eye due to anxiety or depression which damages the optic nerve and creates…

Computer Vision and Pattern Recognition · Computer Science 2022-10-10 Touhidul Islam Chayan , Anita Islam , Eftykhar Rahman , Md. Tanzim Reza , Tasnim Sakib Apon , MD. Golam Rabiul Alam

This paper claims that machine learning models deployed in high stakes domains such as medicine must be interpretable, shareable, reproducible and accountable. We argue that these principles should form the foundational design criteria for…

Machine Learning · Computer Science 2025-08-25 Ayyüce Begüm Bektaş , Mithat Gönen

Convolutional neural networks (CNNs) deliver exceptional results for computer vision, including medical image analysis. With the growing number of available architectures, picking one over another is far from obvious. Existing art suggests…

Computer Vision and Pattern Recognition · Computer Science 2019-04-30 Fábio Perez , Sandra Avila , Eduardo Valle

Deep learning methods, in particular convolutional neural networks, have emerged as a powerful tool in medical image computing tasks. While these complex models provide excellent performance, their black-box nature may hinder real-world…

Image and Video Processing · Electrical Eng. & Systems 2022-10-18 Yuzhe Lu , Adam Perer