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Deep learning has the potential to automate many clinically useful tasks in medical imaging. However translation of deep learning into clinical practice has been hindered by issues such as lack of the transparency and interpretability in…

Image and Video Processing · Electrical Eng. & Systems 2022-05-04 Charles Lu , Andreanne Lemay , Ken Chang , Katharina Hoebel , Jayashree Kalpathy-Cramer

Machine learning methods have shown large potential for the automatic early diagnosis of Alzheimer's Disease (AD). However, some machine learning methods based on imaging data have poor interpretability because it is usually unclear how…

Deep learning methods have been very effective for a variety of medical diagnostic tasks and has even beaten human experts on some of those. However, the black-box nature of the algorithms has restricted clinical use. Recent explainability…

Computer Vision and Pattern Recognition · Computer Science 2020-05-29 Amitojdeep Singh , Sourya Sengupta , Vasudevan Lakshminarayanan

In visual object classification, humans often justify their choices by comparing objects to prototypical examples within that class. We may therefore increase the interpretability of deep learning models by imbuing them with a similar style…

Computer Vision and Pattern Recognition · Computer Science 2023-10-26 Ayodeji Ijishakin , Ahmed Abdulaal , Adamos Hadjivasiliou , Sophie Martin , James Cole

Melanoma, a malignant form of skin cancer is very threatening to life. Diagnosis of melanoma at an earlier stage is highly needed as it has a very high cure rate. Benign and malignant forms of skin cancer can be detected by analyzing the…

Computer Vision and Pattern Recognition · Computer Science 2017-03-14 P. Mirunalini , Aravindan Chandrabose , Vignesh Gokul , S. M. Jaisakthi

Deep learning methods for ophthalmic diagnosis have shown considerable success in tasks like segmentation and classification. However, their widespread application is limited due to the models being opaque and vulnerable to making a wrong…

Image and Video Processing · Electrical Eng. & Systems 2021-01-29 Amitojdeep Singh , Sourya Sengupta , Mohammed Abdul Rasheed , Varadharajan Jayakumar , Vasudevan Lakshminarayanan

Brain tumors represent one of the most critical neurological conditions, where early and accurate diagnosis is directly correlated with patient survival rates. Manual interpretation of Magnetic Resonance Imaging (MRI) scans is…

Computer Vision and Pattern Recognition · Computer Science 2026-04-24 Chinedu Emmanuel Mbonu , Tochukwu Sunday Belonwu , Okwuchukwu Ejike Chukwuogo , Kenechukwu Sylvanus Anigbogu

Machine learning accelerates molecular property prediction, yet state-of-the-art Large Language Models and Graph Neural Networks operate as black boxes. In drug discovery, where safety is critical, this opacity risks masking false…

Machine Learning · Computer Science 2026-03-03 Oscar Rivera , Ziqing Wang , Matthieu Dagommer , Abhishek Pandey , Kaize Ding

Dermatologists often diagnose or rule out early melanoma by evaluating the follow-up dermoscopic images of skin lesions. However, existing algorithms for early melanoma diagnosis are developed using single time-point images of lesions.…

Image and Video Processing · Electrical Eng. & Systems 2021-10-13 Zhen Yu , Jennifer Nguyen , Toan D Nguyen , John Kelly , Catriona Mclean , Paul Bonnington , Lei Zhang , Victoria Mar , Zongyuan Ge

Electrocardiogram (ECG) diagnosis remains challenging due to limited labeled data and the need to capture subtle yet clinically meaningful variations in rhythm and morphology. We present CREMA (Contrastive Regularized Masked Autoencoder), a…

Machine Learning · Computer Science 2025-08-22 Junho Song , Jong-Hwan Jang , DongGyun Hong , Joon-myoung Kwon , Yong-Yeon Jo

Reliable and interpretable decision-making is essential in medical imaging, where diagnostic outcomes directly influence patient care. Despite advances in deep learning, most medical AI systems operate as opaque black boxes, providing…

Computer Vision and Pattern Recognition · Computer Science 2026-04-16 Pirzada Suhail , Aditya Anand , Amit Sethi

Skin lesion datasets consist predominantly of normal samples with only a small percentage of abnormal ones, giving rise to the class imbalance problem. Also, skin lesion images are largely similar in overall appearance owing to the low…

Image and Video Processing · Electrical Eng. & Systems 2020-07-29 Hasib Zunair , A. Ben Hamza

Cutaneous malignancies demand early detection for favorable outcomes, yet current diagnostics suffer from inter-observer variability and access disparities. While AI shows promise, existing dermatological systems are limited by homogeneous…

Computer Vision and Pattern Recognition · Computer Science 2025-10-09 Sher Khan , Raz Muhammad , Adil Hussain , Muhammad Sajjad , Muhammad Rashid

Background \& purpose: The recent emergence of neural networks models for the analysis of breast images has been a breakthrough in computer aided diagnostic. This approach was not yet developed in Contrast Enhanced Spectral Mammography…

Image and Video Processing · Electrical Eng. & Systems 2022-08-01 Clément Jailin , Pablo Milioni , Zhijin Li , Răzvan Iordache , Serge Muller

Recent brain tumor classification methods often report high accuracy but rely on deep, over-parameterized architectures with limited interpretability, making it difficult to determine whether predictions are driven by tumor-relevant…

Image and Video Processing · Electrical Eng. & Systems 2026-03-24 Rajan Das Gupta , Md Imrul Hasan Showmick , Lei Wei , Mushfiqur Rahman Abir , Shanjida Akter , Md. Yeasin Rahat , Md. Jakir Hossen

The incidence of malignant melanoma continues to increase worldwide. This cancer can strike at any age; it is one of the leading causes of loss of life in young persons. Since this cancer is visible on the skin, it is potentially detectable…

Computer Vision and Pattern Recognition · Computer Science 2016-01-29 Nabin K. Mishra , M. Emre Celebi

Building trustworthy clinical AI systems requires not only accurate predictions but also transparent, biologically grounded explanations. We present \texttt{DiagnoLLM}, a hybrid framework that integrates Bayesian deconvolution, eQTL-guided…

Artificial Intelligence · Computer Science 2025-11-18 Bowen Xu , Xinyue Zeng , Jiazhen Hu , Tuo Wang , Adithya Kulkarni

Knowledge transfer impacts the performance of deep learning -- the state of the art for image classification tasks, including automated melanoma screening. Deep learning's greed for large amounts of training data poses a challenge for…

Computer Vision and Pattern Recognition · Computer Science 2018-03-28 Afonso Menegola , Michel Fornaciali , Ramon Pires , Flávia Vasques Bittencourt , Sandra Avila , Eduardo Valle

Melanoma is a malignant tumor that originates from skin cell lesions. Accurate and efficient segmentation of skin lesions is essential for quantitative analysis but remains a challenge due to blurred lesion boundaries, gradual color…

Image and Video Processing · Electrical Eng. & Systems 2025-07-03 Saqib Qamar , Syed Furqan Qadri , Roobaea Alroobaea , Goram Mufarah M Alshmrani , Richard Jiang

Skin lesion segmentation plays a crucial role in the computer-aided diagnosis of melanoma. Deep Learning models have shown promise in accurately segmenting skin lesions, but their widespread adoption in real-life clinical settings is…

Image and Video Processing · Electrical Eng. & Systems 2023-11-01 Shankara Narayanan , Sikha OK , Raul Benitez
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