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Related papers: STAR-GO: Improving Protein Function Prediction by …

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Unsupervised semantic segmentation aims to discover and localize semantically meaningful categories within image corpora without any form of annotation. To solve this task, algorithms must produce features for every pixel that are both…

Computer Vision and Pattern Recognition · Computer Science 2022-03-17 Mark Hamilton , Zhoutong Zhang , Bharath Hariharan , Noah Snavely , William T. Freeman

The proliferation of AI-powered search engines has shifted information discovery from traditional link-based retrieval to direct answer generation with selective source citation, creating new challenges for content visibility. While…

Computation and Language · Computer Science 2026-04-01 Junwei Yu , Mufeng Yang , Yepeng Ding , Hiroyuki Sato

The dynamic nature of proteins is crucial for determining their biological functions and properties, for which Monte Carlo (MC) and molecular dynamics (MD) simulations stand as predominant tools to study such phenomena. By utilizing…

Quantitative Methods · Quantitative Biology 2024-03-13 Jiarui Lu , Bozitao Zhong , Zuobai Zhang , Jian Tang

Understanding protein structure-function relationships is a key challenge in computational biology, with applications across the biotechnology and pharmaceutical industries. While it is known that protein structure directly impacts protein…

Biomolecules · Quantitative Biology 2020-11-02 Nicolas Swenson , Aditi S. Krishnapriyan , Aydin Buluc , Dmitriy Morozov , Katherine Yelick

Recent advances in protein function prediction exploit graph-based deep learning approaches to correlate the structural and topological features of proteins with their molecular functions. However, proteins in vivo are not static but…

Biomolecules · Quantitative Biology 2022-11-22 Yuan Chiang , Wei-Han Hui , Shu-Wei Chang

We applied machine learning to predict whether a gene is involved in axon regeneration. We extracted 31 features from different databases and trained five machine learning models. Our optimal model, a Random Forest Classifier with 50…

Machine Learning · Computer Science 2019-09-27 Haoze Wu , Yangyu Zhou

We are now witnessing significant progress of deep learning methods in a variety of tasks (or datasets) of proteins. However, there is a lack of a standard benchmark to evaluate the performance of different methods, which hinders the…

Machine Learning · Computer Science 2022-09-20 Minghao Xu , Zuobai Zhang , Jiarui Lu , Zhaocheng Zhu , Yangtian Zhang , Chang Ma , Runcheng Liu , Jian Tang

Real-world ecommerce recommender systems must deliver relevant items under strict tens-of-milliseconds latency constraints despite challenges such as cold-start products, rapidly shifting user intent, and dynamic context including…

Information Retrieval · Computer Science 2025-12-16 Han Chen , Steven Zhu , Yingrui Li

Representation learning is a critical ingredient for natural language processing systems. Recent Transformer language models like BERT learn powerful textual representations, but these models are targeted towards token- and sentence-level…

Computation and Language · Computer Science 2020-05-21 Arman Cohan , Sergey Feldman , Iz Beltagy , Doug Downey , Daniel S. Weld

Time series classification is a task of paramount importance, as this kind of data often arises in safety-critical applications. However, it is typically tackled with black-box deep learning methods, making it hard for humans to understand…

Machine Learning · Computer Science 2025-11-07 Irene Ferfoglia , Simone Silvetti , Gaia Saveri , Laura Nenzi , Luca Bortolussi

Vision-language models (VLMs) have made significant strides in reasoning, yet they often struggle with complex multimodal tasks and tend to generate overly verbose outputs. A key limitation is their reliance on chain-of-thought (CoT)…

Artificial Intelligence · Computer Science 2026-02-11 Chen Li , Han Zhang , Zhantao Yang , Fangyi Chen , Zihan Wang , Anudeepsekhar Bolimera , Marios Savvides

Protein representation learning is critical for numerous biological tasks. Recently, large transformer-based protein language models (pLMs) pretrained on large scale protein sequences have demonstrated significant success in sequence-based…

Machine Learning · Computer Science 2025-08-12 Xuefeng Liu , Songhao Jiang , Chih-chan Tien , Jinbo Xu , Rick Stevens

Recent advances in AI for science have highlighted the power of contrastive learning in bridging heterogeneous biological data modalities. Building on this paradigm, we propose HIPPO (HIerarchical Protein-Protein interaction prediction…

Machine Learning · Computer Science 2025-08-05 Shiyi Liu , Buwen Liang , Yuetong Fang , Zixuan Jiang , Renjing Xu

Optimizing complex systems, from discovering therapeutic drugs to designing high-performance materials, remains a fundamental challenge across science and engineering, as the underlying rules are often unknown and costly to evaluate.…

Machine Learning · Computer Science 2026-01-13 Tailin Zhou , Zhilin Chen , Wenlong Lyu , Zhitang Chen , Danny H. K. Tsang , Jun Zhang

Protein structure tokenization converts 3D structures into discrete or vectorized representations, enabling the integration of structural and sequence data. Despite many recent works on structure tokenization, the properties of the…

Machine Learning · Computer Science 2025-11-14 Zijing Liu , Bin Feng , He Cao , Yu Li

The capability of accurate prediction of protein functions and properties is essential in the biotechnology industry, e.g. drug development and artificial protein synthesis, etc. The main challenges of protein function prediction are the…

Quantitative Methods · Quantitative Biology 2021-12-02 Wei-Cheng Tseng , Po-Han Chi , Jia-Hua Wu , Min Sun

Zero-shot recognition aims to classify an image by selecting the most compatible label description from a set of candidate classes without any task-specific supervision. In fine-grained settings, however, the relevant evidence often lies in…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Junyi Hu , Qiji Zhou , Lei Zhang , Yue Zhang

Schema matching is a critical task in data integration, particularly in the medical domain where disparate Electronic Health Record (EHR) systems must be aligned to standard models like OMOP CDM. While Large Language Models (LLMs) have…

Artificial Intelligence · Computer Science 2025-12-02 Mingyu Jeon , Jaeyoung Suh , Suwan Cho

Generative recommendation has recently emerged as a promising paradigm for sequential recommendation. It formulates the task as an autoregressive generation process, predicting tokens of the next item conditioned on user interaction…

Information Retrieval · Computer Science 2026-05-29 Yuanqing Yu , Yifan Wang , Weizhi Ma , Zhiqiang Guo , Min Zhang

We present STARC (Structured Annotations for Reading Comprehension), a new annotation framework for assessing reading comprehension with multiple choice questions. Our framework introduces a principled structure for the answer choices and…

Computation and Language · Computer Science 2020-05-01 Yevgeni Berzak , Jonathan Malmaud , Roger Levy
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