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One of the primary computational requirements of a cellular system is the ability to transfer information between spatially separated components. To accomplish this, biology uses diverse physical channels including production or release of…

Biological Physics · Physics 2023-08-11 Samuel Bryant , Benjamin Machta

This paper deals with the data-driven synthesis of dissipative linear systems in discrete time. We collect finitely many noisy data samples with which we synthesise a controller that makes all systems that explain the data dissipative with…

Optimization and Control · Mathematics 2025-01-31 Encho T. Nguyen , Henk J. van Waarde

We derive a universal bound on the efficiency with which "dissipated" work can generate distinguishable changes in a quantum many-body state at a finite temperature, as quantified by the quantum Fisher information. The bound follows solely…

Strongly Correlated Electrons · Physics 2026-02-06 Debanjan Chowdhury

Biological molecular machines are bifunctional enzymes that catalyze two processes: one donating free energy and the other accepting it. Recent studies show that most protein enzymes have rich stochastic dynamics of transitions between the…

Biological Physics · Physics 2023-02-02 Michal Kurzynski , Przemyslaw Chelminiak

In this work we focus on how noise propagates in biochemical reaction networks and affects sensitivities of the system. We discover that the stochastic fluctuations can enhance sensitivities in one region of the value of control parameters…

Molecular Networks · Quantitative Biology 2008-06-24 Kyung Hyuk Kim , Hong Qian , Herbert M. Sauro

This paper is framed in a series of studies on attraction-repulsion chemotaxis models combining different effects: nonlinear diffusion and sensitivities and logistic sources, for the dynamics of the cell density, and consumption and/or…

Analysis of PDEs · Mathematics 2023-05-17 Tongxing Li , Silvia Frassu , Giuseppe Viglialoro

Sensors embedded in mobile smart devices can monitor users' activity with high accuracy to provide a variety of services to end-users ranging from precise geolocation, health monitoring, and handwritten word recognition. However, this…

Cryptography and Security · Computer Science 2022-05-16 Rahat Masood , Wing Yan Cheng , Dinusha Vatsalan , Deepak Mishra , Hassan Jameel Asghar , Mohamed Ali Kaafar

We examine a biomolecular machine involving a driven, observable process coupled to a hidden process in a kinetically cooperative manner. A stochastic thermodynamics framework is employed to analyze a fluctuation theorem for the…

Statistical Mechanics · Physics 2025-11-14 D. Evan Piephoff , Jianshu Cao

In recent years, diffusion models trained on equilibrium molecular distributions have proven effective for sampling biomolecules. Beyond direct sampling, the score of such a model can also be used to derive the forces that act on molecular…

Machine Learning · Computer Science 2026-01-15 Michael Plainer , Hao Wu , Leon Klein , Stephan Günnemann , Frank Noé

We establish the fluctuation theorem in the presence of information exchange between a nonequilibrium system and other degrees of freedom such as an observer and a feedback controller, where the amount of information exchange is added to…

Statistical Mechanics · Physics 2015-06-05 Takahiro Sagawa , Masahito Ueda

The fluctuation theorem for entropy production is a remarkable symmetry of the distribution of produced entropy that holds universally in non-equilibrium steady states with Markovian dynamics. However, in systems with slow degrees of…

Statistical Mechanics · Physics 2018-02-21 Matthias Uhl , Patrick Pietzonka , Udo Seifert

Presented with sensory challenges, living cells employ extensive noisy, fluctuating signalling and communication among themselves to compute a physiologically proper response which often results in symmetry breaking. We propose, based on…

Biological Physics · Physics 2022-06-17 Dean Korošak , Andraž Stožer , Marjan Slak Rupnik

Biological and living systems process information across spatiotemporal scales, exhibiting the hallmark ability to constantly modulate their behavior to ever-changing and complex environments. In the presence of repeated stimuli, a…

Statistical Mechanics · Physics 2025-02-04 Giorgio Nicoletti , Matteo Bruzzone , Samir Suweis , Marco Dal Maschio , Daniel Maria Busiello

Allostery is a fundamental mechanism of protein regulation and is commonly interpreted as modulating enzymatic activity or product abundance. Here we show that this view is incomplete. Using a stochastic model of allosteric regulation…

Molecular Networks · Quantitative Biology 2026-01-08 Pedro Pessoa , Steve Pressé , S. Banu Ozkan

We study the compressive diffusion strategies over distributed networks based on the diffusion implementation and adaptive extraction of the information from the compressed diffusion data. We demonstrate that one can achieve a comparable…

Systems and Control · Computer Science 2015-06-18 Muhammed O. Sayin , Suleyman S. Kozat

Versatile, ultracompact, easy-to-handle, high-sensitivity sensors are compelling tools for in situ pivotal applications, such as medical diagnostics, security and safety assessments, and environmental control. In this work, we combine…

Systems driven away from thermal equilibrium constantly deliver entropy to their environment. Determining this entropy production requires detailed information about the system's internal states and dynamics. However, in most practical…

Statistical Mechanics · Physics 2017-10-03 Gili Bisker , Matteo Polettini , Todd R. Gingrich , Jordan M. Horowitz

A closed-loop control of a reaction-diffusion type process is introduced. The control system consist of a finite number of control and measurement devices. The measurement devices collect information about the current state of the process.…

Optimization and Control · Mathematics 2013-06-28 Grzegorz Dudziuk

In this paper, we address the problem of simultaneous classification and estimation of hidden parameters in a sensor network with communications constraints. In particular, we consider a network of noisy sensors which measure a common…

Multiagent Systems · Computer Science 2012-06-19 Fabio Fagnani , Sophie M. Fosson , Chiara Ravazzi

We study the dynamics of a simple adaptive system in the presence of noise and periodic damping. The system is composed by two paths connecting a source and a sink, the dynamics is governed by equations that usually describe food search of…

Statistical Mechanics · Physics 2021-12-23 Frederic Folz , Kurt Mehlhorn , Giovanna Morigi