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Leveraging the Segment Anything Model (SAM) for medical image segmentation remains challenging due to its limited adaptability across diverse medical domains. Although fine-tuned variants, such as MedSAM, improve performance in scenarios…

Computer Vision and Pattern Recognition · Computer Science 2026-01-06 Jianghao Wu , Yicheng Wu , Yutong Xie , Wenjia Bai , You Zhang , Feilong Tang , Yulong Li , Imran Razzak , Daniel F Schmidt , Yasmeen George

Foundation medical segmentation models, with MedSAM being the most popular, have achieved promising performance across organs and lesions. However, MedSAM still suffers from compromised performance on specific lesions with intricate…

Quantitative Methods · Quantitative Biology 2025-07-16 Kecheng Chen , Xinyu Luo , Tiexin Qin , Jie Liu , Hui Liu , Victor Ho Fun Lee , Hong Yan , Haoliang Li

While the Segment Anything Model (SAM) excels in semantic segmentation for general-purpose images, its performance significantly deteriorates when applied to medical images, primarily attributable to insufficient representation of medical…

Computer Vision and Pattern Recognition · Computer Science 2023-11-07 Yiming Zhang , Tianang Leng , Kun Han , Xiaohui Xie

The Segment Anything Model (SAM), a foundation model for general image segmentation, has demonstrated impressive zero-shot performance across numerous natural image segmentation tasks. However, SAM's performance significantly declines when…

Computer Vision and Pattern Recognition · Computer Science 2023-09-19 Cheng Chen , Juzheng Miao , Dufan Wu , Zhiling Yan , Sekeun Kim , Jiang Hu , Aoxiao Zhong , Zhengliang Liu , Lichao Sun , Xiang Li , Tianming Liu , Pheng-Ann Heng , Quanzheng Li

In this paper, we address the challenge of image resolution variation for the Segment Anything Model (SAM). SAM, known for its zero-shot generalizability, exhibits a performance degradation when faced with datasets with varying image sizes.…

Computer Vision and Pattern Recognition · Computer Science 2024-03-21 Yiran Song , Qianyu Zhou , Xiangtai Li , Deng-Ping Fan , Xuequan Lu , Lizhuang Ma

The Segment Anything Model (SAM) has achieved remarkable successes in the realm of natural image segmentation, but its deployment in the medical imaging sphere has encountered challenges. Specifically, the model struggles with medical…

Computer Vision and Pattern Recognition · Computer Science 2024-08-02 Shreyank N Gowda , David A. Clifton

Vision foundation models like the Segment Anything Model (SAM), pretrained on large-scale natural image datasets, often struggle in medical image segmentation due to a lack of domain-specific adaptation. In clinical practice, fine-tuning…

Computer Vision and Pattern Recognition · Computer Science 2025-11-03 Zelin Liu , Sicheng Dong , Bocheng Li , Yixuan Yang , Jiacheng Ruan , Chenxu Zhou , Suncheng Xiang

Segmentation is a fundamental problem in surgical scene analysis using artificial intelligence. However, the inherent data scarcity in this domain makes it challenging to adapt traditional segmentation techniques for this task. To tackle…

Computer Vision and Pattern Recognition · Computer Science 2023-08-08 Jay N. Paranjape , Nithin Gopalakrishnan Nair , Shameema Sikder , S. Swaroop Vedula , Vishal M. Patel

Source-free test-time adaptation for medical image segmentation aims to enhance the adaptability of segmentation models to diverse and previously unseen test sets of the target domain, which contributes to the generalizability and…

Computer Vision and Pattern Recognition · Computer Science 2023-10-19 Yanyu Ye , Zhenxi Zhang , Wei Wei , Chunna Tian

The success of large language models has inspired the computer vision community to explore image segmentation foundation model that is able to zero/few-shot generalize through prompt engineering. Segment-Anything(SAM), among others, is the…

Computer Vision and Pattern Recognition · Computer Science 2024-04-11 Haojie Zhang , Yongyi Su , Xun Xu , Kui Jia

Vision foundation models have achieved remarkable progress across various image analysis tasks. In the image segmentation task, foundation models like the Segment Anything Model (SAM) enable generalizable zero-shot segmentation through…

Computer Vision and Pattern Recognition · Computer Science 2025-01-17 Xingxin He , Yifan Hu , Zhaoye Zhou , Mohamed Jarraya , Fang Liu

Test time Adaptation is a promising approach for mitigating domain shift in medical image segmentation; however, current evaluations remain limited in terms of modality coverage, task diversity, and methodological consistency. We present…

Computer Vision and Pattern Recognition · Computer Science 2025-12-03 Wenjing Yu , Shuo Jiang , Yifei Chen , Shuo Chang , Yuanhan Wang , Beining Wu , Jie Dong , Mingxuan Liu , Shenghao Zhu , Feiwei Qin , Changmiao Wang , Qiyuan Tian

Segmentation in medical imaging is a critical component for the diagnosis, monitoring, and treatment of various diseases and medical conditions. Presently, the medical segmentation landscape is dominated by numerous specialized deep…

The recent Segment Anything Model (SAM) has demonstrated remarkable zero-shot capability and flexible geometric prompting in general image segmentation. However, SAM often struggles when handling various unconventional images, such as…

Computer Vision and Pattern Recognition · Computer Science 2024-07-17 Aoran Xiao , Weihao Xuan , Heli Qi , Yun Xing , Ruijie Ren , Xiaoqin Zhang , Ling Shao , Shijian Lu

Segment anything model (SAM) has emerged as the leading approach for zero-shot learning in segmentation tasks, offering the advantage of avoiding pixel-wise annotations. It is particularly appealing in medical image segmentation, where the…

Image and Video Processing · Electrical Eng. & Systems 2023-12-29 Ziyi Huang , Hongshan Liu , Haofeng Zhang , Xueshen Li , Haozhe Liu , Fuyong Xing , Andrew Laine , Elsa Angelini , Christine Hendon , Yu Gan

This paper addresses the domain adaptation challenge for semantic segmentation in medical imaging. Despite the impressive performance of recent foundational segmentation models like SAM on natural images, they struggle with medical domain…

Computer Vision and Pattern Recognition · Computer Science 2025-01-14 Javier Gamazo Tejero , Moritz Schmid , Pablo Márquez Neila , Martin S. Zinkernagel , Sebastian Wolf , Raphael Sznitman

Recent advancements in biomedical image analysis have been significantly driven by the Segment Anything Model (SAM). This transformative technology, originally developed for general-purpose computer vision, has found rapid application in…

Computer Vision and Pattern Recognition · Computer Science 2024-01-17 Ho Hin Lee , Yu Gu , Theodore Zhao , Yanbo Xu , Jianwei Yang , Naoto Usuyama , Cliff Wong , Mu Wei , Bennett A. Landman , Yuankai Huo , Alberto Santamaria-Pang , Hoifung Poon

Test-time adaptation (TTA) has emerged as a promising paradigm to handle the domain shifts at test time for medical images from different institutions without using extra training data. However, existing TTA solutions for segmentation tasks…

Computer Vision and Pattern Recognition · Computer Science 2024-10-03 Chuyan Zhang , Hao Zheng , Xin You , Yefeng Zheng , Yun Gu

Medical image segmentation plays a crucial role in clinical diagnosis and treatment planning, where accurate boundary delineation is essential for precise lesion localization, organ identification, and quantitative assessment. In recent…

Image and Video Processing · Electrical Eng. & Systems 2026-05-26 Peiting Tian , Xi Chen , Haixia Bi , Fan Li

In medical image segmentation, heterogeneous privacy policies across institutions often make joint training on pooled datasets infeasible, motivating continual image segmentation-learning from data streams without catastrophic forgetting.…

Computer Vision and Pattern Recognition · Computer Science 2025-11-24 Jiayi Wang , Wei Dai , Haoyu Wang , Sihan Yang , Haixia Bi , Jian Sun
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