Related papers: Quantum-optimal nonlinear microscopy with classica…
The success of non-linear optics relies largely on pulse-to-pulse consistency. In contrast, covariance based techniques used in photoionization electron spectroscopy and mass spectrometry have shown that wealth of information can be…
Sensors that are able to detect and track single unlabelled biomolecules are an important tool both to understand biomolecular dynamics and interactions at nanoscale, and for medical diagnostics operating at their ultimate detection limits.…
Quantum techniques can be used to enhance the signal-to-noise ratio in optical imaging. Leveraging the latest advances in single photon avalanche diode array cameras and multi-photon detection techniques, here we introduce a super-sensitive…
The ability to perform nanometer-scale optical imaging and spectroscopy is key to deciphering the low-energy effects in quantum materials, as well as vibrational fingerprints in planetary and extraterrestrial particles, catalytic…
Quantum noise places a fundamental limit on the per photon sensitivity attainable in optical measurements. This limit is of particular importance in biological measurements, where the optical power must be constrained to avoid damage to the…
In atomic and molecular phase measurements using laser-induced fluorescence detection, optical cycling can enhance the effective photon detection efficiency and hence improve sensitivity. We show that detecting many photons per atom or…
Raman scattering, an inelastic scattering mechanism, provides information about molecular excitation energies and can be used to identify chemical compounds. Albeit being a powerful analysis tool, especially for label-free biomedical…
Extracting information from weak optical signals is a critical challenge across a broad range of technologies. Conventional imaging techniques, constrained to integrating over detected signals and classical post-processing, are limited in…
Surface-Enhanced Raman Scattering (SERS) allows for detection and identification of molecular vibrational fingerprints in minute sample quantities. The SERS process can be also exploited for optical manipulation of molecular vibrations. We…
Quantum interferometry methods exploit quantum resources, such as photonic entanglement, to enhance phase estimation beyond classical limits. Nonlinear optics has served as a workhorse for the generation of entangled photon pairs, ensuring…
Chiral discrimination of enantiomeric biomolecules is vital in chemistry, biology, and medicine. Conventional methods, relying on circularly polarized light, face weak chiroptical signals and potential photodamage. Despite extensive efforts…
High-quality photonic Bell state measurements (BSMs) enable scalable universal quantum computing and long distance quantum communication. However, when implemented with linear optics, BSMs are fundamentally probabilistic, introducing…
We investigate the fundamental limit of biological quantum electron microscopy, which is designed to go beyond the shot noise limit. Inelastic scattering is expected to be the main obstacle in this setting, especially for thick specimens of…
Non-invasive light scattering methods provide data on biological macromolecules (i.e. proteins, nucleic acids, as well as assemblies and larger entities composed of them) that are complementary with those of size exclusion chromatography,…
Optical signals obtained by the material response to classical laser fields are given by nonlinear response functions which can be expressed by sums over various quantum pathways of matter. We show that some pathways can be selected by…
While scattered light conveys most of the information we perceive, scattering may also distort that information before it reaches our detectors. The problem is acute in many applications, such as in high-resolution microscopy of biological…
Raman spectroscopy's capability to provide meaningful composition predictions is heavily reliant on a pre-processing step to remove insignificant spectral variation. This is crucial in biofluid analysis. Widespread adoption of diagnostics…
Entanglement and quantum correlations are central to the physics of quantum materials, yet they have remained notoriously difficult to probe experimentally. Probing these phenomena in solids requires quantum optical probes that operate at…
Nonlinear spectroscopy is widely used for studying physical systems. Conventional nonlinear optical spectroscopy and magnetic resonance spectroscopy, which use classical probes such as electromagnetic waves, can only access certain types of…
Super-resolution imaging with advanced optical systems has been revolutionizing technical analysis in various fields from biological to physical sciences. However, many objects are hidden by strongly scattering media such as rough wall…