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Neural codes allow the brain to represent, process, and store information about the world. Combinatorial codes, comprised of binary patterns of neural activity, encode information via the collective behavior of populations of neurons. A…

Neurons and Cognition · Quantitative Biology 2016-12-22 Carina Curto , Elizabeth Gross , Jack Jeffries , Katherine Morrison , Mohamed Omar , Zvi Rosen , Anne Shiu , Nora Youngs

A combinatorial neural code $\mathscr C\subseteq 2^{[n]}$ is convex if it arises as the intersection pattern of convex open subsets of $\mathbb R^d$. We relate the emerging theory of convex neural codes to the established theory of oriented…

Combinatorics · Mathematics 2026-03-12 Alexander Kunin , Caitlin Lienkaemper , Zvi Rosen

Neural codes serve as a language for neurons in the brain. Convex codes, which arise from the pattern of intersections of convex sets in Euclidean space, are of particular relevance to neuroscience. Not every code is convex, however, and…

Combinatorics · Mathematics 2017-05-31 Joshua Cruz , Chad Giusti , Vladimir Itskov , Bill Kronholm

Neural codes, represented as collections of binary strings called codewords, are used to encode neural activity. A code is called convex if its codewords are represented as an arrangement of convex open sets in Euclidean space. Previous…

Combinatorics · Mathematics 2022-08-10 Katherine Johnston , Anne Shiu , Clare Spinner

To evaluate the nature of the neural code in the cerebral cortex, we have used a combination of theory and experiment to assess how information is represented in a realistic cortical population response. We have shown how a sensory stimulus…

Neurons and Cognition · Quantitative Biology 2008-03-28 L. C. Osborne , S. E. Palmer , S. G. Lisberger , W. Bialek

Neural codes, represented as collections of binary strings, encode neural activity and show relationships among stimuli. Certain neurons, called place cells, have been shown experimentally to fire in convex regions in space. A natural…

Neurons and Cognition · Quantitative Biology 2019-09-20 Sarah Ayman Goldrup , Kaitlyn Phillipson

The brain encodes spacial structure through a combinatorial code of neural activity. Experiments suggest such codes correspond to convex areas of the subject's environment. We present an intrinsic condition that implies a neural code may…

Combinatorics · Mathematics 2016-10-20 Robert Williams

Combinatorial neural codes are $0/1$ vectors that are used to model the co-firing patterns of a set of place cells in the brain. One wide-open problem in this area is to determine when a given code can be algorithmically drawn in the plane…

Combinatorics · Mathematics 2018-08-29 Robert Davis

A combinatorial code $\mathcal{C}$ is a collection of subsets of $[n]$, or equivalently a set of points in $\{0,1\}^n$. A morphism of codes is a map from one combinatorial code to another such that the coordinates of points in the image can…

Combinatorics · Mathematics 2026-03-12 Juliann Geraci , Alexander B. Kunin , Alexandra Seceleanu

This dissertation explores applications of discrete geometry in mathematical neuroscience. We begin with convex neural codes, which model the activity of hippocampal place cells and other neurons with convex receptive fields. In Chapter 4,…

Neurons and Cognition · Quantitative Biology 2022-09-19 Caitlin Lienkaemper

Neural codes are lists of subsets of neurons that fire together. Of particular interest are neurons called place cells, which fire when an animal is in specific, usually convex regions in space. A fundamental question, therefore, is to…

Combinatorics · Mathematics 2021-04-05 Brianna Gambacini , R. Amzi Jeffs , Sam Macdonald , Anne Shiu

Convex neural codes are subsets of the Boolean lattice that record the intersection patterns of convex sets in Euclidean space. Much work in recent years has focused on finding combinatorial criteria on codes that can be used to classify…

Combinatorics · Mathematics 2020-12-18 R. Amzi Jeffs , Caitlin Lienkaemper , Nora Youngs

A neural code $\mathcal{C}$ is a collection of binary vectors of a given length n that record the co-firing patterns of a set of neurons. Our focus is on neural codes arising from place cells, neurons that respond to geographic stimulus. In…

Neurons and Cognition · Quantitative Biology 2016-07-05 Elizabeth Gross , Nida Kazi Obatake , Nora Youngs

Neural codes are collections of binary strings motivated by patterns of neural activity. In this paper, we study algorithmic and enumerative aspects of convex neural codes in dimension 1 (i.e. on a line or a circle). We use the theory of…

Combinatorics · Mathematics 2017-02-23 Zvi Rosen , Yan X. Zhang

Determining how the brain stores information is one of the most pressing problems in neuroscience. In many instances, the collection of stimuli for a given neuron can be modeled by a convex set in $\mathbb{R}^d$. Combinatorial objects known…

Combinatorics · Mathematics 2019-05-29 R. Amzi Jeffs , Mohamed Omar , Natchanon Suaysom , Aleina Wachtel , Nora Youngs

Given an intersection pattern of arbitrary sets in Euclidean space, is there an arrangement of convex open sets in Euclidean space that exhibits the same intersections? This question is combinatorial and topological in nature, but is…

Combinatorics · Mathematics 2019-02-22 Aaron Chen , Florian Frick , Anne Shiu

Much work has been done to identify which binary codes can be represented by collections of open convex or closed convex sets. While not all binary codes can be realized by such sets, here we prove that every binary code can be realized by…

Combinatorics · Mathematics 2018-04-30 Megan K. Franke , Samuel Muthiah

We introduce combinatorial interpretability, a methodology for understanding neural computation by analyzing the combinatorial structures in the sign-based categorization of a network's weights and biases. We demonstrate its power through…

Machine Learning · Computer Science 2025-05-07 Micah Adler , Dan Alistarh , Nir Shavit

Convex neural codes are combinatorial structures describing the intersection pattern of a collection of convex sets. Inductively pierced codes are a particularly nice subclass of neural codes introduced in the information visualization…

Combinatorics · Mathematics 2019-07-01 Caitlin Lienkaemper

Neural codes are binary codes that are used for information processing and representation in the brain. In previous work, we have shown how an algebraic structure, called the {\it neural ring}, can be used to efficiently encode geometric…

Neurons and Cognition · Quantitative Biology 2019-02-14 Carina Curto , Nora Youngs
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