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Artificial Intelligence (AI) brings advancements to support pathologists in navigating high-resolution tumor images to search for pathology patterns of interest. However, existing AI-assisted tools have not realized this promised potential…

Artificial Intelligence (AI) has great potential to improve health outcomes by training systems on vast digitized clinical datasets. Computational Pathology, with its massive amounts of microscopy image data and impact on diagnostics and…

Image and Video Processing · Electrical Eng. & Systems 2024-05-24 Gabriele Campanella , Eugene Fluder , Jennifer Zeng , Chad Vanderbilt , Thomas J. Fuchs

Pathology images of histopathology can be acquired from camera-mounted microscopes or whole slide scanners. Utilizing similarity calculations to match patients based on these images holds significant potential in research and clinical…

Image and Video Processing · Electrical Eng. & Systems 2024-03-25 H. R. Tizhoosh , Liron Pantanowitz

Ensuring diagnostic performance of AI models before clinical use is key to the safe and successful adoption of these technologies. Studies reporting AI applied to digital pathology images for diagnostic purposes have rapidly increased in…

Accurate and timely cancer diagnosis from histopathological slides is vital for effective clinical decision-making. This paper introduces DepViT-CAD, a deployable AI system for multi-class cancer diagnosis in histopathology. At its core is…

Image and Video Processing · Electrical Eng. & Systems 2025-07-15 Ashkan Shakarami , Lorenzo Nicole , Rocco Cappellesso , Angelo Paolo Dei Tos , Stefano Ghidoni

Gastric endoscopic screening is an effective way to decide appropriate gastric cancer (GC) treatment at an early stage, reducing GC-associated mortality rate. Although artificial intelligence (AI) has brought a great promise to assist…

Image and Video Processing · Electrical Eng. & Systems 2023-08-16 Yujin Oh , Go Eun Bae , Kyung-Hee Kim , Min-Kyung Yeo , Jong Chul Ye

Digital pathology has emerged as a transformative approach to tissue analysis, offering unprecedented opportunities for objective, quantitative assessment of histopathological features. However, the complexity of implementing artificial…

Quantitative Methods · Quantitative Biology 2025-09-17 Noor Shaker , Mohamed AbouZleikha , Nuha Shaker

Background/Objectives: Age-related macular degeneration, glaucoma, diabetic retinopathy (DR), diabetic macular edema, and pathological myopia affect hundreds of millions of people worldwide. Early screening for these diseases is essential,…

Image and Video Processing · Electrical Eng. & Systems 2025-07-18 Ananya Raghu , Anisha Raghu , Alice S. Tang , Yannis M. Paulus , Tyson N. Kim , Tomiko T. Oskotsky

Diagnosing diseases through histopathology whole slide images (WSIs) is fundamental in modern pathology but is challenged by the gigapixel scale and complexity of WSIs. Trained histopathologists overcome this challenge by navigating the…

Computer Vision and Pattern Recognition · Computer Science 2025-02-14 Fatemeh Ghezloo , Mehmet Saygin Seyfioglu , Rustin Soraki , Wisdom O. Ikezogwo , Beibin Li , Tejoram Vivekanandan , Joann G. Elmore , Ranjay Krishna , Linda Shapiro

The histological assessment of human tissue has emerged as the key challenge for detection and treatment of cancer. A plethora of different data sources ranging from tissue microarray data to gene expression, proteomics or metabolomics data…

Computer Vision and Pattern Recognition · Computer Science 2016-01-05 Thomas J. Fuchs , Joachim M. Buhmann

The emergence of digital pathology has opened new horizons for histopathology and cytology. Artificial-intelligence algorithms are able to operate on digitized slides to assist pathologists with diagnostic tasks. Whereas machine learning…

Noninvasive optical imaging modalities can probe patient's tissue in 3D and over time generate gigabytes of clinically relevant data per sample. There is a need for AI models to analyze this data and assist clinical workflow. The lack of…

Recent advances in agentic artificial intelligence, i.e. systems capable of autonomous perception, reasoning, and tool use, offer new opportunities for digital pathology. In this pilot study, we evaluate whether two agentic multimodal AI…

Human-Computer Interaction · Computer Science 2026-01-21 Marc Aubreville , Taryn A. Donovan , Christof A. Bertram

Histopathological image analysis is the gold standard to diagnose cancer. Carcinoma is a subtype of cancer that constitutes more than 80% of all cancer cases. Squamous cell carcinoma and adenocarcinoma are two major subtypes of carcinoma,…

Image and Video Processing · Electrical Eng. & Systems 2022-01-20 Swathi Prabhua , Keerthana Prasada , Antonio Robels-Kelly , Xuequan Lu

Histopathological image analysis is an essential process for the discovery of diseases such as cancer. However, it is challenging to train CNN on whole slide images (WSIs) of gigapixel resolution considering the available memory capacity.…

Image and Video Processing · Electrical Eng. & Systems 2019-10-11 Shusuke Takahama , Yusuke Kurose , Yusuke Mukuta , Hiroyuki Abe , Masashi Fukayama , Akihiko Yoshizawa , Masanobu Kitagawa , Tatsuya Harada

Digital pathology has advanced significantly over the last decade, with Whole Slide Images (WSIs) encompassing vast amounts of data essential for accurate disease diagnosis. High-resolution WSIs are essential for precise diagnosis but…

Image and Video Processing · Electrical Eng. & Systems 2024-08-28 Xuan Xu , Saarthak Kapse , Prateek Prasanna

The field of computational pathology has witnessed remarkable progress in the development of both task-specific predictive models and task-agnostic self-supervised vision encoders. However, despite the explosive growth of generative…

Computer Vision and Pattern Recognition · Computer Science 2023-12-14 Ming Y. Lu , Bowen Chen , Drew F. K. Williamson , Richard J. Chen , Kenji Ikamura , Georg Gerber , Ivy Liang , Long Phi Le , Tong Ding , Anil V Parwani , Faisal Mahmood

In the cancer diagnosis pipeline, digital pathology plays an instrumental role in the identification, staging, and grading of malignant areas on biopsy tissue specimens. High resolution histology images are subject to high variance in…

Image and Video Processing · Electrical Eng. & Systems 2023-08-17 Vasileios Magoulianitis , Catherine A. Alexander , C. -C. Jay Kuo

For doctors to truly trust artificial intelligence, it can't be a black box. They need to understand its reasoning, almost as if they were consulting a colleague. We created HistoLens1 to be that transparent, collaborative partner. It…

Artificial Intelligence · Computer Science 2025-10-29 Sandeep Vissapragada , Vikrant Sahu , Gagan Raj Gupta , Vandita Singh

The expanding adoption of digital pathology has enabled the curation of large repositories of histology whole slide images (WSIs), which contain a wealth of information. Similar pathology image search offers the opportunity to comb through…

Computer Vision and Pattern Recognition · Computer Science 2021-07-30 Chengkuan Chen , Ming Y. Lu , Drew F. K. Williamson , Tiffany Y. Chen , Andrew J. Schaumberg , Faisal Mahmood