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The ability to effectively control brain dynamics holds great promise for the enhancement of cognitive function in humans, and the betterment of their quality of life. Yet, successfully controlling dynamics in neural systems is challenging,…

Quantitative Methods · Quantitative Biology 2018-08-29 Evelyn Tang , Danielle S. Bassett

Computational psychiatry is a field aimed at developing formal models of information processing in the human brain, and how alterations in this processing can lead to clinical phenomena. Despite significant progress in the development of…

Neurons and Cognition · Quantitative Biology 2023-01-12 David Benrimoh , Victoria Fisher , Catalina Mourgues , Andrew D. Sheldon , Ryan Smith , Albert R. Powers

This project investigates whether functional specialization or modularity can support the development of multiple behaviors. In principle, modular solutions of this type can facilitate the development of multiple behaviors since each module…

Robotics · Computer Science 2020-06-12 Victor Massagué Respall

A significant and rising proportion of the global population suffer from non-communicable diseases, such as neurological disorders. Neurorehabilitation aims to restore function and independence of neurological patients through providing…

Continual learning can enable neural networks to evolve by learning new tasks sequentially in task-changing scenarios. However, two general and related challenges should be overcome in further research before we apply this technique to…

Machine Learning · Computer Science 2022-02-15 Yujiang He , Zhixin Huang , Bernhard Sick

Sleep is particularly important to the health of infants, children, and adolescents, and sleep scoring is the first step to accurate diagnosis and treatment of potentially life-threatening conditions. But pediatric sleep is severely…

Signal Processing · Electrical Eng. & Systems 2022-10-27 Harlin Lee , Aaqib Saeed

Neurostimulation is a promising therapy for abating epileptic seizures. However, it is extremely difficult to identify optimal stimulation patterns experimentally. In this study human recordings are used to develop a functional 24 neuron…

Objective - This work introduces Dareplane, a modular and broad technology-agnostic open source software platform for brain-computer interface research with an application focus on adaptive deep brain stimulation (aDBS). One difficulty for…

Other Quantitative Biology · Quantitative Biology 2025-02-19 Matthias Dold , Joana Pereira , Bastian Sajonz , Volker A. Coenen , Jordy Thielen , Marcus L. F. Janssen , Michael Tangermann

Intelligent systems must maintain and manipulate task-relevant information online to adapt to dynamic environments and changing goals. This capacity, known as working memory, is fundamental to human reasoning and intelligence. Despite…

Machine Learning · Computer Science 2026-04-14 Hua-Dong Xiong , Li Ji-An , Jiaqi Huang , Robert C. Wilson , Kwonjoon Lee , Xue-Xin Wei

While the shift toward unified foundation models has revolutionized many deep learning domains, sleep medicine remains largely restricted to task-specific models that focus on localized micro-structure features. These approaches often…

Artificial Intelligence · Computer Science 2026-02-10 Keondo Park , Younghoon Na , Yourim Choi , Hyunwoo Ryu , Hyun-Woo Shin , Hyung-Sin Kim

Identifying bio-signals based-sleep stages requires time-consuming and tedious labor of skilled clinicians. Deep learning approaches have been introduced in order to challenge the automatic sleep stage classification conundrum. However, the…

Closed-loop neuromodulation systems aim to treat a variety of neurological conditions by dynamically delivering and adjusting therapeutic electrical stimulation in response to a patient's neural state, recorded in real-time. Existing…

Sleep stage classification is a widely discussed topic, due to its importance in the diagnosis of sleep disorders, e.g. insomnia. Analysis of the brain activity during sleep is necessary to gain further insight into the processing that…

Signal Processing · Electrical Eng. & Systems 2024-10-08 Alexander Edthofer , Iris Feldhammer , Thomas Fenzl , Andreas Körner , Matthias Kreuzer

Ensuring robust safety alignment while preserving utility is critical for the reliable deployment of Large Language Models (LLMs). However, current techniques fundamentally suffer from intertwined deficiencies: insufficient robustness…

Machine Learning · Computer Science 2025-08-14 Birong Pan , Mayi Xu , Qiankun Pi , Jianhao Chen , Yuanyuan Zhu , Ming Zhong , Tieyun Qian

Study Objectives: Fetal sleep is a vital yet underexplored aspect of prenatal neurodevelopment. Its cyclic organization reflects the maturation of central neural circuits, and disturbances in these patterns may offer some of the earliest…

Neurons and Cognition · Quantitative Biology 2026-01-19 Weitao Tang , Johann Vargas-Calixto , Nasim Katebi , Robert Galinsky , Gari D. Clifford , Faezeh Marzbanrad

The human brain is a complex network that supports mental function. The nascent field of network neuroscience applies tools from mathematics to neuroimaging data in the hopes of shedding light on cognitive function. A critical question…

Neurons and Cognition · Quantitative Biology 2017-04-26 John D. Medaglia , Perry Zurn , Walter Sinnott-Armstrong , Danielle S. Bassett

Linear and nonlinear resonant states can be restrictive: they exist at particular discrete states in frequency and/or elasticity, under particular (e.g., simple-harmonic) waveforms. In forced oscillators, this restrictiveness is an obstacle…

Systems and Control · Electrical Eng. & Systems 2022-11-16 Arion Pons , Tsevi Beatus

Multimodal learning has significantly enhanced machine learning performance but still faces numerous challenges and limitations. Imbalanced multimodal learning is one of the problems extensively studied in recent works and is typically…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Shu Shen , C. L. Philip Chen , Tong Zhang

Modularity is a general principle present in many fields. It offers attractive advantages, including, among others, ease of conceptualization, interpretability, scalability, module combinability, and module reusability. The deep learning…

Machine Learning · Computer Science 2023-10-03 Haozhe Sun , Isabelle Guyon

To tackle complex tasks in real-world scenarios, more researchers are focusing on Omni-MLLMs, which aim to achieve omni-modal understanding and generation. Beyond the constraints of any specific non-linguistic modality, Omni-MLLMs map…

Artificial Intelligence · Computer Science 2025-03-05 Shixin Jiang , Jiafeng Liang , Jiyuan Wang , Xuan Dong , Heng Chang , Weijiang Yu , Jinhua Du , Ming Liu , Bing Qin
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