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Recent developments in large language models (LLMs) have unlocked new opportunities for healthcare, from information synthesis to clinical decision support. These new LLMs are not just capable of modeling language, but can also act as…

Human-Computer Interaction · Computer Science 2023-09-21 Nikita Mehandru , Brenda Y. Miao , Eduardo Rodriguez Almaraz , Madhumita Sushil , Atul J. Butte , Ahmed Alaa

Multi-agent systems coordinate LLM-based agents to perform tasks on users' behalf. In real-world applications, multi-agent systems will inevitably interact with untrusted inputs, such as malicious Web content, files, email attachments, and…

Cryptography and Security · Computer Science 2025-09-16 Harold Triedman , Rishi Jha , Vitaly Shmatikov

Advances in AI offer the prospect of manipulating beliefs and behaviors on a population-wide level. Large language models and autonomous agents now let influence campaigns reach unprecedented scale and precision. Generative tools can expand…

As Large Language Models (LLMs) get integrated into diverse workflows, they are increasingly being regarded as "collaborators" with humans, and required to work in coordination with other AI systems. If such AI collaborators are to reliably…

Computation and Language · Computer Science 2026-01-23 Abhijnan Nath , Carine Graff , Nikhil Krishnaswamy

This paper presents an innovative large language model (LLM) agent framework for enhancing diagnostic accuracy in simulated clinical environments using the AgentClinic benchmark. The proposed automatic correction enables doctor agents to…

Artificial Intelligence · Computer Science 2024-10-15 Abhishek Dutta , Yen-Che Hsiao

Large language models (LLMs) are increasingly deployed in collaborative tasks involving multiple agents, forming an "AI agent society: where agents interact and influence one another. Whether such groups can spontaneously coordinate on…

Physics and Society · Physics 2025-04-16 Giordano De Marzo , Claudio Castellano , David Garcia

Large Language Model (LLM) safeguards, which implement request refusals, have become a widely adopted mitigation strategy against misuse. At the intersection of adversarial machine learning and AI safety, safeguard red teaming has…

Cryptography and Security · Computer Science 2025-06-10 Zifan Wang , Christina Q. Knight , Jeremy Kritz , Willow E. Primack , Julian Michael

As large language models (LLMs) are increasingly deployed as interactive agents, open-ended human-AI interactions can involve deceptive behaviors with serious real-world consequences, yet existing evaluations remain largely…

Artificial Intelligence · Computer Science 2026-02-09 Yichen Wu , Qianqian Gao , Xudong Pan , Geng Hong , Min Yang

This study investigates whether large language models (LLMs) can function as intelligent collaborators to bridge expertise gaps in cybersecurity decision-making. We examine two representative tasks-phishing email detection and intrusion…

Cryptography and Security · Computer Science 2025-05-07 Shahroz Tariq , Ronal Singh , Mohan Baruwal Chhetri , Surya Nepal , Cecile Paris

The integration of Large Language Models (LLMs) into healthcare demands a safety paradigm rooted in \textit{primum non nocere}. However, current alignment techniques rely on generic definitions of harm that fail to capture context-dependent…

Computers and Society · Computer Science 2025-12-01 Andrew Maranhão Ventura D'addario

Large Language Models (LLMs) are transforming human decision-making by acting as cognitive collaborators. Yet, this promise comes with a paradox: while LLMs can improve accuracy, they may also erode independent reasoning, promote…

Cryptography and Security · Computer Science 2025-09-09 Irdin Pekaric , Philipp Zech , Tom Mattson

This study investigates uncertainty quantification in large language models (LLMs) for medical applications, emphasizing both technical innovations and philosophical implications. As LLMs become integral to clinical decision-making,…

Artificial Intelligence · Computer Science 2025-04-08 Zahra Atf , Seyed Amir Ahmad Safavi-Naini , Peter R. Lewis , Aref Mahjoubfar , Nariman Naderi , Thomas R. Savage , Ali Soroush

Complex medical decision-making involves cooperative workflows operated by different clinicians. Designing AI multi-agent systems can expedite and augment human-level clinical decision-making. Existing multi-agent researches primarily focus…

Artificial Intelligence · Computer Science 2025-10-14 Kaitao Chen , Mianxin Liu , Daoming Zong , Chaoyue Ding , Shaohao Rui , Yankai Jiang , Mu Zhou , Xiaosong Wang

Although large language models (LLMs) have been assessed for general medical knowledge using licensing exams, their ability to support clinical decision-making, such as selecting medical calculators, remains uncertain. We assessed nine…

Computation and Language · Computer Science 2025-03-25 Nicholas Wan , Qiao Jin , Joey Chan , Guangzhi Xiong , Serina Applebaum , Aidan Gilson , Reid McMurry , R. Andrew Taylor , Aidong Zhang , Qingyu Chen , Zhiyong Lu

Multi-agent large language model (LLM) architectures increasingly rely on response-level aggregation, such as Majority Voting (MAJ), to raise reasoning ceilings. However, in open environments, agents are highly susceptible to stealthy…

Computation and Language · Computer Science 2026-04-21 Jiayuan Liu , Shiyi Du , Weihua Du , Mingyu Guo , Vincent Conitzer

Autonomous browsing agents powered by large language models (LLMs) are increasingly used to automate web-based tasks. However, their reliance on dynamic content, tool execution, and user-provided data exposes them to a broad attack surface.…

Cryptography and Security · Computer Science 2025-05-20 Mykyta Mudryi , Markiyan Chaklosh , Grzegorz Wójcik

Large language models (LLMs) deployed as agents introduce significant safety risks in clinical settings due to their potential for error and single points of failure. We introduce Tiered Agentic Oversight (TAO), a hierarchical multi-agent…

Credible safety plans for advanced AI development require methods to verify agent behavior and detect potential control deficiencies early. A fundamental aspect is ensuring agents adhere to safety-critical principles, especially when these…

Machine Learning · Computer Science 2025-07-11 Ram Potham

As AI systems advance in capabilities, measuring their safety and alignment to human values is becoming paramount. A fast-growing field of AI research is devoted to developing such assessments. However, most current advances therein may be…

Computers and Society · Computer Science 2026-03-17 Max Hellrigel-Holderbaum , Edward James Young

Large Language Models demonstrate remarkable capabilities yet remain fundamentally probabilistic, presenting critical reliability challenges for enterprise deployment. We introduce the Six Sigma Agent, a novel architecture that achieves…

Artificial Intelligence · Computer Science 2026-02-02 Khush Patel , Siva Surendira , Jithin George , Shreyas Kapale