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Related papers: COPE: Chain-Of-Thought Prediction Engine for Open-…

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Accurate prediction of clinical outcomes using Electronic Health Records (EHRs) is critical for early intervention, efficient resource allocation, and improved patient care. EHRs contain multimodal data, including both structured data and…

Machine Learning · Computer Science 2025-08-29 Rituparna Datta , Jiaming Cui , Zihan Guan , Vishal G. Reddy , Joshua C. Eby , Gregory Madden , Rupesh Silwal , Anil Vullikanti

Chain-of-Thought (CoT) prompting improves LLM reasoning but can increase privacy risk by resurfacing personally identifiable information (PII) from the prompt into reasoning traces and outputs, even under policies that instruct the model…

Computation and Language · Computer Science 2026-03-09 Patrick Ahrend , Tobias Eder , Xiyang Yang , Zhiyi Pan , Georg Groh

While ischemic stroke is a leading cause of death worldwide, there has been little success translating putative cerebroprotectants from rodent preclinical trials to human patients. We investigated computational image-based assessment tools…

Fine-tuning Large Language Models (LLMs) with reinforcement learning to produce an explicit Chain-of-Thought (CoT) before answering produces models that consistently raise overall performance on code, math, and general-knowledge benchmarks.…

Computation and Language · Computer Science 2025-08-25 Arne Vanhoyweghen , Brecht Verbeken , Andres Algaba , Vincent Ginis

This paper introduces a simple efficient learning algorithms for general sequential decision making. The algorithm combines Optimism for exploration with Maximum Likelihood Estimation for model estimation, which is thus named OMLE. We prove…

Machine Learning · Computer Science 2022-11-24 Qinghua Liu , Praneeth Netrapalli , Csaba Szepesvári , Chi Jin

Treatment of acute ischemic strokes (AIS) is largely contingent upon the time since stroke onset (TSS). However, TSS may not be readily available in up to 25% of patients with unwitnessed AIS. Current clinical guidelines for patients with…

Image and Video Processing · Electrical Eng. & Systems 2021-05-03 Haoyue Zhang , Jennifer S Polson , Kambiz Nael , Noriko Salamon , Bryan Yoo , Suzie El-Saden , Fabien Scalzo , William Speier , Corey W Arnold

Clinical notes are often stored in unstructured or semi-structured formats after extraction from electronic medical record (EMR) systems, which complicates their use for secondary analysis and downstream clinical applications. Reliable…

Computation and Language · Computer Science 2025-12-30 Risha Surana , Adrian Law , Sunwoo Kim , Rishab Sridhar , Angxiao Han , Peiyu Hong

Chain-of-thought (CoT) reasoning is useful for monitoring language models only when the reasoning trace faithfully reflects the computation that produces the final answer. However, models can rely on prompt-to-answer shortcuts that bypass…

Machine Learning · Computer Science 2026-05-26 Jinghan Jia , Joe Benton , Eric Easley

Modeling clinical time-series data is hampered by the challenge of capturing latent, time-varying dependencies among features. State-of-the-art approaches often rely on black-box mechanisms or simple aggregation, failing to explicitly model…

Machine Learning · Computer Science 2026-01-21 Yubo Li , Rema Padman

Writing clinical notes and documenting medical exams is a critical task for healthcare professionals, serving as a vital component of patient care documentation. However, manually writing these notes is time-consuming and can impact the…

Computation and Language · Computer Science 2025-06-17 Yizhan Li , Sifan Wu , Christopher Smith , Thomas Lo , Bang Liu

Chain-of-Thought (CoT) prompting can dramatically improve the multi-step reasoning abilities of large language models (LLMs). CoT explicitly encourages the LLM to generate intermediate rationales for solving a problem, by providing a series…

Computation and Language · Computer Science 2023-06-02 Boshi Wang , Sewon Min , Xiang Deng , Jiaming Shen , You Wu , Luke Zettlemoyer , Huan Sun

Post-stroke patient rehabilitation requires precise, personalized treatment plans. Natural Language Processing (NLP) offers potential to extract valuable exercise information from clinical notes, aiding in the development of more effective…

Computation and Language · Computer Science 2024-03-18 Sonish Sivarajkumar , Fengyi Gao , Parker E. Denny , Bayan M. Aldhahwani , Shyam Visweswaran , Allyn Bove , Yanshan Wang

Chain-of-thought (CoT) prompting has demonstrated the capacity of large language models to perform complex reasoning through intermediate steps. While effective, current CoT methods face challenges: Zero-shot-CoT can lead to reasoning…

Computation and Language · Computer Science 2025-02-12 Ziqi Jin , Wei Lu

Objective: Machine learning (ML) predictive models are often developed without considering downstream value trade-offs and clinical interpretability. This paper introduces a cost-aware prediction (CAP) framework that combines cost-benefit…

Machine Learning · Computer Science 2025-11-20 Yinan Yu , Falk Dippel , Christina E. Lundberg , Martin Lindgren , Annika Rosengren , Martin Adiels , Helen Sjöland

Many existing models for clinical trial outcome prediction are optimized using task-specific loss functions on trial phase-specific data. While this scheme may boost prediction for common diseases and drugs, it can hinder learning of…

Machine Learning · Computer Science 2025-05-27 Yiqing Zhang , Xiaozhong Liu , Fabricio Murai

Objective: This study introduces ChatSchema, an effective method for extracting and structuring information from unstructured data in medical paper reports using a combination of Large Multimodal Models (LMMs) and Optical Character…

Computation and Language · Computer Science 2024-07-29 Fei Wang , Yuewen Zheng , Qin Li , Jingyi Wu , Pengfei Li , Luxia Zhang

Reasoning capability is pivotal for Large Language Models (LLMs) to solve complex tasks, yet achieving reliable and scalable reasoning remains challenging. While Chain-of-Thought (CoT) prompting has become a mainstream approach, existing…

Computation and Language · Computer Science 2025-10-07 Honglin Lin , Qizhi Pei , Xin Gao , Zhuoshi Pan , Yu Li , Juntao Li , Conghui He , Lijun Wu

This report examines the effectiveness of Chain-of-Thought (CoT) prompting in improving the multi-step reasoning abilities of large language models (LLMs). Inspired by previous studies \cite{Min2022RethinkingWork}, we analyze the impact of…

Computation and Language · Computer Science 2023-09-29 Aayush Mishra , Karan Thakkar

Effective clinical history taking is a foundational yet underexplored component of clinical reasoning. While large language models (LLMs) have shown promise on static benchmarks, they often fall short in dynamic, multi-turn diagnostic…

Computation and Language · Computer Science 2026-01-30 Yang Zhou , Zhenting Sheng , Mingrui Tan , Yuting Song , Jun Zhou , Yu Heng Kwan , Lian Leng Low , Yang Bai , Yong Liu

Large Language Models (LLMs) demonstrate strong performance on mathematical problems when prompted with Chain-of-Thought (CoT), yet it remains unclear whether this success stems from search, rote procedures, or rule-consistent reasoning. To…

Artificial Intelligence · Computer Science 2026-03-03 Yuanhe Zhang , Ilja Kuzborskij , Jason D. Lee , Chenlei Leng , Fanghui Liu