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Real-world problems are often dependent on multiple data modalities, making multimodal fusion essential for leveraging diverse information sources. In high-stakes domains, such as in healthcare, understanding how each modality contributes…

Neural and Evolutionary Computing · Computer Science 2025-05-19 Mafalda Malafaia , Thalea Schlender , Tanja Alderliesten , Peter A. N. Bosman

This paper introduces the front-propagation algorithm, a novel eXplainable AI (XAI) technique designed to elucidate the decision-making logic of deep neural networks. Unlike other popular explainability algorithms such as Integrated…

Artificial Intelligence · Computer Science 2024-05-28 Javier Viaña

Deep neural networks (DNNs) are being increasingly used to make predictions from functional magnetic resonance imaging (fMRI) data. However, they are widely seen as uninterpretable "black boxes", as it can be difficult to discover what…

Machine Learning · Computer Science 2020-12-18 Patrick McClure , Dustin Moraczewski , Ka Chun Lam , Adam Thomas , Francisco Pereira

In an ever expanding set of research and application areas, deep neural networks (DNNs) set the bar for algorithm performance. However, depending upon additional constraints such as processing power and execution time limits, or…

Machine Learning · Computer Science 2021-06-22 Nathan Dahlin , Krishna Chaitanya Kalagarla , Nikhil Naik , Rahul Jain , Pierluigi Nuzzo

Explainable AI (xAI) interventions aim to improve interpretability for complex black-box models, not only to improve user trust but also as a means to extract scientific insights from high-performing predictive systems. In molecular…

Machine Learning · Computer Science 2025-04-04 Jonas Teufel , Annika Leinweber , Pascal Friederich

In recent years, artificial intelligence (AI) systems have come to the forefront. These systems, mostly based on Deep learning (DL), achieve excellent results in areas such as image processing, natural language processing, or speech…

Computer Vision and Pattern Recognition · Computer Science 2023-04-18 Frantisek Sefcik , Wanda Benesova

Deep learning models are used in critical applications, in which mistakes can have serious consequences. Therefore, it is crucial to understand how and why models generate predictions. This understanding provides useful information to check…

The rapid evolution of machine learning (ML) has led to the widespread adoption of complex "black box" models, such as deep neural networks and ensemble methods. These models exhibit exceptional predictive performance, making them…

Machine Learning · Computer Science 2025-03-28 Moncef Garouani , Josiane Mothe , Ayah Barhrhouj , Julien Aligon

As AI-based medical devices are becoming more common in imaging fields like radiology and histology, interpretability of the underlying predictive models is crucial to expand their use in clinical practice. Existing heatmap-based…

Image and Video Processing · Electrical Eng. & Systems 2021-01-20 Kathryn Schutte , Olivier Moindrot , Paul Hérent , Jean-Baptiste Schiratti , Simon Jégou

The explainability of black-box machine learning algorithms, commonly known as Explainable Artificial Intelligence (XAI), has become crucial for financial and other regulated industrial applications due to regulatory requirements and the…

Machine Learning · Computer Science 2024-08-14 Gregory Yampolsky , Dhruv Desai , Mingshu Li , Stefano Pasquali , Dhagash Mehta

In this study, we present an interpretable deep learning framework for the early detection of breast cancer using quantitative features extracted from digitized fine needle aspirate (FNA) images of breast masses. Our deep neural network,…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Bishal Chhetri , B. V. Rathish Kumar

While deep learning models have demonstrated remarkable success in numerous domains, their black-box nature remains a significant limitation, especially in critical fields such as medical image analysis and inference. Existing…

Machine Learning · Computer Science 2025-05-13 David Zucker

The prediction of protein interactions (CPIs) is crucial for the in-silico screening step in drug discovery. Recently, many end-to-end representation learning methods using deep neural networks have achieved significantly better performance…

Quantitative Methods · Quantitative Biology 2020-11-30 Jingtao Wang , Xi Li , Hua Zhang

For many applications, utilizing DNNs (Deep Neural Networks) requires their implementation on a target architecture in an optimized manner concerning energy consumption, memory requirement, throughput, etc. DNN compression is used to reduce…

Computer Vision and Pattern Recognition · Computer Science 2020-08-21 Muhammad Sabih , Frank Hannig , Juergen Teich

The importance of explainability in AI has become a pressing concern, for which several explainable AI (XAI) approaches have been recently proposed. However, most of the available XAI techniques are post-hoc methods, which however may be…

Machine Learning · Computer Science 2022-04-15 Leonardo Lucio Custode , Giovanni Iacca

With the long term accumulation of high quality educational data, artificial intelligence has shown excellent performance in knowledge tracing. However, due to the lack of interpretability and transparency of some algorithms, this approach…

Computation and Language · Computer Science 2024-03-13 Yanhong Bai , Jiabao Zhao , Tingjiang Wei , Qing Cai , Liang He

Identification of drug-target interactions (DTIs) plays a key role in drug discovery. The high cost and labor-intensive nature of in vitro and in vivo experiments have highlighted the importance of in silico-based DTI prediction approaches.…

Quantitative Methods · Quantitative Biology 2019-09-11 Ingoo Lee , Jongsoo Keum , Hojung Nam

The characterization of drug-protein interactions is crucial in the high-throughput screening for drug discovery. The deep learning-based approaches have attracted attention because they can predict drug-protein interactions without…

Machine Learning · Computer Science 2020-12-22 QHwan Kim , Joon-Hyuk Ko , Sunghoon Kim , Nojun Park , Wonho Jhe

Explaining machine learning (ML) models using eXplainable AI (XAI) techniques has become essential to make them more transparent and trustworthy. This is especially important in high-stakes domains like healthcare, where understanding model…

Machine Learning · Computer Science 2025-12-04 Felix Tempel , Daniel Groos , Espen Alexander F. Ihlen , Lars Adde , Inga Strümke

Improving the interpretability of geospatial artificial intelligence (GeoAI) models has become critically important to open the "black box" of complex AI models, such as deep learning. This paper compares popular saliency map generation…

Computer Vision and Pattern Recognition · Computer Science 2023-03-20 Chia-Yu Hsu , Wenwen Li