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Related papers: RadDiff: Retrieval-Augmented Denoising Diffusion f…

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Aside from offering state-of-the-art performance in medical image generation, denoising diffusion probabilistic models (DPM) can also serve as a representation learner to capture semantic information and potentially be used as an image…

Image and Video Processing · Electrical Eng. & Systems 2024-07-09 Chun-Mei Feng

This paper presents PolyDiffuse, a novel structured reconstruction algorithm that transforms visual sensor data into polygonal shapes with Diffusion Models (DM), an emerging machinery amid exploding generative AI, while formulating…

Computer Vision and Pattern Recognition · Computer Science 2023-12-27 Jiacheng Chen , Ruizhi Deng , Yasutaka Furukawa

Diffusion models have demonstrated their utility as learned priors for solving various inverse problems. However, most existing approaches are limited to linear inverse problems. This paper exploits the efficient and unsupervised posterior…

Image and Video Processing · Electrical Eng. & Systems 2025-01-07 Mehmet Onurcan Kaya , Figen S. Oktem

Structure-based drug design (SBDD), which aims to generate molecules that can bind tightly to the target protein, is an essential problem in drug discovery, and previous approaches have achieved initial success. However, most existing…

Machine Learning · Computer Science 2024-04-04 Xinze Li , Penglei Wang , Tianfan Fu , Wenhao Gao , Chengtao Li , Leilei Shi , Junhong Liu

Code generation is increasingly critical for real-world applications. Still, diffusion-based large language models continue to struggle with this demand. Unlike free-form text, code requires syntactic precision; even minor structural…

Computation and Language · Computer Science 2026-01-07 Yiming Zeng , Jinghan Cao , Zexin Li , Yiming Chen , Tao Ren , Zhuochun Li , Dawei Xiang , Xidong Wu , Shangqian Gao , Tingting Yu

Inverse protein folding is a fundamental task in computational protein design, which aims to design protein sequences that fold into the desired backbone structures. While the development of machine learning algorithms for this task has…

Machine Learning · Computer Science 2024-11-05 Yiheng Zhu , Jialu Wu , Qiuyi Li , Jiahuan Yan , Mingze Yin , Wei Wu , Mingyang Li , Jieping Ye , Zheng Wang , Jian Wu

Self-supervised pre-training methods on proteins have recently gained attention, with most approaches focusing on either protein sequences or structures, neglecting the exploration of their joint distribution, which is crucial for a…

Machine Learning · Computer Science 2023-07-11 Zuobai Zhang , Minghao Xu , Aurélie Lozano , Vijil Chenthamarakshan , Payel Das , Jian Tang

Inverse folding models play an important role in structure-based design by predicting amino acid sequences that fold into desired reference structures. Models like ProteinMPNN, a message-passing encoder-decoder model, are trained to…

Machine Learning · Computer Science 2026-05-12 Ryan Park , Darren J. Hsu , C. Brian Roland , Maria Korshunova , Chen Tessler , Shie Mannor , Olivia Viessmann , Bruno Trentini

Current methods based on deep learning for self-supervised low-dose CT (LDCT) reconstruction, while reducing the dependence on paired data, face the problem of significantly decreased generalization when training with single-dose data and…

Computer Vision and Pattern Recognition · Computer Science 2026-01-22 Guoquan Wei , Liu Shi , Zekun Zhou , Mohan Li , Cunfeng Wei , Wenzhe Shan , Qiegen Liu

Diffusion models have emerged as powerful generative frameworks by progressively adding noise to data through a forward process and then reversing this process to generate realistic samples. While these models have achieved strong…

Machine Learning · Computer Science 2025-03-04 Xingzhuo Guo , Yu Zhang , Baixu Chen , Haoran Xu , Jianmin Wang , Mingsheng Long

As one of the most successful generative models, diffusion models have demonstrated remarkable efficacy in synthesizing high-quality images. These models learn the underlying high-dimensional data distribution in an unsupervised manner.…

Computer Vision and Pattern Recognition · Computer Science 2024-12-12 Min Hou , Yueying Wu , Chang Xu , Yu-Hao Huang , Chenxi Bai , Le Wu , Jiang Bian

Distillation addresses the slow sampling problem in diffusion models by creating models with smaller size or fewer steps that approximate the behavior of high-step teachers. In this work, we propose a reinforcement learning based…

Machine Learning · Computer Science 2025-12-30 Amirhossein Tighkhorshid , Zahra Dehghanian , Gholamali Aminian , Chengchun Shi , Hamid R. Rabiee

Denoising diffusion models are a powerful type of generative models used to capture complex distributions of real-world signals. However, their applicability is limited to scenarios where training samples are readily available, which is not…

Computer Vision and Pattern Recognition · Computer Science 2023-11-20 Ayush Tewari , Tianwei Yin , George Cazenavette , Semon Rezchikov , Joshua B. Tenenbaum , Frédo Durand , William T. Freeman , Vincent Sitzmann

Recovering noise-covered details from low-light images is challenging, and the results given by previous methods leave room for improvement. Recent diffusion models show realistic and detailed image generation through a sequence of…

Computer Vision and Pattern Recognition · Computer Science 2023-05-18 Dewei Zhou , Zongxin Yang , Yi Yang

Diffusion and flow-based models have enabled significant progress in generation tasks across various modalities and have recently found applications in predictive learning. However, unlike typical generation tasks that encourage sample…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Yu Zhang , Xingzhuo Guo , Haoran Xu , Jialong Wu , Mingsheng Long

Proteins are fundamental to biology, executing diverse functions through complex physicochemical interactions, and they hold transformative potential across medicine, materials science, and environmental applications. Protein Language…

Biomolecules · Quantitative Biology 2025-06-11 Logan Hallee , Nikolaos Rafailidis , David B. Bichara , Jason P. Gleghorn

Most large language models are autoregressive: they generate tokens one at a time. Discrete diffusion language models can generate multiple tokens in parallel, but sampling from them requires a denoising order: a strategy for deciding which…

Artificial Intelligence · Computer Science 2026-03-27 Daniel Israel , Tian Jin , Ellie Cheng , Guy Van den Broeck , Aditya Grover , Suvinay Subramanian , Michael Carbin

Removing degradation from document images not only improves their visual quality and readability, but also enhances the performance of numerous automated document analysis and recognition tasks. However, existing regression-based methods…

Computer Vision and Pattern Recognition · Computer Science 2023-08-10 Zongyuan Yang , Baolin Liu , Yongping Xiong , Lan Yi , Guibin Wu , Xiaojun Tang , Ziqi Liu , Junjie Zhou , Xing Zhang

Recovering high-dimensional statistical structure from limited measurements is a fundamental challenge in hyperspectral imaging, where capturing full-resolution data is often infeasible due to sensor, bandwidth, or acquisition constraints.…

Image and Video Processing · Electrical Eng. & Systems 2025-08-01 Jonathan Monsalve , Kumar Vijay Mishra

Score-based diffusion models achieve state-of-the-art performance for inverse problems, but their practical deployment is hindered by long inference times and cumbersome hyperparameter tuning. While pretrained diffusion models can be reused…

Computer Vision and Pattern Recognition · Computer Science 2026-05-13 Julio Oscanoa , Irmak Sivgin , Cagan Alkan , Daniel Ennis , John Pauly , Mert Pilanci , Shreyas Vasanawala