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In domains such as molecular and protein generation, physical systems exhibit inherent symmetries that are critical to model. Two main strategies have emerged for learning invariant distributions: designing equivariant network architectures…

Machine Learning · Computer Science 2025-10-21 Vinh Tong , Hoang Trung-Dung , Anji Liu , Guy Van den Broeck , Mathias Niepert

De novo protein structure prediction from amino acid sequence is one of the most challenging problems in computational biology. As one of the extensively explored mathematical models for protein folding, Hydrophobic-Polar (HP) model enables…

Machine Learning · Computer Science 2018-12-06 Yanjun Li , Hengtong Kang , Ketian Ye , Shuyu Yin , Xiaolin Li

Diffusion Language Models (DLMs) have recently achieved strong results in text generation. However, their multi-step sampling leads to slow inference, limiting practical use. To address this, we extend Inverse Distillation, a technique…

Machine Learning · Computer Science 2026-02-24 David Li , Nikita Gushchin , Dmitry Abulkhanov , Eric Moulines , Ivan Oseledets , Maxim Panov , Alexander Korotin

Equipping a deep model the abaility of few-shot learning, i.e., learning quickly from only few examples, is a core challenge for artificial intelligence. Gradient-based meta-learning approaches effectively address the challenge by learning…

Machine Learning · Computer Science 2024-01-09 Baoquan Zhang , Chuyao Luo , Demin Yu , Huiwei Lin , Xutao Li , Yunming Ye , Bowen Zhang

This study introduces LRDif, a novel diffusion-based framework designed specifically for facial expression recognition (FER) within the context of under-display cameras (UDC). To address the inherent challenges posed by UDC's image…

Computer Vision and Pattern Recognition · Computer Science 2024-02-02 Zhifeng Wang , Kaihao Zhang , Ramesh Sankaranarayana

Diffusion models have emerged as powerful generative tools with applications in computer vision and scientific machine learning (SciML), where they have been used to solve large-scale probabilistic inverse problems. Traditionally, these…

This paper presents ThinkDiff, a novel alignment paradigm that empowers text-to-image diffusion models with multimodal in-context understanding and reasoning capabilities by integrating the strengths of vision-language models (VLMs).…

Machine Learning · Computer Science 2025-02-18 Zhenxing Mi , Kuan-Chieh Wang , Guocheng Qian , Hanrong Ye , Runtao Liu , Sergey Tulyakov , Kfir Aberman , Dan Xu

Multi-modal image fusion aims to consolidate complementary information from diverse source images into a unified representation. The fused image is expected to preserve fine details and maintain high visual fidelity. While diffusion models…

Computer Vision and Pattern Recognition · Computer Science 2026-01-29 Xingxin Xu , Bing Cao , DongDong Li , Qinghua Hu , Pengfei Zhu

Diffusion models are a class of flexible generative models trained with an approximation to the log-likelihood objective. However, most use cases of diffusion models are not concerned with likelihoods, but instead with downstream objectives…

Machine Learning · Computer Science 2024-01-08 Kevin Black , Michael Janner , Yilun Du , Ilya Kostrikov , Sergey Levine

Integrating grayscale and depth data in road inspection robots could enhance the accuracy, reliability, and comprehensiveness of road condition assessments, leading to improved maintenance strategies and safer infrastructure. However, these…

Computer Vision and Pattern Recognition · Computer Science 2024-10-15 Xiaoyan Jiang , Licheng Jiang , Anjie Wang , Kaiying Zhu , Yongbin Gao

The goal of protein design is to generate amino acid sequences that fold into functional structures with desired properties. Prior methods combining autoregressive language models with Monte Carlo Tree Search (MCTS) struggle with long-range…

Machine Learning · Computer Science 2026-02-25 Xuefeng Liu , Mingxuan Cao , Songhao Jiang , Xiao Luo , Xiaotian Duan , Mengdi Wang , Tobin R. Sosnick , Jinbo Xu , Rick Stevens

In the field of inverse estimation for systems modeled by partial differential equations (PDEs), challenges arise when estimating high- (or even infinite-) dimensional parameters. Typically, the ill-posed nature of such problems…

Computational Engineering, Finance, and Science · Computer Science 2024-08-30 Yankun Hong , Harshit Bansal , Karen Veroy

This paper introduces a novel framework for DNA sequence generation, comprising two key components: DiscDiff, a Latent Diffusion Model (LDM) tailored for generating discrete DNA sequences, and Absorb-Escape, a post-training algorithm…

Genomics · Quantitative Biology 2024-04-18 Zehui Li , Yuhao Ni , William A V Beardall , Guoxuan Xia , Akashaditya Das , Guy-Bart Stan , Yiren Zhao

We address the problem of fine-tuning diffusion models for reward-guided generation in biomolecular design. While diffusion models have proven highly effective in modeling complex, high-dimensional data distributions, real-world…

This tutorial provides an in-depth guide on inference-time guidance and alignment methods for optimizing downstream reward functions in diffusion models. While diffusion models are renowned for their generative modeling capabilities,…

Artificial Intelligence · Computer Science 2025-01-22 Masatoshi Uehara , Yulai Zhao , Chenyu Wang , Xiner Li , Aviv Regev , Sergey Levine , Tommaso Biancalani

We present the RAW domain diffusion model (RDDM), an end-to-end diffusion model that restores photo-realistic images directly from the sensor RAW data. While recent sRGB-domain diffusion methods achieve impressive results, they are caught…

Image and Video Processing · Electrical Eng. & Systems 2026-02-03 Yan Chen , Yi Wen , Wei Li , Junchao Liu , Yong Guo , Jie Hu , Xinghao Chen

Manipulating transparent objects presents significant challenges due to the complexities introduced by their reflection and refraction properties, which considerably hinder the accurate estimation of their 3D shapes. To address these…

Computer Vision and Pattern Recognition · Computer Science 2025-03-18 Haoxiao Wang , Kaichen Zhou , Binrui Gu , Zhiyuan Feng , Weijie Wang , Peilin Sun , Yicheng Xiao , Jianhua Zhang , Hao Dong

Diffusion-based data augmentation (DiffDA) has emerged as a promising approach to improving classification performance under data scarcity. However, existing works vary significantly in task configurations, model choices, and experimental…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Zekun Li , Yinghuan Shi , Yang Gao , Dong Xu

Denoising Diffusion Probabilistic Models (DDPMs) have recently achieved remarkable results in conditional and unconditional image generation. The pre-trained models can be adapted without further training to different downstream tasks, by…

Computer Vision and Pattern Recognition · Computer Science 2023-09-19 Asya Grechka , Guillaume Couairon , Matthieu Cord

Employing a forward diffusion chain to gradually map the data to a noise distribution, diffusion-based generative models learn how to generate the data by inferring a reverse diffusion chain. However, this approach is slow and costly…

Machine Learning · Statistics 2023-09-08 Huangjie Zheng , Pengcheng He , Weizhu Chen , Mingyuan Zhou
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