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Large language models (LLMs) show promise for supporting clinicians in diagnostic communication by generating explanations and guidance for patients. Yet their ability to produce outputs that are both understandable and empathetic remains…

Computation and Language · Computer Science 2025-11-04 Jianzhou Yao , Shunchang Liu , Guillaume Drui , Rikard Pettersson , Alessandro Blasimme , Sara Kijewski

Understanding why a large language model (LLM) is uncertain about the response is important for their reliable deployment. Current approaches, which either provide a single uncertainty score or rely on the classical aleatoric-epistemic…

Artificial Intelligence · Computer Science 2026-03-27 Aditya Taparia , Ransalu Senanayake , Kowshik Thopalli , Vivek Narayanaswamy

Large language models (LLMs) are known to abandon their initial stance to conform to user pushback. While prior research largely attributes this behavior to sycophancy learned during reinforcement learning from human feedback, we…

Computation and Language · Computer Science 2026-05-27 Kevin H. Guo , Chao Yan , Avinash Baidya , Katherine Brown , Xiang Gao , Juming Xiong , Zhijun Yin , Bradley A. Malin

Large Language Models (LLMs) have become increasingly pervasive, finding applications across many industries and disciplines. Ensuring the trustworthiness of LLM outputs is paramount, where Uncertainty Estimation (UE) plays a key role. In…

Computation and Language · Computer Science 2025-11-06 Kevin Wang , Subre Abdoul Moktar , Jia Li , Kangshuo Li , Feng Chen

Large Language Models (LLMs) are increasingly deployed for clinical reasoning tasks, which inherently require eliciting calibrated probabilistic beliefs based on available evidence. However, real-world clinical data are frequently…

Artificial Intelligence · Computer Science 2026-03-19 Yuta Kobayashi , Vincent Jeanselme , Shalmali Joshi

An interesting behavior in large language models (LLMs) is prompt sensitivity. When provided with different but semantically equivalent versions of the same prompt, models may produce very different distributions of answers. This suggests…

Computation and Language · Computer Science 2025-10-21 Kyle Cox , Jiawei Xu , Yikun Han , Rong Xu , Tianhao Li , Chi-Yang Hsu , Tianlong Chen , Walter Gerych , Ying Ding

Large language models (LLMs) have demonstrated impressive performance across various domains. However, for clinical diagnosis, higher expectations are required for LLM's reliability and sensitivity: thinking like physicians and remaining…

Computation and Language · Computer Science 2025-04-21 Chenwei Yan , Xiangling Fu , Yuxuan Xiong , Tianyi Wang , Siu Cheung Hui , Ji Wu , Xien Liu

The proliferation of open-source Large Language Models (LLMs) from various institutions has highlighted the urgent need for comprehensive evaluation methods. However, current evaluation platforms, such as the widely recognized HuggingFace…

Computation and Language · Computer Science 2024-11-01 Fanghua Ye , Mingming Yang , Jianhui Pang , Longyue Wang , Derek F. Wong , Emine Yilmaz , Shuming Shi , Zhaopeng Tu

Large-language models (LLMs) and chatbot agents are known to provide wrong outputs at times, and it was recently found that this can never be fully prevented. Hence, uncertainty quantification plays a crucial role, aiming to quantify the…

Machine Learning · Computer Science 2025-05-29 Michael Kirchhof , Gjergji Kasneci , Enkelejda Kasneci

In recent years, Large Language Models (LLMs) have become fundamental to a broad spectrum of artificial intelligence applications. As the use of LLMs expands, precisely estimating the uncertainty in their predictions has become crucial.…

Artificial Intelligence · Computer Science 2024-10-29 Mohammad Beigi , Sijia Wang , Ying Shen , Zihao Lin , Adithya Kulkarni , Jianfeng He , Feng Chen , Ming Jin , Jin-Hee Cho , Dawei Zhou , Chang-Tien Lu , Lifu Huang

Advances in the general capabilities of large language models (LLMs) have led to their use for information retrieval, and as components in automated decision systems. A faithful representation of probabilistic reasoning in these models may…

Artificial Intelligence · Computer Science 2025-04-21 Gabriel Freedman , Francesca Toni

Large language models (LLMs) have delivered significant breakthroughs across diverse domains but can still produce unreliable or misleading outputs, posing critical challenges for real-world applications. While many recent studies focus on…

Computation and Language · Computer Science 2025-09-08 Yang Nan , Pengfei He , Ravi Tandon , Han Xu

Large Language Models (LLMs) have been widely employed in programming language analysis to enhance human productivity. Yet, their reliability can be compromised by various code distribution shifts, leading to inconsistent outputs. While…

Software Engineering · Computer Science 2024-02-12 Yufei Li , Simin Chen , Yanghong Guo , Wei Yang , Yue Dong , Cong Liu

As large language models (LLMs) are increasingly deployed in high-stakes applications, robust uncertainty estimation is essential for ensuring the safe and trustworthy deployment of LLMs. We present the most comprehensive study to date of…

Computation and Language · Computer Science 2025-06-02 Linwei Tao , Yi-Fan Yeh , Minjing Dong , Tao Huang , Philip Torr , Chang Xu

Large language models (LLMs) are becoming increasingly relevant as a potential tool for healthcare, aiding communication between clinicians, researchers, and patients. However, traditional evaluations of LLMs on medical exam questions do…

Computation and Language · Computer Science 2023-09-19 Rojin Ziaei , Samuel Schmidgall

In-context learning has emerged as a groundbreaking ability of Large Language Models (LLMs) and revolutionized various fields by providing a few task-relevant demonstrations in the prompt. However, trustworthy issues with LLM's response,…

Computation and Language · Computer Science 2024-04-01 Chen Ling , Xujiang Zhao , Xuchao Zhang , Wei Cheng , Yanchi Liu , Yiyou Sun , Mika Oishi , Takao Osaki , Katsushi Matsuda , Jie Ji , Guangji Bai , Liang Zhao , Haifeng Chen

Large language models (LLMs) are increasingly used as epistemic partners in everyday reasoning, yet their errors remain predominantly analyzed through predictive metrics rather than through their interpretive effects on human judgment. This…

Human-Computer Interaction · Computer Science 2025-12-19 Claudia Vale Oliveira , Nelson Zagalo , Filipe Silva , Anabela Brandao , Syeda Faryal Hussain Khurrum , Joaquim Santos

Although large language models (LLMs) are highly interactive and extendable, current approaches to ensure reliability in deployments remain mostly limited to rejecting outputs with high uncertainty in order to avoid misinformation. This…

Machine Learning · Computer Science 2025-06-10 T. Duy Nguyen-Hien , Desi R. Ivanova , Yee Whye Teh , Wee Sun Lee

In recent years, large-scale language models (LLMs) have gained attention for their impressive text generation capabilities. However, these models often face the challenge of "hallucination," which undermines their reliability. In this…

Computation and Language · Computer Science 2023-10-10 Yuchen Yang , Houqiang Li , Yanfeng Wang , Yu Wang

Large Language Models (LLMs) are prone to generating fluent but incorrect content, known as confabulation, which poses increasing risks in multi-turn or agentic applications where outputs may be reused as context. In this work, we…

Computation and Language · Computer Science 2026-03-18 Tianyi Zhou , Johanne Medina , Sanjay Chawla