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As large language models (LLMs) are increasingly used in high-stakes domains, accurately assessing their confidence is crucial. Humans typically express confidence through epistemic markers (e.g., "fairly confident") instead of numerical…

Computation and Language · Computer Science 2026-04-14 Jiayu Liu , Qing Zong , Weiqi Wang , Yangqiu Song

This study investigates uncertainty quantification in large language models (LLMs) for medical applications, emphasizing both technical innovations and philosophical implications. As LLMs become integral to clinical decision-making,…

Artificial Intelligence · Computer Science 2025-04-08 Zahra Atf , Seyed Amir Ahmad Safavi-Naini , Peter R. Lewis , Aref Mahjoubfar , Nariman Naderi , Thomas R. Savage , Ali Soroush

LLMs' linguistically expressed confidence should faithfully reflect their intrinsic uncertainty. While recent work shows LLMs struggle to use epistemic markers (e.g., "it is likely...") in a human-aligned fashion, it remains unclear whether…

Computation and Language · Computer Science 2026-05-28 Gabrielle Kaili-May Liu , Arman Cohan

With the widespread application of Large Language Models (LLMs) to various domains, concerns regarding the trustworthiness of LLMs in safety-critical scenarios have been raised, due to their unpredictable tendency to hallucinate and…

Computation and Language · Computer Science 2024-11-04 Xin Qiu , Risto Miikkulainen

Large language models are increasingly relied upon as sources of information, but their propensity for generating false or misleading statements with high confidence poses risks for users and society. In this paper, we confront the critical…

Large Language Models (LLMs) are increasingly used as powerful tools for several high-stakes natural language processing (NLP) applications. Recent prompting works claim to elicit intermediate reasoning steps and key tokens that serve as…

Computation and Language · Computer Science 2023-11-08 Sree Harsha Tanneru , Chirag Agarwal , Himabindu Lakkaraju

We posit that large language models (LLMs) should be capable of expressing their intrinsic uncertainty in natural language. For example, if the LLM is equally likely to output two contradicting answers to the same question, then its…

Computation and Language · Computer Science 2024-09-27 Gal Yona , Roee Aharoni , Mor Geva

Clinical decision-making requires reasoning over incomplete, imprecise, and linguistically expressed patient narratives. While large language models (LLMs) excel at extracting latent information from natural language, they lack the…

Artificial Intelligence · Computer Science 2026-05-26 Xiaoyang Fan , Yufan Cai , Zhe Hou , Jin Song Dong

Can large language models (LLMs) express their uncertainty in situations where they lack sufficient parametric knowledge to generate reasonable responses? This work aims to systematically investigate LLMs' behaviors in such situations,…

Computation and Language · Computer Science 2024-02-19 Genglin Liu , Xingyao Wang , Lifan Yuan , Yangyi Chen , Hao Peng

Large language models (LLMs) are increasingly employed in information-seeking and decision-making tasks. Despite their broad utility, LLMs tend to generate information that conflicts with real-world facts, and their persuasive style can…

Computation and Language · Computer Science 2024-09-19 Arslan Chaudhry , Sridhar Thiagarajan , Dilan Gorur

Human users increasingly communicate with large language models (LLMs), but LLMs suffer from frequent overconfidence in their output, even when its accuracy is questionable, which undermines their trustworthiness and perceived legitimacy.…

Computation and Language · Computer Science 2026-02-23 Dennis Ulmer , Alexandra Lorson , Ivan Titov , Christian Hardmeier

We explore uncertainty quantification in large language models (LLMs), with the goal to identify when uncertainty in responses given a query is large. We simultaneously consider both epistemic and aleatoric uncertainties, where the former…

Machine Learning · Computer Science 2024-07-18 Yasin Abbasi Yadkori , Ilja Kuzborskij , András György , Csaba Szepesvári

The increased deployment of LMs for real-world tasks involving knowledge and facts makes it important to understand model epistemology: what LMs think they know, and how their attitudes toward that knowledge are affected by language use in…

Computation and Language · Computer Science 2023-11-14 Kaitlyn Zhou , Dan Jurafsky , Tatsunori Hashimoto

As large language models (LLMs) continue to evolve, understanding and quantifying the uncertainty in their predictions is critical for enhancing application credibility. However, the existing literature relevant to LLM uncertainty…

Computation and Language · Computer Science 2024-10-22 Hsiu-Yuan Huang , Yutong Yang , Zhaoxi Zhang , Sanwoo Lee , Yunfang Wu

Large language models (LLMs) are increasingly used in high-stakes settings, where overconfident responses can mislead users. Reliable confidence estimation has been shown to enhance trust and task accuracy. Yet existing methods face…

Computation and Language · Computer Science 2025-09-30 Linwei Tao , Yi-Fan Yeh , Bo Kai , Minjing Dong , Tao Huang , Tom A. Lamb , Jialin Yu , Philip H. S. Torr , Chang Xu

Rational speakers are supposed to know what they know and what they do not know, and to generate expressions matching the strength of evidence. In contrast, it is still a challenge for current large language models to generate corresponding…

Computation and Language · Computer Science 2025-06-03 Meng Li , Michael Vrazitulis , David Schlangen

We study the feasibility of identifying epistemic uncertainty (reflecting a lack of knowledge), as opposed to aleatoric uncertainty (reflecting entropy in the underlying distribution), in the outputs of large language models (LLMs) over…

Machine Learning · Computer Science 2024-02-28 Gustaf Ahdritz , Tian Qin , Nikhil Vyas , Boaz Barak , Benjamin L. Edelman

Clinical Decision Support Systems (CDSS) utilize evidence-based knowledge and patient data to offer real-time recommendations, with Large Language Models (LLMs) emerging as a promising tool to generate plain-text explanations for medical…

Computation and Language · Computer Science 2023-10-04 D. Umerenkov , G. Zubkova , A. Nesterov

Accurately quantifying uncertainty in large language models (LLMs) is crucial for their reliable deployment, especially in high-stakes applications. Current state-of-the-art methods for measuring semantic uncertainty in LLMs rely on strict…

Machine Learning · Computer Science 2024-10-31 Yashvir S. Grewal , Edwin V. Bonilla , Thang D. Bui

Explainable disease diagnosis, which leverages patient information (e.g., signs and symptoms) and computational models to generate probable diagnoses and reasonings, offers clear clinical values. However, when clinical notes encompass…

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