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Histo-genomic multi-modal methods have recently emerged as a powerful paradigm, demonstrating significant potential for improving cancer prognosis. However, genome sequencing, unlike histopathology imaging, is still not widely accessible in…

Image and Video Processing · Electrical Eng. & Systems 2024-03-19 Zhikang Wang , Yumeng Zhang , Yingxue Xu , Seiya Imoto , Hao Chen , Jiangning Song

Sleep stage classification is crucial for detecting patients' health conditions. Existing models, which mainly use Convolutional Neural Networks (CNN) for modelling Euclidean data and Graph Convolution Networks (GNN) for modelling…

Machine Learning · Computer Science 2023-09-06 Yuze Liu , Ziming Zhao , Tiehua Zhang , Kang Wang , Xin Chen , Xiaowei Huang , Jun Yin , Zhishu Shen

Learning good representation of giga-pixel level whole slide pathology images (WSI) for downstream tasks is critical. Previous studies employ multiple instance learning (MIL) to represent WSIs as bags of sampled patches because, for most…

Computer Vision and Pattern Recognition · Computer Science 2022-12-01 Chunyuan Li , Xinliang Zhu , Jiawen Yao , Junzhou Huang

Multimodal learning that integrates histopathology images and genomic data holds great promise for cancer survival prediction. However, existing methods face key limitations: 1) They rely on multimodal mapping and metrics in Euclidean…

Computer Vision and Pattern Recognition · Computer Science 2025-03-19 Jiaqi Yang , Wenting Chen , Xiaohan Xing , Sean He , Xiaoling Luo , Xinheng Lyu , Linlin Shen , Guoping Qiu

Pathology is essential for cancer diagnosis, with multiple instance learning (MIL) widely used for whole slide image (WSI) analysis. WSIs exhibit a natural hierarchy -- patches, regions, and slides -- with distinct semantic associations.…

Computer Vision and Pattern Recognition · Computer Science 2025-07-01 Peixiang Huang , Yanyan Huang , Weiqin Zhao , Junjun He , Lequan Yu

When a high-resolution (HR) image is degraded into a low-resolution (LR) image, the image loses some of the existing information. Consequently, multiple HR images can correspond to the LR image. Most of the existing methods do not consider…

Computer Vision and Pattern Recognition · Computer Science 2022-07-19 Hanbyel Cho , Yekang Lee , Jaemyung Yu , Junmo Kim

Finding meaningful representations and distances of hierarchical data is important in many fields. This paper presents a new method for hierarchical data embedding and distance. Our method relies on combining diffusion geometry, a central…

Machine Learning · Computer Science 2023-05-31 Ya-Wei Eileen Lin , Ronald R. Coifman , Gal Mishne , Ronen Talmon

Hyperspectral image (HSI) denoising is an essential procedure for HSI applications. Unfortunately, the existing Transformer-based methods mainly focus on non-local modeling, neglecting the importance of locality in image denoising.…

Image and Video Processing · Electrical Eng. & Systems 2024-08-05 Hao Liang , Chengjie , Kun Li , Xin Tian

Language models are increasingly applied to biological sequences like proteins and mRNA, yet their default Euclidean geometry may mismatch the hierarchical structures inherent to biological data. While hyperbolic geometry provides a better…

Machine Learning · Computer Science 2025-11-05 Max van Spengler , Artem Moskalev , Tommaso Mansi , Mangal Prakash , Rui Liao

Gene expression profiling provides profound insights into molecular mechanisms, but its time-consuming and costly nature often presents significant challenges. In contrast, whole-slide hematoxylin and eosin (H&E) stained histological images…

Computer Vision and Pattern Recognition · Computer Science 2024-11-28 Ying Xiong , Linjing Liu , Yufei Cui , Shangyu Wu , Xue Liu , Antoni B. Chan , Chun Jason Xue

In multivariate time series (MTS) forecasting, many deep learning based methods have been proposed for modeling dependencies at multiple spatial (inter-variate) or temporal (intra-variate) scales. However, existing methods may fail to model…

Machine Learning · Computer Science 2025-09-03 Binqing Wu , Jianlong Huang , Zongjiang Shang , Ling Chen

Spatial transcriptomics (ST) enables spot-level in situ expression profiling, but its high cost and limited throughput motivate predicting expression directly from HE-stained histology. Recent advances explore using score- or flow-based…

Computer Vision and Pattern Recognition · Computer Science 2026-03-23 Donghai Fang , Yongheng Li , Zhen Wang , Yuansong Zeng , Wenwen Min

Learning in hyperbolic spaces has attracted increasing attention due to its superior ability to model hierarchical structures of data. Most existing hyperbolic learning methods use fixed distance measures for all data, assuming a uniform…

Computer Vision and Pattern Recognition · Computer Science 2025-06-24 Pengxiang Li , Yuwei Wu , Zhi Gao , Xiaomeng Fan , Wei Wu , Zhipeng Lu , Yunde Jia , Mehrtash Harandi

Traditional feature extraction and projection techniques, such as Principal Component Analysis, struggle to adequately represent X-Ray Transmission (XRT) Multi-Energy (ME) images, limiting the performance of neural networks in…

Computer Vision and Pattern Recognition · Computer Science 2025-11-19 Fethi Harkat , Guillaume Gey , Valérie Perrier , Kévin Polisano , Tiphaine Deuberet

This paper addresses the problem of geometric scene parsing, i.e. simultaneously labeling geometric surfaces (e.g. sky, ground and vertical plane) and determining the interaction relations (e.g. layering, supporting, siding and affinity)…

Computer Vision and Pattern Recognition · Computer Science 2016-04-11 Zhanglin Peng , Ruimao Zhang , Xiaodan Liang , Xiaobai Liu , Liang Lin

Spatial transcriptomics data analysis integrates cellular transcriptional activity with spatial coordinates to identify spatial domains, infer cell-type dynamics, and characterize gene expression patterns within tissues. Despite recent…

Quantitative Methods · Quantitative Biology 2026-03-25 Sean Cottrell , Guo-Wei Wei , Longxiu Huang

The progress in hyperbolic neural networks (HNNs) research is hindered by their absence of inductive bias mechanisms, which are essential for generalizing to new tasks and facilitating scalable learning over large datasets. In this paper,…

Machine Learning · Computer Science 2023-10-31 Nurendra Choudhary , Nikhil Rao , Chandan K. Reddy

Hyperspectral imaging, also known as image spectrometry, is a landmark technique in geoscience and remote sensing (RS). In the past decade, enormous efforts have been made to process and analyze these hyperspectral (HS) products mainly by…

Computer Vision and Pattern Recognition · Computer Science 2021-03-03 Danfeng Hong , Wei He , Naoto Yokoya , Jing Yao , Lianru Gao , Liangpei Zhang , Jocelyn Chanussot , Xiao Xiang Zhu

Recently, Hyperbolic Spaces in the context of Non-Euclidean Deep Learning have gained popularity because of their ability to represent hierarchical data. We propose that it is possible to take advantage of the hierarchical characteristic…

Machine Learning · Computer Science 2021-02-11 Diego Lazcano , Nicolás Fredes , Werner Creixell

Histopathology remains the gold standard for cancer diagnosis and prognosis. With the advent of transcriptome profiling, multi-modal learning combining transcriptomics with histology offers more comprehensive information. However, existing…

Image and Video Processing · Electrical Eng. & Systems 2026-03-03 Yupei Zhang , Xiaofei Wang , Anran Liu , Lequan Yu , Chao Li