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Large Language Models (LLMs) are composed of neurons that exhibit various behaviors and roles, which become increasingly diversified as models scale. Recent studies have revealed that not all neurons are active across different datasets,…

Computation and Language · Computer Science 2024-03-19 Haoyun Xu , Runzhe Zhan , Derek F. Wong , Lidia S. Chao

We introduce a low-resource safety enhancement method for aligning large language models (LLMs) without the need for supervised fine-tuning (SFT) or reinforcement learning from human feedback (RLHF). Our main idea is to exploit knowledge…

Computation and Language · Computer Science 2024-06-07 Haozheng Luo , Jiahao Yu , Wenxin Zhang , Jialong Li , Jerry Yao-Chieh Hu , Xinyu Xing , Han Liu

The scarcity of high-quality multimodal biomedical data limits the ability to effectively fine-tune pretrained Large Language Models (LLMs) for specialized biomedical tasks. To address this challenge, we introduce MINT (Multimodal…

Quantitative Methods · Quantitative Biology 2026-02-18 Zhanliang Wang , Da Wu , Quan Nguyen , Zhuoran Xu , Kai Wang

The widespread adoption of Low-Rank Adaptation (LoRA) has enabled large language models (LLMs) to acquire domain-specific knowledge with remarkable efficiency. However, understanding how such a fine-tuning mechanism alters a model's…

Machine Learning · Computer Science 2025-09-26 Yucheng Wang , Ziyang Chen , Md Faisal Kabir

Large Language Models (LLMs), particularly those similar to ChatGPT, have significantly influenced the field of Natural Language Processing (NLP). While these models excel in general language tasks, their performance in domain-specific…

Computation and Language · Computer Science 2024-01-02 Omid Rohanian , Mohammadmahdi Nouriborji , David A. Clifton

Multimodal large language models (MLLMs) have made rapid progress, yet their reasoning ability often lags behind strong text-only LLMs. Bridging this gap typically requires large-scale multimodal reasoning data or reinforcement learning,…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Chao Huang , Zeliang Zhang , Jiang Liu , Ximeng Sun , Jialian Wu , Xiaodong Yu , Ze Wang , Chenliang Xu , Emad Barsoum , Zicheng Liu

Reinforcement Learning with Human Feedback (RLHF) is the key to the success of large language models (LLMs) in recent years. In this work, we first introduce the concepts of knowledge breadth and knowledge depth, which measure the…

Computation and Language · Computer Science 2025-02-21 Sizhe Wang , Yongqi Tong , Hengyuan Zhang , Dawei Li , Xin Zhang , Tianlong Chen

The massive scale and growth of textual biomedical data have made its indexing and classification increasingly important. However, existing research on this topic mainly utilized convolutional and recurrent neural networks, which generally…

Computation and Language · Computer Science 2022-03-08 Bruce Nguyen , Shaoxiong Ji

Large semantic knowledge bases are grounded in factual knowledge. However, recent approaches to dense text representations (i.e. embeddings) do not efficiently exploit these resources. Dense and robust representations of documents are…

Artificial Intelligence · Computer Science 2024-10-01 Boshko Koloski , Senja Pollak , Roberto Navigli , Blaž Škrlj

Alignment, endowing a pre-trained Large language model (LLM) with the ability to follow instructions, is crucial for its real-world applications. Conventional supervised fine-tuning (SFT) methods formalize it as causal language modeling…

Computation and Language · Computer Science 2024-12-18 Yuchen Fan , Yuzhong Hong , Qiushi Wang , Junwei Bao , Hongfei Jiang , Yang Song

This paper introduces a pioneering methodology, termed StructTuning, to efficiently transform foundation Large Language Models (LLMs) into domain specialists. It significantly reduces the training corpus needs to a mere 5% while achieving…

Computation and Language · Computer Science 2025-02-18 Kai Liu , Ze Chen , Zhihang Fu , Wei Zhang , Rongxin Jiang , Fan Zhou , Yaowu Chen , Yue Wu , Jieping Ye

Supervised fine-tuning (SFT) followed by reinforcement learning (RL) has become a standard post-training paradigm for large language models. This paradigm provides a cold-start for RL exploration, avoiding the inefficiency of pure RL where…

Artificial Intelligence · Computer Science 2026-05-29 Qi Liu , Mingdi Sun , Yongyi He , Zhi Zheng , Tong Xu , Yi Zheng , Zhefeng Wang , Enhong Chen

Large language models (LLMs) consistently benefit from further fine-tuning on various tasks. However, we observe that directly tuning the Instruct (i.e., instruction-tuned) models often leads to marginal improvements and even performance…

Computation and Language · Computer Science 2025-09-29 Taiqiang Wu , Runming Yang , Jiayi Li , Pengfei Hu , Yik-Chung Wu , Ngai Wong , Yujiu Yang

Recent advances in large language models (LLMs) have significantly improved the alignment of models with general human preferences. However, a major challenge remains in adapting LLMs to individual preferences, which are not only diverse…

Computation and Language · Computer Science 2026-04-15 Shanyong Wang , Shuhang Lin , Yining Zhao , Xi Zhu , Yongfeng Zhang

The recent success of Large Language Models (LLMs) has gained significant attention in both academia and industry. Substantial efforts have been made to enhance the zero- and few-shot generalization capabilities of open-source LLMs through…

Computation and Language · Computer Science 2023-10-03 Zongxi Li , Xianming Li , Yuzhang Liu , Haoran Xie , Jing Li , Fu-lee Wang , Qing Li , Xiaoqin Zhong

Large language models (LLMs) have exhibited impressive reasoning abilities on a wide range of complex tasks. However, enhancing these capabilities through post-training remains resource intensive, particularly in terms of data and…

Artificial Intelligence · Computer Science 2025-08-13 Shuo Cai , Su Lu , Qi Zhou , Kejing Yang , Zhijie Sang , Congkai Xie , Hongxia Yang

Large Language Models (LLMs) currently respond to every prompt. However, they can produce incorrect answers when they lack knowledge or capability -- a problem known as hallucination. We instead propose post-training an LLM to generate…

Computation and Language · Computer Science 2026-02-17 Tim Franzmeyer , Archie Sravankumar , Lijuan Liu , Yuning Mao , Rui Hou , Sinong Wang , Jakob N. Foerster , Luke Zettlemoyer , Madian Khabsa

Biomedical knowledge is growing in an astounding pace with a majority of this knowledge is represented as scientific publications. Text mining tools and methods represents automatic approaches for extracting hidden patterns and trends from…

Information Retrieval · Computer Science 2026-03-03 Balu Bhasuran , Gurusamy Murugesan , Jeyakumar Natarajan

Recent advances in large language models (LLMs) have enhanced their ability to process long input contexts. This development is particularly crucial for tasks that involve retrieving knowledge from an external datastore, which can result in…

Computation and Language · Computer Science 2024-04-03 Zheng Zhang , Fan Yang , Ziyan Jiang , Zheng Chen , Zhengyang Zhao , Chengyuan Ma , Liang Zhao , Yang Liu

As foundation models continue to exponentially scale in size, efficient methods of adaptation become increasingly critical. Parameter-efficient fine-tuning (PEFT), a recent class of techniques that require only modifying a small percentage…

Computation and Language · Computer Science 2023-05-01 George Pu , Anirudh Jain , Jihan Yin , Russell Kaplan