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Sepsis is the leading cause of mortality in the ICU. It is challenging to manage because individual patients respond differently to treatment. Thus, tailoring treatment to the individual patient is essential for the best outcomes. In this…

Designing reward functions for reinforcement learning (RL) in healthcare remains challenging because clinically meaningful outcomes are sparse, delayed, and difficult to explicitly specify. Although structured clinical data capture…

Artificial Intelligence · Computer Science 2026-05-26 Daniel J. Tan , Jayne Hui Zhen Chan , Kai Wen Hwang , Arturo Yong Yao Neo , Kay Choong See , Mengling Feng

Managing physiological variables within clinically safe target zones is a central challenge in healthcare, particularly for chronic conditions such as Type 1 Diabetes Mellitus (T1DM). Reinforcement learning (RL) offers promise for…

Machine Learning · Computer Science 2025-08-07 David H. Mguni , Jing Dong , Wanrong Yang , Ziquan Liu , Muhammad Salman Haleem , Baoxiang Wang

Temporal Difference (TD) algorithms are widely used in Deep Reinforcement Learning (RL). Their performance is heavily influenced by the size of the neural network. While in supervised learning, the regime of over-parameterization and its…

Machine Learning · Computer Science 2024-02-20 David Brellmann , Eloïse Berthier , David Filliat , Goran Frehse

Reward engineering is an important aspect of reinforcement learning. Whether or not the user's intentions can be correctly encapsulated in the reward function can significantly impact the learning outcome. Current methods rely on manually…

Artificial Intelligence · Computer Science 2017-09-28 Xiao Li , Yao Ma , Calin Belta

Reinforcement learning is able to solve complex sequential decision-making tasks but is currently limited by sample efficiency and required computation. To improve sample efficiency, recent work focuses on model-based RL which interleaves…

Machine Learning · Computer Science 2023-06-19 Yi Zhao , Wenshuai Zhao , Rinu Boney , Juho Kannala , Joni Pajarinen

Test-Time Scaling (TTS) is an important method for improving the performance of Large Language Models (LLMs) by using additional computation during the inference phase. However, current studies do not systematically analyze how policy…

Computation and Language · Computer Science 2025-02-11 Runze Liu , Junqi Gao , Jian Zhao , Kaiyan Zhang , Xiu Li , Biqing Qi , Wanli Ouyang , Bowen Zhou

Continual Learning requires the model to learn from a stream of dynamic, non-stationary data without forgetting previous knowledge. Several approaches have been developed in the literature to tackle the Continual Learning challenge. Among…

Machine Learning · Computer Science 2022-11-30 Gabriele Merlin , Vincenzo Lomonaco , Andrea Cossu , Antonio Carta , Davide Bacciu

Reinforcement learning (RL) in the real world necessitates the development of procedures that enable agents to explore without causing harm to themselves or others. The most successful solutions to the problem of safe RL leverage offline…

Machine Learning · Computer Science 2025-01-09 Alexander Quessy , Thomas Richardson , Sebastian East

We propose a new approach to value function approximation which combines linear temporal difference reinforcement learning with subspace identification. In practical applications, reinforcement learning (RL) is complicated by the fact that…

Machine Learning · Computer Science 2015-03-17 Byron Boots , Geoffrey J. Gordon

A large and diverse set of measurements are regularly collected during a patient's hospital stay to monitor their health status. Tools for integrating these measurements into severity scores, that accurately track changes in illness…

Artificial Intelligence · Computer Science 2015-11-13 Kirill Dyagilev , Suchi Saria

The use of reinforcement learning (RL) methods to support health behavior change via personalized and just-in-time adaptive interventions is of significant interest to health and behavioral science researchers focused on problems such as…

Machine Learning · Computer Science 2025-07-08 Karine Karine , Benjamin M. Marlin

Reinforcement learning (RL) has emerged as a powerful post-training technique to incentivize the reasoning ability of large language models (LLMs). However, LLMs can respond very inconsistently to RL finetuning: some show substantial…

Machine Learning · Computer Science 2025-10-07 Zhepeng Cen , Yihang Yao , William Han , Zuxin Liu , Ding Zhao

In complex reinforcement learning (RL) problems, policies with similar rewards may have substantially different behaviors. It remains a fundamental challenge to optimize rewards while also discovering as many diverse strategies as possible,…

Machine Learning · Computer Science 2023-10-24 Wei Fu , Weihua Du , Jingwei Li , Sunli Chen , Jingzhao Zhang , Yi Wu

One of the main goals of reinforcement learning (RL) is to provide a~way for physical machines to learn optimal behavior instead of being programmed. However, effective control of the machines usually requires fine time discretization. The…

Machine Learning · Computer Science 2022-07-12 Jakub Łyskawa , Paweł Wawrzyński

Safe and interpretable sequential decision-making is critical in healthcare, yet reinforcement learning (RL) policies for sepsis treatment optimization remain opaque and difficult to verify. Standard probabilistic model checkers operate on…

Artificial Intelligence · Computer Science 2026-02-17 Dennis Gross

Large reasoning models (LRMs) are commonly trained with reinforcement learning (RL) to explore long chain-of-thought reasoning, achieving strong performance at high computational cost. Recent methods add multi-reward objectives to jointly…

Artificial Intelligence · Computer Science 2026-02-17 Anhao Zhao , Ziyang Chen , Junlong Tong , Yingqi Fan , Fanghua Ye , Shuhao Li , Yunpu Ma , Wenjie Li , Xiaoyu Shen

In recent years, on-policy reinforcement learning (RL) has been successfully applied to many different continuous control tasks. While RL algorithms are often conceptually simple, their state-of-the-art implementations take numerous low-…

To optimize mobile health interventions and advance domain knowledge on intervention design, it is critical to understand how the intervention effect varies over time and with contextual information. This study aims to assess how a push…

Applications · Statistics 2024-10-22 Jiaxin Yu , Tianchen Qian

In sequential decision-making problems, Return-Conditioned Supervised Learning (RCSL) has gained increasing recognition for its simplicity and stability in modern decision-making tasks. Unlike traditional offline reinforcement learning (RL)…

Machine Learning · Computer Science 2025-06-11 Zhishuai Liu , Yu Yang , Ruhan Wang , Pan Xu , Dongruo Zhou
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