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Clinical reasoning in medicine is a hypothesis-driven process where physicians refine diagnoses from limited information through targeted history, physical examination, and diagnostic investigations. In contrast, current medical benchmarks…

Machine Learning · Computer Science 2025-10-14 Christopher Chiu , Silviu Pitis , Mihaela van der Schaar

Understanding the relationship between textual news and time-series evolution is a critical yet under-explored challenge in applied data science. While multimodal learning has gained traction, existing multimodal time-series datasets fall…

Computation and Language · Computer Science 2026-02-12 Jialin Chen , Aosong Feng , Ziyu Zhao , Juan Garza , Gaukhar Nurbek , Cheng Qin , Ali Maatouk , Leandros Tassiulas , Yifeng Gao , Rex Ying

As opposed to evaluating computation and logic-based reasoning, current benchmarks for evaluating large language models (LLMs) in medicine are primarily focused on question-answering involving domain knowledge and descriptive reasoning.…

Large Language Models (LLMs) have shown impressive performance on existing medical question-answering benchmarks. This high performance makes it increasingly difficult to meaningfully evaluate and differentiate advanced methods. We present…

Computation and Language · Computer Science 2025-03-21 Xiangru Tang , Daniel Shao , Jiwoong Sohn , Jiapeng Chen , Jiayi Zhang , Jinyu Xiang , Fang Wu , Yilun Zhao , Chenglin Wu , Wenqi Shi , Arman Cohan , Mark Gerstein

Background: The rapid integration of foundation models into clinical practice and public health necessitates a rigorous evaluation of their true clinical reasoning capabilities beyond narrow examination success. Current benchmarks,…

Computer Vision and Pattern Recognition · Computer Science 2025-12-30 Dingyu Wang , Zimu Yuan , Jiajun Liu , Shanggui Liu , Nan Zhou , Tianxing Xu , Di Huang , Dong Jiang

Multimodal artificial intelligence (AI) systems have the potential to enhance clinical decision-making by interpreting various types of medical data. However, the effectiveness of these models across all medical fields is uncertain. Each…

Large Language Models (LLMs) are increasingly excelling and outpacing human performance on many tasks. However, to improve LLM reasoning, researchers either rely on ad-hoc generated datasets or formal mathematical proof systems such as the…

Artificial Intelligence · Computer Science 2025-11-03 Nikolaus Holzer , William Fishell , Baishakhi Ray , Mark Santolucito

Large language models (LLMs) have achieved strong performance on medical exam-style tasks, motivating growing interest in their deployment in real-world clinical settings. However, clinical decision-making is inherently safety-critical,…

Computation and Language · Computer Science 2026-04-13 Xiaohan Ren , Chenxiao Fan , Wenyin Ma , Hongliang He , Chongming Gao , Xiaoyan Zhao , Fuli Feng

Multimodal reasoning, which integrates language and visual cues into problem solving and decision making, is a fundamental aspect of human intelligence and a crucial step toward artificial general intelligence. However, the evaluation of…

Large language models (LLMs) have become increasingly pivotal across various domains, especially in handling complex data types. This includes structured data processing, as exemplified by ChartQA and ChatGPT-Ada, and multimodal…

The rapid advancement of Multimodal Large Language Models (MLLMs) has been accompanied by the development of various benchmarks to evaluate their capabilities. However, the true nature of these evaluations and the extent to which they…

Computation and Language · Computer Science 2024-10-17 Botian Jiang , Lei Li , Xiaonan Li , Zhaowei Li , Xiachong Feng , Lingpeng Kong , Qi Liu , Xipeng Qiu

Natural language processing evaluation has made significant progress, largely driven by the proliferation of powerful large language mod-els (LLMs). New evaluation benchmarks are of increasing priority as the reasoning capabilities of LLMs…

Computation and Language · Computer Science 2025-06-19 Joseph J. Peper , Wenzhao Qiu , Ali Payani , Lu Wang

Large vision-language models (LVLMs) have significantly improved multimodal reasoning tasks, such as visual question answering and image captioning. These models embed multimodal facts within their parameters, rather than relying on…

Computation and Language · Computer Science 2025-02-18 Shengkang Wang , Hongzhan Lin , Ziyang Luo , Zhen Ye , Guang Chen , Jing Ma

Large Language Models (LLMs) have demonstrated remarkable capabilities on general text; however, their proficiency in specialized scientific domains that require deep, interconnected knowledge remains largely uncharacterized. Metabolomics…

Computation and Language · Computer Science 2025-10-17 Yuxing Lu , Xukai Zhao , J. Ben Tamo , Micky C. Nnamdi , Rui Peng , Shuang Zeng , Xingyu Hu , Jinzhuo Wang , May D. Wang

The potential of Large Language Model (LLM) as agents has been widely acknowledged recently. Thus, there is an urgent need to quantitatively \textit{evaluate LLMs as agents} on challenging tasks in interactive environments. We present…

The integration of Artificial Intelligence (AI), especially Large Language Models (LLMs), into the clinical diagnosis process offers significant potential to improve the efficiency and accessibility of medical care. While LLMs have shown…

Computation and Language · Computer Science 2024-10-15 Mingyu Derek Ma , Chenchen Ye , Yu Yan , Xiaoxuan Wang , Peipei Ping , Timothy S Chang , Wei Wang

Multimodal large language models (LLMs) are increasingly used to generate dermatology diagnostic narratives directly from images. However, reliable evaluation remains the primary bottleneck for responsible clinical deployment. We introduce…

Computer Vision and Pattern Recognition · Computer Science 2026-01-13 Yuhao Shen , Jiahe Qian , Shuping Zhang , Zhangtianyi Chen , Tao Lu , Juexiao Zhou

The deployment of Large Language Models (LLMs) in high-stakes clinical settings demands rigorous and reliable evaluation. However, existing medical benchmarks remain static, suffering from two critical limitations: (1) data contamination,…

Artificial Intelligence · Computer Science 2026-02-12 Zhiling Yan , Dingjie Song , Zhe Fang , Yisheng Ji , Xiang Li , Quanzheng Li , Lichao Sun

Large Language Models (LLMs) hold significant potential for advancing fact-checking by leveraging their capabilities in reasoning, evidence retrieval, and explanation generation. However, existing benchmarks fail to comprehensively evaluate…

Computation and Language · Computer Science 2025-06-17 Shuo Yang , Yuqin Dai , Guoqing Wang , Xinran Zheng , Jinfeng Xu , Jinze Li , Zhenzhe Ying , Weiqiang Wang , Edith C. H. Ngai

Large Language Models (LLMs) have demonstrated impressive capabilities across various specialist domains and have been integrated into high-stakes areas such as medicine. However, as existing medical-related benchmarks rarely stress-test…

Computation and Language · Computer Science 2026-03-26 Lin Yang , Yuancheng Yang , Xu Wang , Changkun Liu , Haihua Yang
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