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In contrast to their remarkable performance on general knowledge QA, the true abilities of Large Language Models (LLMs) in tasks demanding deep, specialized reasoning, such as in protein biology, have yet to be thoroughly investigated.…

Quantitative Methods · Quantitative Biology 2025-12-30 Dingyi Rong , Zijian Chen , Qi Jia , Kaiwei Zhang , Haotian Lu , Guangtao Zhai , Ning Liu

Multimodal large language models (MLLMs) have shown great potential in perception and interpretation tasks, but their capabilities in predictive reasoning remain under-explored. To address this gap, we introduce a novel benchmark that…

Computer Vision and Pattern Recognition · Computer Science 2023-10-23 Mingwei Zhu , Leigang Sha , Yu Shu , Kangjia Zhao , Tiancheng Zhao , Jianwei Yin

Recent advances in Large Language Models (LLMs) have shown promising results in complex reasoning tasks. However, current evaluations predominantly focus on single-turn reasoning scenarios, leaving interactive tasks largely unexplored. We…

Computation and Language · Computer Science 2026-05-22 Xiaoyuan Li , Keqin Bao , Yubo Ma , Moxin Li , Wenjie Wang , Rui Men , Yichang Zhang , Fuli Feng , Dayiheng Liu

Large language models (LLMs) have sparked growing interest in machine learning research agents that can autonomously propose ideas and conduct experiments. However, existing benchmarks predominantly adopt an engineering-oriented…

Computation and Language · Computer Science 2026-02-26 Qiran Zou , Hou Hei Lam , Wenhao Zhao , Yiming Tang , Tingting Chen , Samson Yu , Tianyi Zhang , Chang Liu , Xiangyang Ji , Dianbo Liu

Predicting cancer treatment outcomes requires models that are both accurate and interpretable, particularly in the presence of heterogeneous clinical data. While large language models (LLMs) have shown strong performance in biomedical NLP,…

Computation and Language · Computer Science 2025-10-21 Raghu Vamshi Hemadri , Geetha Krishna Guruju , Kristi Topollai , Anna Ewa Choromanska

While Large Language Models (LLMs) excel on standardized medical exams, high scores often fail to translate to high-quality responses for real-world medical queries. Current evaluations rely heavily on multiple-choice questions, failing to…

Recent advancements in multimodal large language models (MLLMs) have aimed to integrate and interpret data across diverse modalities. However, the capacity of these models to concurrently process and reason about multiple modalities remains…

Mathematical reasoning is a hallmark of human intelligence, and whether large language models (LLMs) can meaningfully perform it remains a central question in artificial intelligence and cognitive science. As LLMs are increasingly…

Computation and Language · Computer Science 2026-04-03 Linyang He , Qiyao Yu , Hanze Dong , Baohao Liao , Xinxing Xu , Micah Goldblum , Jiang Bian , Nima Mesgarani

Building robots that can perceive, reason, and act in dynamic, unstructured environments remains a core challenge. Recent embodied systems often adopt a dual-system paradigm, where System 2 handles high-level reasoning while System 1…

Recent advances in Multi-Modal Large Language Models (MLLMs) have enabled unified processing of language, vision, and structured inputs, opening the door to complex tasks such as logical deduction, spatial reasoning, and scientific…

Artificial Intelligence · Computer Science 2025-07-03 Guiyao Tie , Xueyang Zhou , Tianhe Gu , Ruihang Zhang , Chaoran Hu , Sizhe Zhang , Mengqu Sun , Yan Zhang , Pan Zhou , Lichao Sun

LMMs have shown impressive visual understanding capabilities, with the potential to be applied in agents, which demand strong reasoning and planning abilities. Nevertheless, existing benchmarks mostly assess their reasoning abilities in…

Computer Vision and Pattern Recognition · Computer Science 2024-12-09 Miaosen Zhang , Qi Dai , Yifan Yang , Jianmin Bao , Dongdong Chen , Kai Qiu , Chong Luo , Xin Geng , Baining Guo

Large vision-language models (LVLMs) have made substantial advances in reasoning tasks at the Olympiad level. Nevertheless, current Olympiad-level multimodal reasoning benchmarks for these models often emphasize single-image analysis and…

Computer Vision and Pattern Recognition · Computer Science 2026-04-23 Qiguang Chen , Chengyu Luan , Jiajun Wu , Qiming Yu , Yi Yang , Yizhuo Li , Jingqi Tong , Xiachong Feng , Libo Qin , Wanxiang Che

Large language models (LLMs) are increasingly envisioned as decision-support tools in clinical practice, yet safe clinical reasoning demands integrating heterogeneous knowledge bases -- trials, primary studies, regulatory documents, and…

Computation and Language · Computer Science 2025-05-22 Shan Chen , Pedro Moreira , Yuxin Xiao , Sam Schmidgall , Jeremy Warner , Hugo Aerts , Thomas Hartvigsen , Jack Gallifant , Danielle S. Bitterman

The comprehension of text-rich visual scenes has become a focal point for evaluating Multi-modal Large Language Models (MLLMs) due to their widespread applications. Current benchmarks tailored to the scenario emphasize perceptual…

Computer Vision and Pattern Recognition · Computer Science 2024-10-16 Bin Shan , Xiang Fei , Wei Shi , An-Lan Wang , Guozhi Tang , Lei Liao , Jingqun Tang , Xiang Bai , Can Huang

While large language models (LLMs) hold transformative potential for medicine, their reasoning robustness and safety in real-world clinical scenarios remain critically underexplored, particularly in dentistry. Here we introduce…

The adoption of large language models (LLMs) to assist clinicians has attracted remarkable attention. Existing works mainly adopt the close-ended question-answering (QA) task with answer options for evaluation. However, many clinical…

Multimodal clinical reasoning in the field of gastrointestinal (GI) oncology necessitates the integrated interpretation of endoscopic imagery, radiological data, and biochemical markers. Despite the evident potential exhibited by Multimodal…

Long-term memory (LTM) is essential for large language models (LLMs) to achieve autonomous intelligence in complex, evolving environments. Despite increasing efforts in memory-augmented and retrieval-based architectures, there remains a…

Computation and Language · Computer Science 2025-06-17 Luanbo Wan , Weizhi Ma

Large language models (LLMs) have shown emerging potential in spatiotemporal reasoning, making them promising candidates for building urban agents that support diverse urban downstream applications. Despite these benefits, existing studies…

Artificial Intelligence · Computer Science 2025-05-26 Siqi Lai , Yansong Ning , Zirui Yuan , Zhixi Chen , Hao Liu

The advent of large language models (LLMs) has unlocked great opportunities in complex data management tasks, particularly in question answering (QA) over complicated multi-table relational data. Despite significant progress, systematically…

Artificial Intelligence · Computer Science 2024-12-02 Zipeng Qiu , You Peng , Guangxin He , Binhang Yuan , Chen Wang