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Traditional drug design faces significant challenges due to inherent chemical and biological complexities, often resulting in high failure rates in clinical trials. Deep learning advancements, particularly generative models, offer potential…

Quantitative Methods · Quantitative Biology 2025-08-27 Mahsa Sheikholeslami , Navid Mazrouei , Yousof Gheisari , Afshin Fasihi , Matin Irajpour , Ali Motahharynia

Decoder-only Transformer models such as GPT have demonstrated exceptional performance in text generation, by autoregressively predicting the next token. However, the efficacy of running GPT on current hardware systems is bounded by low…

Hardware Architecture · Computer Science 2024-04-16 Yuting Wu , Ziyu Wang , Wei D. Lu

A typical optimization of customized accelerators for error-tolerant applications such as multimedia, recognition, and classification is to replace traditional arithmetic units like multipliers and adders with the approximate ones to…

Hardware Architecture · Computer Science 2024-07-17 Qing Zhang , Cheng Liu , Siting Liu , Yajuan Hui , Huawei Li , Xiaowei Li

Prefix-tuning, or more generally continuous prompt tuning, has become an essential paradigm of parameter-efficient transfer learning. Using a large pre-trained language model (PLM), prefix-tuning can obtain strong performance by training…

Computation and Language · Computer Science 2022-10-27 Yifan Chen , Devamanyu Hazarika , Mahdi Namazifar , Yang Liu , Di Jin , Dilek Hakkani-Tur

Artificial Intelligence Generated Content(AIGC), known for its superior visual results, represents a promising mitigation method for high-cost advertising applications. Numerous approaches have been developed to manipulate generated content…

Artificial Intelligence · Computer Science 2024-05-30 Shusong Xu , Peiye Liu

Autoregressive and Masked Transformers are incredibly effective as generative models and classifiers. While these models are most prevalent in NLP, they also exhibit strong performance in other domains, such as vision. This work contributes…

Machine Learning · Computer Science 2023-12-12 Manbir S Gulati , Paul F Roysdon

In a controllable text generation dataset, there exist unannotated attributes that could provide irrelevant learning signals to models that use it for training and thus degrade their performance. We propose focused prefix tuning(FPT) to…

Computation and Language · Computer Science 2023-06-13 Congda Ma , Tianyu Zhao , Makoto Shing , Kei Sawada , Manabu Okumura

As generative technologies advance, visual content has evolved into a complex mix of natural and AI-generated images, driving the need for more efficient coding techniques that prioritize perceptual quality. Traditional codecs and learned…

Computer Vision and Pattern Recognition · Computer Science 2025-09-18 Jianhui Chang

Text-to-image diffusion models (DMs) develop at an unprecedented pace, supported by thorough theoretical exploration and empirical analysis. Unfortunately, the discrepancy between DMs and autoregressive models (ARMs) complicates the path…

Computer Vision and Pattern Recognition · Computer Science 2025-02-28 Shitong Shao , Zikai Zhou , Tian Ye , Lichen Bai , Zhiqiang Xu , Zeke Xie

Diffusion models dominate image editing, yet their global denoising mechanism entangles edited regions with surrounding context, causing modifications to propagate into areas that should remain intact. We propose a fundamentally different…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Wei Chow , Linfeng Li , Xian Sun , Lingdong Kong , Zefeng Li , Qi Xu , Hang Song , Tian Ye , Xian Wang , Jinbin Bai , Shilin Xu , Xiangtai Li , Junting Pan , Shaoteng Liu , Ran Zhou , Tianshu Yang , Songhua Liu

We introduce MeshGPT, a new approach for generating triangle meshes that reflects the compactness typical of artist-created meshes, in contrast to dense triangle meshes extracted by iso-surfacing methods from neural fields. Inspired by…

Computer Vision and Pattern Recognition · Computer Science 2023-11-28 Yawar Siddiqui , Antonio Alliegro , Alexey Artemov , Tatiana Tommasi , Daniele Sirigatti , Vladislav Rosov , Angela Dai , Matthias Nießner

Across a wide range of hardware scenarios, the computational efficiency and physical size of the arithmetic units significantly influence the speed and footprint of the overall hardware system. Nevertheless, the effectiveness of prior…

Machine Learning · Computer Science 2024-05-14 Yao Lai , Jinxin Liu , David Z. Pan , Ping Luo

Topology optimization enables the design of highly efficient and complex structures, but conventional iterative methods, such as SIMP-based approaches, often suffer from high computational costs and sensitivity to initial conditions.…

Computational Engineering, Finance, and Science · Computer Science 2025-09-18 Aaron Lutheran , Srijan Das , Alireza Tabarraei

Learning time-series representations for discriminative tasks, such as classification and regression, has been a long-standing challenge in the healthcare domain. Current pre-training methods are limited in either unidirectional next-token…

Artificial Intelligence · Computer Science 2024-08-27 Ziyang Song , Qincheng Lu , He Zhu , David Buckeridge , Yue Li

Attribute-based Controlled Text Generation (CTG) refers to generating sentences that satisfy desirable attributes (e.g., emotions and topics). Existing works often utilize fine-tuning or resort to extra attribute classifiers, yet suffer…

Computation and Language · Computer Science 2022-04-29 Kexin Yang , Dayiheng Liu , Wenqiang Lei , Baosong Yang , Mingfeng Xue , Boxing Chen , Jun Xie

Adaptive regularization methods pre-multiply a descent direction by a preconditioning matrix. Due to the large number of parameters of machine learning problems, full-matrix preconditioning methods are prohibitively expensive. We show how…

Machine Learning · Computer Science 2020-11-19 Naman Agarwal , Brian Bullins , Xinyi Chen , Elad Hazan , Karan Singh , Cyril Zhang , Yi Zhang

Topology optimization for large scale problems continues to be a computational challenge. Several works exist in the literature to address this topic, and all make use of iterative solvers to handle the linear system arising from the Finite…

Numerical Analysis · Mathematics 2020-10-21 Darin Peetz , Ahmed Elbanna

ChatGPT has achieved remarkable success in natural language understanding. Considering that recommendation is indeed a conversation between users and the system with items as words, which has similar underlying pattern with ChatGPT, we…

Information Retrieval · Computer Science 2024-04-16 Yabin Zhang , Wenhui Yu , Erhan Zhang , Xu Chen , Lantao Hu , Peng Jiang , Kun Gai

Causal decoder-only transformer models used for generative language modelling, such as Generative Pre-trained Transformers (GPT), are trained to predict the next token in a sequence based only on its previous tokens. Despite this simple…

Computation and Language · Computer Science 2024-10-25 Nicholas Walker

Generating novel active molecules for a given protein is an extremely challenging task for generative models that requires an understanding of the complex physical interactions between the molecule and its environment. In this paper, we…