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Generative models have recently advanced $\textit{de novo}$ protein design by learning the statistical regularities of natural structures. However, current approaches face three key limitations: (1) Existing methods cannot jointly learn…

Machine Learning · Computer Science 2026-03-09 Zhanghan Ni , Yanjing Li , Zeju Qiu , Bernhard Schölkopf , Hongyu Guo , Weiyang Liu , Shengchao Liu

Pretraining has become a standard technique in computer vision and natural language processing, which usually helps to improve performance substantially. Previously, the most dominant pretraining method is transfer learning (TL), which uses…

Computer Vision and Pattern Recognition · Computer Science 2020-07-09 Xingyi Yang , Xuehai He , Yuxiao Liang , Yue Yang , Shanghang Zhang , Pengtao Xie

Semi-supervised learning holds great promise for many real-world applications, due to its ability to leverage both unlabeled and expensive labeled data. However, most semi-supervised learning algorithms still heavily rely on the limited…

Machine Learning · Computer Science 2023-12-29 Huiling Qin , Xianyuan Zhan , Yuanxun Li , Yu Zheng

High-level programming languages such as Python are increasingly used to provide intuitive interfaces to libraries written in lower-level languages and for assembling applications from various components. This migration towards…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-05-21 Yadu Babuji , Anna Woodard , Zhuozhao Li , Daniel S. Katz , Ben Clifford , Rohan Kumar , Lukasz Lacinski , Ryan Chard , Justin M. Wozniak , Ian Foster , Michael Wilde , Kyle Chard

Recent advances in multi-modal Large Language Models (M-LLMs) have demonstrated a powerful ability to synthesize implicit information from disparate sources, including images and text. These resourceful data from social media also introduce…

Cryptography and Security · Computer Science 2025-11-11 Junhao Li , Jiahao Chen , Zhou Feng , Chunyi Zhou

Automating experimental protocol design and execution remains as a fundamental bottleneck in realizing self-driving laboratories. We introduce PRISM (Protocol Refinement through Intelligent Simulation Modeling), a framework that automates…

Table learning, which lies at the intersection of machine learning and modern database systems, has recently attracted growing attention. However, existing table learning frameworks typically require explicit data export and extensive…

Databases · Computer Science 2026-02-13 Feiyang Chen , Ken Zhong , Aoqian Zhang , Zheng Wang , Li Pan , Jianhua Li

Norm-conserving pseudopotentials are used by a significant number of electronic-structure packages, but the practical differences among codes in the handling of the associated data hinder their interoperability and make it difficult to…

Computational Physics · Physics 2020-06-02 Alberto García , Matthieu Verstraete , Yann Pouillon , Javier Junquera

Motivation: The ability to perform operations on encrypted data has a growing number of applications in bioinformatics, with implications for data privacy in health care and biosecurity. The SEAL library is a popular implementation of fully…

Quantitative Methods · Quantitative Biology 2018-03-07 Alexander J. Titus , Shashwat Kishore , Todd Stavish , Stephanie M. Rogers , Karl Ni

PiML (read $\pi$-ML, /`pai`em`el/) is an integrated and open-access Python toolbox for interpretable machine learning model development and model diagnostics. It is designed with machine learning workflows in both low-code and high-code…

Machine Learning · Computer Science 2023-12-21 Agus Sudjianto , Aijun Zhang , Zebin Yang , Yu Su , Ningzhou Zeng

Medical image analysis suffers from a shortage of data, whether annotated or not. This becomes even more pronounced when it comes to 3D medical images. Self-Supervised Learning (SSL) can partially ease this situation by using unlabeled…

Computer Vision and Pattern Recognition · Computer Science 2024-07-08 Fei Gao , Siwen Wang , Fandong Zhang , Hong-Yu Zhou , Yizhou Wang , Churan Wang , Gang Yu , Yizhou Yu

The success of self-supervised learning (SSL) has mostly been attributed to the availability of unlabeled yet large-scale datasets. However, in a specialized domain such as medical imaging which is a lot different from natural images, the…

Computer Vision and Pattern Recognition · Computer Science 2023-06-30 Soumitri Chattopadhyay , Soham Ganguly , Sreejit Chaudhury , Sayan Nag , Samiran Chattopadhyay

Machine learning has become a crucial part of our lives, with applications spanning nearly every aspect of our daily activities. However, using personal information in machine learning applications has sparked significant security and…

Cryptography and Security · Computer Science 2025-10-14 Nges Brian Njungle , Eric Jahns , Luigi Mastromauro , Edwin P. Kayang , Milan Stojkov , Michel A. Kinsy

Language-guided supervision, which utilizes a frozen semantic target from a Pretrained Language Model (PLM), has emerged as a promising paradigm for visual Continual Learning (CL). However, relying on a single target introduces two critical…

Computer Vision and Pattern Recognition · Computer Science 2025-09-22 Xiwei Liu , Yulong Li , Yichen Li , Xinlin Zhuang , Haolin Yang , Huifa Li , Imran Razzak

Pre-training has been proven to be effective in boosting the performance of Isolated Sign Language Recognition (ISLR). Existing pre-training methods solely focus on the compact pose data, which eliminates background perturbation but…

Computer Vision and Pattern Recognition · Computer Science 2025-03-24 Kepeng Wu , Zecheng Li , Hezhen Hu , Wengang Zhou , Houqiang Li

Robotic imitation learning typically requires models that capture multimodal action distributions while operating at real-time control rates and accommodating multiple sensing modalities. Although recent generative approaches such as…

Robotics · Computer Science 2026-02-03 Amisha Bhaskar , Pratap Tokekar , Stefano Di Cairano , Alexander Schperberg

Self-Supervised Learning (SSL) models rely on a pretext task to learn representations. Because this pretext task differs from the downstream tasks used to evaluate the performance of these models, there is an inherent misalignment or…

Machine Learning · Computer Science 2023-04-12 Florian Bordes , Samuel Lavoie , Randall Balestriero , Nicolas Ballas , Pascal Vincent

While fine-tuning pre-trained networks has become a popular way to train image segmentation models, such backbone networks for image segmentation are frequently pre-trained using image classification source datasets, e.g., ImageNet. Though…

Computer Vision and Pattern Recognition · Computer Science 2022-07-08 Xuhong Li , Haoyi Xiong , Yi Liu , Dingfu Zhou , Zeyu Chen , Yaqing Wang , Dejing Dou

Self-supervised learning (SSL) opens up huge opportunities for medical image analysis that is well known for its lack of annotations. However, aggregating massive (unlabeled) 3D medical images like computerized tomography (CT) remains…

Computer Vision and Pattern Recognition · Computer Science 2022-08-17 Yutong Xie , Jianpeng Zhang , Yong Xia , Qi Wu

Joint speech-language training is challenging due to the large demand for training data and GPU consumption, as well as the modality gap between speech and language. We present ComSL, a speech-language model built atop a composite…

Computation and Language · Computer Science 2023-10-17 Chenyang Le , Yao Qian , Long Zhou , Shujie Liu , Yanmin Qian , Michael Zeng , Xuedong Huang