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In this paper, we propose a novel two-component loss for biomedical image segmentation tasks called the Instance-wise and Center-of-Instance (ICI) loss, a loss function that addresses the instance imbalance problem commonly encountered when…

Image and Video Processing · Electrical Eng. & Systems 2023-04-14 Muhammad Febrian Rachmadi , Charissa Poon , Henrik Skibbe

Deep convolutional neural networks (CNN) have proven to be remarkably effective in semantic segmentation tasks. Most popular loss functions were introduced targeting improved volumetric scores, such as the Dice coefficient (DSC). By design,…

Instance-sensitive losses for semantic segmentation such as blob loss and CC loss were designed to address instance imbalance, ensuring small lesions generate the same gradient as large ones, but operate only on single-class segmentation.…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Soumya Snigdha Kundu , Florian Kofler , Marina Ivory , Hendrik Moller , Jonathan Shapey , Tom Vercauteren

We propose a generalized focal loss function based on the Tversky index to address the issue of data imbalance in medical image segmentation. Compared to the commonly used Dice loss, our loss function achieves a better trade off between…

Computer Vision and Pattern Recognition · Computer Science 2018-10-19 Nabila Abraham , Naimul Mefraz Khan

Automatic segmentation methods are an important advancement in medical image analysis. Machine learning techniques, and deep neural networks in particular, are the state-of-the-art for most medical image segmentation tasks. Issues with…

Image and Video Processing · Electrical Eng. & Systems 2021-11-25 Michael Yeung , Evis Sala , Carola-Bibiane Schönlieb , Leonardo Rundo

Today, deep convolutional neural networks (CNNs) have demonstrated state-of-the-art performance for medical image segmentation, on various imaging modalities and tasks. Despite early success, segmentation networks may still generate…

Image and Video Processing · Electrical Eng. & Systems 2022-01-13 Rosana El Jurdi , Caroline Petitjean , Veronika Cheplygina , Paul Honeine , Fahed Abdallah

Accurate brain image segmentation, particularly for distinguishing various tissues from magnetic resonance imaging (MRI) images, plays a pivotal role in finding the neurological dis ease and medical image computing. In deep learning…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Hanuman Verma , Akshansh Gupta , Pranabesh Maji , Saurav Mandal , Vijay Kumar Pandey

The Dice similarity coefficient (DSC) is both a widely used metric and loss function for biomedical image segmentation due to its robustness to class imbalance. However, it is well known that the DSC loss is poorly calibrated, resulting in…

Image and Video Processing · Electrical Eng. & Systems 2022-11-02 Michael Yeung , Leonardo Rundo , Yang Nan , Evis Sala , Carola-Bibiane Schönlieb , Guang Yang

Although numerous improvements have been made in the field of image segmentation using convolutional neural networks, the majority of these improvements rely on training with larger datasets, model architecture modifications, novel loss…

Computer Vision and Pattern Recognition · Computer Science 2019-07-11 Saied Asgari Taghanaki , Kumar Abhishek , Ghassan Hamarneh

The accuracy of deep learning methods for two foundational tasks in medical image analysis -- detection and segmentation -- can suffer from class imbalance. We propose a `switching loss' function that adaptively shifts the emphasis between…

Image and Video Processing · Electrical Eng. & Systems 2020-08-11 Deepak Anand , Gaurav Patel , Yaman Dang , Amit Sethi

Brain lesion and anatomy segmentation in magnetic resonance images are fundamental tasks in neuroimaging research and clinical practice. Given enough training data, convolutional neuronal networks (CNN) proved to outperform all existent…

Computer Vision and Pattern Recognition · Computer Science 2019-04-16 Nicolas Roulet , Diego Fernandez Slezak , Enzo Ferrante

Traditional brain lesion segmentation models for multi-modal MRI are typically tailored to specific pathologies, relying on datasets with predefined modalities. Adapting to new MRI modalities or pathologies often requires training separate…

Image and Video Processing · Electrical Eng. & Systems 2025-07-25 Yousef Sadegheih , Pratibha Kumari , Dorit Merhof

Within medical imaging segmentation, the Dice coefficient and Hausdorff-based metrics are standard measures of success for deep learning models. However, modern loss functions for medical image segmentation often only consider the Dice…

Image and Video Processing · Electrical Eng. & Systems 2024-01-26 Adrian Celaya , Beatrice Riviere , David Fuentes

This paper explores the segmentation of very small medical objects with significant clinical value. While Convolutional Neural Networks (CNNs), particularly UNet-like models, and recent Transformers have shown substantial progress in image…

Image and Video Processing · Electrical Eng. & Systems 2024-06-27 Lingjie Kong , Qiaoling Wei , Chengming Xu , Han Chen , Yanwei Fu

The segmentation of skin lesions is a crucial task in clinical decision support systems for the computer aided diagnosis of skin lesions. Although deep learning-based approaches have improved segmentation performance, these models are often…

Image and Video Processing · Electrical Eng. & Systems 2021-02-23 Kumar Abhishek , Ghassan Hamarneh

Medical image segmentation has played an important role in medical analysis and widely developed for many clinical applications. Deep learning-based approaches have achieved high performance in semantic segmentation but they are limited to…

Image and Video Processing · Electrical Eng. & Systems 2020-12-07 Ngan Le , Trung Le , Kashu Yamazaki , Toan Duc Bui , Khoa Luu , Marios Savides

Deep neural networks have increased the accuracy of automatic segmentation, however, their accuracy depends on the availability of a large number of fully segmented images. Methods to train deep neural networks using images for which some,…

Brain lesion segmentation from multi-modal MRI often assumes fixed modality sets or predefined pathologies, making existing models difficult to adapt across cohorts and imaging protocols. Continual learning (CL) offers a natural solution…

Image and Video Processing · Electrical Eng. & Systems 2026-01-21 Yousef Sadegheih , Dorit Merhof , Pratibha Kumari

Accurate lesion-level segmentation on MRI is critical for multiple sclerosis (MS) diagnosis, prognosis, and disease monitoring. However, current evaluation practices largely rely on semantic segmentation post-processed with connected…

Image and Video Processing · Electrical Eng. & Systems 2025-05-29 Maxence Wynen , Pedro M. Gordaliza , Maxime Istasse , Anna Stölting , Pietro Maggi , Benoît Macq , Meritxell Bach Cuadra

Vascular segmentation in medical imaging plays a crucial role in analysing morphological and functional assessments. Traditional methods, like the centerline Dice (clDice) loss, ensure topology preservation but falter in capturing geometric…

Image and Video Processing · Electrical Eng. & Systems 2024-07-02 Pengcheng Shi , Jiesi Hu , Yanwu Yang , Zilve Gao , Wei Liu , Ting Ma
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