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In computational biophysics, where molecular data is expanding rapidly and system complexity is increasing exponentially, large language models (LLMs) and agent-based systems are fundamentally reshaping the field. This perspective article…

Large language models (LLM) exhibit broad utility but face limitations in quantum sensor development, stemming from interdisciplinary knowledge barriers and involving complex optimization processes. Here we present QCopilot, an LLM-based…

For a long time, humanity has pursued artificial intelligence (AI) equivalent to or surpassing the human level, with AI agents considered a promising vehicle for this pursuit. AI agents are artificial entities that sense their environment,…

The pace of scientific research, vital for improving human life, is complex, slow, and needs specialized expertise. Meanwhile, novel, impactful research often stems from both a deep understanding of prior work, and a cross-pollination of…

Computation and Language · Computer Science 2025-02-11 Jinheon Baek , Sujay Kumar Jauhar , Silviu Cucerzan , Sung Ju Hwang

Fully automated self-driving laboratories are promising to enable high-throughput and large-scale scientific discovery by reducing repetitive labour. However, effective automation requires deep integration of laboratory knowledge, which is…

Artificial Intelligence · Computer Science 2025-09-30 Shuxiang Cao , Zijian Zhang , Mohammed Alghadeer , Simone D Fasciati , Michele Piscitelli , Mustafa Bakr , Peter Leek , Alán Aspuru-Guzik

The emergence of large language models (LLMs) is propelling automated scientific discovery to the next level, with LLM-based Artificial Intelligence (AI) Scientist systems now taking the lead in scientific research. Several influential…

Artificial Intelligence · Computer Science 2025-08-04 Qiujie Xie , Yixuan Weng , Minjun Zhu , Fuchen Shen , Shulin Huang , Zhen Lin , Jiahui Zhou , Zilan Mao , Zijie Yang , Linyi Yang , Jian Wu , Yue Zhang

Large Language Models (LLMs) have emerged as powerful tools for accelerating scientific discovery, yet their static knowledge and hallucination issues hinder autonomous research applications. Recent advances integrate LLMs into agentic…

Artificial Intelligence · Computer Science 2025-12-23 Zeyu Xia , Jinzhe Ma , Congjie Zheng , Shufei Zhang , Yuqiang Li , Hang Su , P. Hu , Changshui Zhang , Xingao Gong , Wanli Ouyang , Lei Bai , Dongzhan Zhou , Mao Su

As AI promises to accelerate scientific discovery, it remains unclear whether fully AI-driven research is possible and whether it can adhere to key scientific values, such as transparency, traceability and verifiability. Mimicking human…

Other Quantitative Biology · Quantitative Biology 2024-04-30 Tal Ifargan , Lukas Hafner , Maor Kern , Ori Alcalay , Roy Kishony

The rapid advancement of scientific progress requires innovative tools that can accelerate knowledge discovery. Although recent AI methods, particularly large language models (LLMs), have shown promise in tasks such as hypothesis generation…

Artificial Intelligence · Computer Science 2025-05-28 Haoyang Su , Renqi Chen , Shixiang Tang , Zhenfei Yin , Xinzhe Zheng , Jinzhe Li , Biqing Qi , Qi Wu , Hui Li , Wanli Ouyang , Philip Torr , Bowen Zhou , Nanqing Dong

Recent advances in machine learning and AI, including Generative AI and LLMs, are disrupting technological innovation, product development, and society as a whole. AI's contribution to technology can come from multiple approaches that…

Artificial Intelligence (AI) has become essential in modern healthcare, with large language models (LLMs) offering promising advances in clinical decision-making. Traditional model-based approaches, including those leveraging in-context…

We report a case study of four end-to-end attempts to autonomously generate ML research papers using a pipeline of six LLM agents mapped to stages of the scientific workflow. Of these four, three attempts failed during implementation or…

Machine Learning · Computer Science 2026-01-08 Dhruv Trehan , Paras Chopra

Generative artificial intelligence (GenAI) can rapidly produce large and diverse volumes of content. This lends to it a quality of creativity which can be empowering in the early stages of design. In seeking to understand how creative ways…

Human-Computer Interaction · Computer Science 2024-03-20 Gionnieve Lim , Simon T. Perrault

The increasing availability of large-scale datasets has fueled rapid progress across many scientific fields, creating unprecedented opportunities for research and discovery while posing significant analytical challenges. Recent advances in…

Artificial Intelligence · Computer Science 2025-12-01 Erzhuo Shao , Yifang Wang , Yifan Qian , Zhenyu Pan , Han Liu , Dashun Wang

Computing has long served as a cornerstone of scientific discovery. Recently, a paradigm shift has emerged with the rise of large language models (LLMs), introducing autonomous systems, referred to as agents, that accelerate discovery…

AI research agents can now generate research ideas, design experiments, run code, and draft papers, raising the possibility of large-scale AI-assisted scientific discovery. Many current agent frameworks explicitly encourage the generation…

Computation and Language · Computer Science 2026-05-28 Yixuan Tang , Yi Yang

Quantum communication and quantum sensing, which leverage the unique characteristics of quantum systems, enable information-theoretically secure communication and high-precision measurement of physical quantities. However, they both face…

Quantum Physics · Physics 2025-11-13 Jiaxin Xu , Lechen Xu , Jingyang Liu , Huajian Ding , Qin Wang

The use of artificial intelligence (AI) in research across all disciplines is becoming ubiquitous. However, this ubiquity is largely driven by hyperspecific AI models developed during scientific studies for accomplishing a well-defined,…

Computers and Society · Computer Science 2023-12-19 Rishab Jain , Aditya Jain

Novel research ideas play a critical role in advancing scientific inquiries. Recent advancements in Large Language Models (LLMs) have demonstrated their potential to generate novel research ideas by leveraging large-scale scientific…

Artificial Intelligence · Computer Science 2025-11-05 Keyu Zhao , Weiquan Lin , Qirui Zheng , Fengli Xu , Yong Li

While LLMs have shown impressive capabilities in solving math or coding problems, the ability to make scientific discoveries remains a distinct challenge. This paper proposes a "Turing test for an AI scientist" to assess whether an AI agent…

Artificial Intelligence · Computer Science 2024-05-24 Xiaoxin Yin