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Although deep learning approaches have had tremendous success in image, video and audio processing, computer vision, and speech recognition, their applications to three-dimensional (3D) biomolecular structural data sets have been hindered…

Quantitative Methods · Quantitative Biology 2017-11-01 Zixuan Cang , Guo-Wei Wei

Recently, studies on machine learning have focused on methods that use symmetry implicit in a specific manifold as an inductive bias. Grassmann manifolds provide the ability to handle fundamental shapes represented as shape spaces, enabling…

Machine Learning · Computer Science 2023-12-06 Ryoma Yataka , Kazuki Hirashima , Masashi Shiraishi

Real world data often lie on low-dimensional Riemannian manifolds embedded in high-dimensional spaces. This motivates learning degenerate normalizing flows that map between the ambient space and a low-dimensional latent space. However, if…

Machine Learning · Computer Science 2026-04-14 Hanlin Yu , Søren Hauberg , Marcelo Hartmann , Arto Klami , Georgios Arvanitidis

Effectively modeling multimodal spatial omics data is critical for understanding tissue complexity and underlying biological mechanisms. While spatial transcriptomics, proteomics, and epigenomics capture molecular features, they lack…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Yongjun Xiao , Dian Meng , Xinlei Huang , Yanran Liu , Shiwei Ruan , Ziyue Qiao , Xubin Zheng

Graph diffusion models have made significant progress in learning structured graph data and have demonstrated strong potential for predictive tasks. Existing approaches typically embed node, edge, and graph-level features into a unified…

Machine Learning · Computer Science 2025-12-12 Yisen Gao , Xingcheng Fu , Qingyun Sun , Jianxin Li , Xianxian Li

Although deep learning has yielded impressive performance for face recognition, many studies have shown that different networks learn different feature maps: while some networks are more receptive to pose and illumination others appear to…

Computer Vision and Pattern Recognition · Computer Science 2017-02-16 Navaneeth Bodla , Jingxiao Zheng , Hongyu Xu , Jun-Cheng Chen , Carlos Castillo , Rama Chellappa

Cancer diagnosis, prognosis, and therapeutic response predictions are based on morphological information from histology slides and molecular profiles from genomic data. However, most deep learning-based objective outcome prediction and…

Computer Vision and Pattern Recognition · Computer Science 2020-09-04 Richard J. Chen , Ming Y. Lu , Jingwen Wang , Drew F. K. Williamson , Scott J. Rodig , Neal I. Lindeman , Faisal Mahmood

Euclidean representations distort data with intrinsic non-Euclidean structure. While Riemannian representation learning offers a solution by embedding data onto matching manifolds, it typically relies on an encoder to estimate densities on…

Machine Learning · Computer Science 2026-05-05 Andreas Bjerregaard , Søren Hauberg , Anders Krogh

Deep neural networks for 3D point cloud understanding have achieved remarkable success in object classification and recognition, yet recent work shows that these models remain highly vulnerable to adversarial perturbations. Existing 3D…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Gayathry Chandramana Krishnan Nampoothiry , Raghuram Venkatapuram , Anirban Ghosh , Ayan Dutta

Deep neural networks have become the main work horse for many tasks involving learning from data in a variety of applications in Science and Engineering. Traditionally, the input to these networks lie in a vector space and the operations…

Computer Vision and Pattern Recognition · Computer Science 2018-09-24 Rudrasis Chakraborty , Jose Bouza , Jonathan Manton , Baba C. Vemuri

Latent variable models are powerful tools for learning low-dimensional manifolds from high-dimensional data. However, when dealing with constrained data such as unit-norm vectors or symmetric positive-definite matrices, existing approaches…

Machine Learning · Computer Science 2025-03-10 Leonel Rozo , Miguel González-Duque , Noémie Jaquier , Søren Hauberg

Riemannian meta-optimization provides a promising approach to solving non-linear constrained optimization problems, which trains neural networks as optimizers to perform optimization on Riemannian manifolds. However, existing Riemannian…

Machine Learning · Computer Science 2025-02-07 Peilin Yu , Yuwei Wu , Zhi Gao , Xiaomeng Fan , Yunde Jia

Physics-informed neural networks (PINNs) effectively embed physical principles into machine learning, but often struggle with complex or alternating geometries. We propose a novel method for integrating geometric transformations within…

Machine Learning · Computer Science 2023-11-30 Samuel Burbulla

With the emergence of new photonic and plasmonic materials with optimized properties as well as advanced nanofabrication techniques, nanophotonic devices are now capable of providing solutions to global challenges in energy conversion,…

The Grassmann manifold of linear subspaces is important for the mathematical modelling of a multitude of applications, ranging from problems in machine learning, computer vision and image processing to low-rank matrix optimization problems,…

Numerical Analysis · Mathematics 2024-01-09 Thomas Bendokat , Ralf Zimmermann , P. -A. Absil

Multimodal data provide complementary information of a natural phenomenon by integrating data from various domains with very different statistical properties. Capturing the intra-modality and cross-modality information of multimodal data is…

Machine Learning · Computer Science 2021-11-29 Maysam Behmanesh , Peyman Adibi , Mohammad Saeed Ehsani , Jocelyn Chanussot

Although many machine learning algorithms involve learning subspaces with particular characteristics, optimizing a parameter matrix that is constrained to represent a subspace can be challenging. One solution is to use Riemannian…

Machine Learning · Computer Science 2017-03-10 Stephen Giguere , Francisco Garcia , Sridhar Mahadevan

Modern deep neural networks have shown remarkable performance in medical image classification. However, such networks either emphasize pixel-intensity features instead of fundamental anatomical structures (e.g., those encoded by topological…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Pengfei Gu , Huimin Li , Haoteng Tang , Dongkuan , Xu , Erik Enriquez , DongChul Kim , Bin Fu , Danny Z. Chen

In machine learning, data is usually represented in a (flat) Euclidean space where distances between points are along straight lines. Researchers have recently considered more exotic (non-Euclidean) Riemannian manifolds such as hyperbolic…

Machine Learning · Computer Science 2021-01-12 Marc T. Law , Jos Stam

Correlation matrices are fundamental summaries of functional brain networks, yet standard analyses often treat entries independently, ignoring the curved geometry of correlation space. Existing geometric methods frequently lack closed-form…

Machine Learning · Computer Science 2026-05-22 Mario Severino , Manuela Moretto , Robert A. McCutcheon , Mattia Veronese
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