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We conducted a reproducibility study on Integrated Gradients (IG) based methods and the Important Direction Gradient Integration (IDGI) framework. IDGI eliminates the explanation noise in each step of the computation of IG-based methods…
Multiple instance learning (MIL) has shown significant promise in histopathology whole slide image (WSI) analysis for cancer diagnosis and prognosis. However, the inherent spatial heterogeneity of WSIs presents critical challenges, as…
Treatment approaches for colorectal cancer (CRC) are highly dependent on the molecular subtype, as immunotherapy has shown efficacy in cases with microsatellite instability (MSI) but is ineffective for the microsatellite stable (MSS)…
Multiple instance learning (MIL) is the standard approach for whole-slide image (WSI) classification and survival prediction, where attention-based models ag gregate patch features into slide-level predictions. These models treat attention…
Multiple Instance Learning (MIL) for whole slide image (WSI) analysis in computational pathology often neglects instance-level learning as supervision is typically provided only at the bag level, hindering the integrated consideration of…
Post-hoc explanation methods, e.g., Grad-CAM, enable humans to inspect the spatial regions responsible for a particular network decision. However, it is shown that such explanations are not always consistent with human priors, such as…
The whole slide histopathology images (WSIs) play a critical role in gastric cancer diagnosis. However, due to the large scale of WSIs and various sizes of the abnormal area, how to select informative regions and analyze them are quite…
Whole Slide Image (WSI) classification has very significant applications in clinical pathology, e.g., tumor identification and cancer diagnosis. Currently, most research attention is focused on Multiple Instance Learning (MIL) using static…
The Composed Image Retrieval (CIR) task aims to retrieve target images using a composed query consisting of a reference image and a modified text. Advanced methods often utilize contrastive learning as the optimization objective, which…
We introduce Generalized Integrated Gradients (GIG), a formal extension of the Integrated Gradients (IG) (Sundararajan et al., 2017) method for attributing credit to the input variables of a predictive model. GIG improves IG by explaining a…
Domain shift in the field of histopathological imaging is a common phenomenon due to the intra- and inter-hospital variability of staining and digitization protocols. The implementation of robust models, capable of creating generalized…
With the development of computer-aided diagnosis (CAD) and image scanning technology, Whole-slide Image (WSI) scanners are widely used in the field of pathological diagnosis. Therefore, WSI analysis has become the key to modern digital…
Artificial Intelligence (AI) can potentially support histopathologists in the diagnosis of a broad spectrum of cancer types. In colorectal cancer (CRC), AI can alleviate the laborious task of characterization and reporting on resected…
Most tumor grading systems for human as for veterinary histopathology are based upon the absolute count of mitotic figures in a certain reference area of a histology slide. Since time for prognostication is limited in a diagnostic setting,…
Automatic delineation of organ-at-risk (OAR) and gross-tumor-volume (GTV) is of great significance for radiotherapy planning. However, it is a challenging task to learn powerful representations for accurate delineation under limited pixel…
Recently there have been many algorithms proposed for the classification of very high resolution whole slide images (WSIs). These new algorithms are mostly focused on finding novel ways to combine the information from small local patches…
Accurate segmentation of laryngo-pharyngeal tumors is crucial for precise diagnosis and effective treatment planning. However, traditional single-modality imaging methods often fall short of capturing the complex anatomical and pathological…
Multi-Instance Learning (MIL) has shown impressive performance for histopathology whole slide image (WSI) analysis using bags or pseudo-bags. It involves instance sampling, feature representation, and decision-making. However, existing…
Integrated Gradients has become a popular method for post-hoc model interpretability. De-spite its popularity, the composition and relative impact of different regions of the integral path are not well understood. We explore these effects…
Assessing microsatellite stability status of a patient's colorectal cancer is crucial in personalizing treatment regime. Recently, convolutional-neural-networks (CNN) combined with transfer-learning approaches were proposed to circumvent…