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We present two deep generative models based on Variational Autoencoders to improve the accuracy of drug response prediction. Our models, Perturbation Variational Autoencoder and its semi-supervised extension, Drug Response Variational…

Machine Learning · Statistics 2017-07-07 Ladislav Rampasek , Daniel Hidru , Petr Smirnov , Benjamin Haibe-Kains , Anna Goldenberg

The framework of variational autoencoders (VAEs) provides a principled method for jointly learning latent-variable models and corresponding inference models. However, the main drawback of this approach is the blurriness of the generated…

Machine Learning · Computer Science 2020-07-01 Ioannis Gatopoulos , Maarten Stol , Jakub M. Tomczak

Variational autoencoders (VAEs) face a notorious problem wherein the variational posterior often aligns closely with the prior, a phenomenon known as posterior collapse, which hinders the quality of representation learning. To mitigate this…

Machine Learning · Statistics 2023-10-25 Yuma Ichikawa , Koji Hukushima

Multimodal variational autoencoders (VAEs) aim to capture shared latent representations by integrating information from different data modalities. A significant challenge is accurately inferring representations from any subset of modalities…

Machine Learning · Computer Science 2024-10-16 Yuta Oshima , Masahiro Suzuki , Yutaka Matsuo

We take steps towards understanding the "posterior collapse (PC)" difficulty in variational autoencoders (VAEs),~i.e. a degenerate optimum in which the latent codes become independent of their corresponding inputs. We rely on calculus of…

Machine Learning · Computer Science 2019-08-01 Octavian-Eugen Ganea , Yashas Annadani , Gary Bécigneul

A novel framework for Bayesian structural model updating is presented in this study. The proposed method utilizes the surrogate unimodal encoders of a multimodal variational autoencoder (VAE). The method facilitates an approximation of the…

Machine Learning · Statistics 2024-06-21 Tatsuya Itoi , Kazuho Amishiki , Sangwon Lee , Taro Yaoyama

Variational Autoencoders (VAEs) are essential for large-scale audio tasks like diffusion-based generation. However, existing open-source models often neglect auditory perceptual aspects during training, leading to weaknesses in phase…

Sound · Computer Science 2025-11-07 Kangdi Wang , Zhiyue Wu , Dinghao Zhou , Rui Lin , Junyu Dai , Tao Jiang

Generative modeling of 3D brain MRIs presents difficulties in achieving high visual fidelity while ensuring sufficient coverage of the data distribution. In this work, we propose to address this challenge with composable, multiscale…

Image and Video Processing · Electrical Eng. & Systems 2023-01-12 Jaivardhan Kapoor , Jakob H. Macke , Christian F. Baumgartner

This paper proposes Dirichlet Variational Autoencoder (DirVAE) using a Dirichlet prior for a continuous latent variable that exhibits the characteristic of the categorical probabilities. To infer the parameters of DirVAE, we utilize the…

Machine Learning · Computer Science 2019-01-10 Weonyoung Joo , Wonsung Lee , Sungrae Park , Il-Chul Moon

We investigate the potential of adaptive blind equalizers based on variational inference for carrier recovery in optical communications. These equalizers are based on a low-complexity approximation of maximum likelihood channel estimation.…

Signal Processing · Electrical Eng. & Systems 2022-09-16 Vincent Lauinger , Fred Buchali , Laurent Schmalen

Deep generative models provide flexible frameworks for modeling complex, structured data such as images, videos, 3D objects, and texts. However, when applied to sequences of human skeletons, standard variational autoencoders (VAEs) often…

Computer Vision and Pattern Recognition · Computer Science 2026-05-18 Arafat Rahman , Shashwat Kumar , Laura E. Barnes , Anuj Srivastava

The vector quantization is a widely used method to map continuous representation to discrete space and has important application in tokenization for generative mode, bottlenecking information and many other tasks in machine learning. Vector…

Machine Learning · Computer Science 2024-10-15 Mingyuan Yan , Jiawei Wu , Rushi Shah , Dianbo Liu

This paper introduces a new interpretation of the Variational Autoencoder framework by taking a fully geometric point of view. We argue that vanilla VAE models unveil naturally a Riemannian structure in their latent space and that taking…

Machine Learning · Statistics 2022-11-04 Clément Chadebec , Stéphanie Allassonnière

Variational AutoEncoders (VAEs) are powerful generative models that merge elements from statistics and information theory with the flexibility offered by deep neural networks to efficiently solve the generation problem for high dimensional…

Machine Learning · Computer Science 2021-03-02 A. Asperti , D. Evangelista , E. Loli Piccolomini

We propose a novel Conditional Latent space Variational Autoencoder (CL-VAE) to perform improved pre-processing for anomaly detection on data with known inlier classes and unknown outlier classes. This proposed variational autoencoder (VAE)…

Machine Learning · Computer Science 2024-10-17 Oskar Åström , Alexandros Sopasakis

Physical imaging is a foundational characterization method in areas from condensed matter physics and chemistry to astronomy and spans length scales from atomic to universe. Images encapsulate crucial data regarding atomic bonding,…

The variational autoencoder (VAE) is a popular probabilistic generative model. However, one shortcoming of VAEs is that the latent variables cannot be discrete, which makes it difficult to generate data from different modes of a…

Machine Learning · Statistics 2017-11-21 Jay A. Hennig , Akash Umakantha , Ryan C. Williamson

In this paper, we study two aspects of the variational autoencoder (VAE): the prior distribution over the latent variables and its corresponding posterior. First, we decompose the learning of VAEs into layerwise density estimation, and…

Machine Learning · Computer Science 2017-10-09 Chin-Wei Huang , Ahmed Touati , Laurent Dinh , Michal Drozdzal , Mohammad Havaei , Laurent Charlin , Aaron Courville

Recommending appropriate tags to items can facilitate content organization, retrieval, consumption and other applications, where hybrid tag recommender systems have been utilized to integrate collaborative information and content…

Information Retrieval · Computer Science 2022-04-21 Jing Yi , Xubin Ren , Zhenzhong Chen

This paper reviews the novel concept of controllable variational autoencoder (ControlVAE), discusses its parameter tuning to meet application needs, derives its key analytic properties, and offers useful extensions and applications.…

Machine Learning · Computer Science 2020-11-04 Huajie Shao , Zhisheng Xiao , Shuochao Yao , Aston Zhang , Shengzhong Liu , Tarek Abdelzaher
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