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The ability to perform causal reasoning is widely considered a core feature of intelligence. In this work, we investigate whether large language models (LLMs) can coherently reason about causality. Much of the existing work in natural…

Estimating treatment effects (TE) from observational data is a critical yet complex task in many fields, from healthcare and economics to public policy. While recent advances in machine learning and causal inference have produced powerful…

Machine Learning · Computer Science 2025-08-15 Jeroen Berrevoets , Julianna Piskorz , Robert Davis , Harry Amad , Jim Weatherall , Mihaela van der Schaar

The field of healthcare has increasingly turned its focus towards Large Language Models (LLMs) due to their remarkable performance. However, their performance in actual clinical applications has been underexplored. Traditional evaluations…

While Large Language Models (LLMs) excel on standardized medical exams, high scores often fail to translate to high-quality responses for real-world medical queries. Current evaluations rely heavily on multiple-choice questions, failing to…

Behavioral simulation is increasingly used to anticipate responses to interventions. Large language models (LLMs) enable researchers to specify population characteristics and intervention context in natural language, but it remains unclear…

Computers and Society · Computer Science 2026-04-14 Zonghan Li , Feng Ji

MLLMs MLLMs are beginning to appear in clinical workflows, but their ability to perform complex medical reasoning remains unclear. We present Med-CMR, a fine-grained Medical Complex Multimodal Reasoning benchmark. Med-CMR distinguishes from…

In practical statistical causal discovery (SCD), embedding domain expert knowledge as constraints into the algorithm is important for reasonable causal models reflecting the broad knowledge of domain experts, despite the challenges in the…

Machine Learning · Computer Science 2025-05-13 Masayuki Takayama , Tadahisa Okuda , Thong Pham , Tatsuyoshi Ikenoue , Shingo Fukuma , Shohei Shimizu , Akiyoshi Sannai

The integration of Artificial Intelligence (AI), especially Large Language Models (LLMs), into the clinical diagnosis process offers significant potential to improve the efficiency and accessibility of medical care. While LLMs have shown…

Computation and Language · Computer Science 2024-10-15 Mingyu Derek Ma , Chenchen Ye , Yu Yan , Xiaoxuan Wang , Peipei Ping , Timothy S Chang , Wei Wang

Leveraging the synergy between causal knowledge graphs and a large language model (LLM), our study introduces a groundbreaking approach for computational hypothesis generation in psychology. We analyzed 43,312 psychology articles using a…

Artificial Intelligence · Computer Science 2024-08-19 Song Tong , Kai Mao , Zhen Huang , Yukun Zhao , Kaiping Peng

Medical image diagnosis is challenging because many diseases resemble normal anatomy and exhibit substantial interpatient variability. Clinicians routinely rely on comparative diagnosis, such as referencing cross-patient healthy control…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Ruinan Jin , Gexin Huang , Xinwei Shen , Qiong Zhang , Yan Shuo Tan , Xiaoxiao Li

Ensuring fairness in machine learning requires understanding how sensitive attributes like race or gender causally influence outcomes. Existing causal discovery (CD) methods often struggle to recover fairness-relevant pathways in the…

Machine Learning · Computer Science 2026-01-08 Khadija Zanna , Akane Sano

Large Language Models (LLMs) have demonstrated impressive capabilities in role-playing scenarios, particularly in simulating domain-specific experts using tailored prompts. This ability enables LLMs to adopt the persona of individuals with…

Artificial Intelligence · Computer Science 2025-01-14 Xinyao Ma , Rui Zhu , Zihao Wang , Jingwei Xiong , Qingyu Chen , Haixu Tang , L. Jean Camp , Lucila Ohno-Machado

Multimodal large language models (MLLMs) demonstrate considerable potential in clinical diagnostics, a domain that inherently requires synthesizing complex visual and textual data alongside consulting authoritative medical literature.…

Computation and Language · Computer Science 2026-03-23 Yannian Gu , Zhongzhen Huang , Linjie Mu , Xizhuo Zhang , Shaoting Zhang , Xiaofan Zhang

How does a cause lead to an effect, and which intermediate causal steps explain their connection? This work scrutinizes the mechanistic causal reasoning capabilities of large language models (LLMs) to answer these questions through the task…

Artificial Intelligence · Computer Science 2026-03-19 Liesbeth Allein , Nataly Pineda-Castañeda , Andrea Rocci , Marie-Francine Moens

Causal structure discovery from observations can be improved by integrating background knowledge provided by an expert to reduce the hypothesis space. Recently, Large Language Models (LLMs) have begun to be considered as sources of prior…

Machine Learning · Computer Science 2024-05-24 Victor-Alexandru Darvariu , Stephen Hailes , Mirco Musolesi

Code Large Language Models (CLLMs) have exhibited outstanding performance in program synthesis, attracting the focus of the research community. The evaluation of CLLM's program synthesis capability has generally relied on manually curated…

Software Engineering · Computer Science 2025-05-13 Longtian Wang , Tianlin Li , Xiaofei Xie , Yuhan Zhi , Jian Wang , Chao Shen

We propose DISC-MedLLM, a comprehensive solution that leverages Large Language Models (LLMs) to provide accurate and truthful medical response in end-to-end conversational healthcare services. To construct high-quality Supervised…

Computation and Language · Computer Science 2023-08-29 Zhijie Bao , Wei Chen , Shengze Xiao , Kuang Ren , Jiaao Wu , Cheng Zhong , Jiajie Peng , Xuanjing Huang , Zhongyu Wei

Faithful evaluation of language model capabilities is crucial for deriving actionable insights that can inform model development. However, rigorous causal evaluations in this domain face significant methodological challenges, including…

Machine Learning · Computer Science 2025-06-13 Jikai Jin , Vasilis Syrgkanis , Sham Kakade , Hanlin Zhang

Randomized controlled trials are a cornerstone of medicine and the social sciences as they enable reliable estimates of causal effects. However, they are costly and time-consuming to conduct, motivating interest in predicting causal effects…

Despite the success of Large Language Models (LLMs) across various fields, their potential to generate untruthful, biased and harmful responses poses significant risks, particularly in critical applications. This highlights the urgent need…

Artificial Intelligence · Computer Science 2025-05-27 Mengdi Zhang , Kai Kiat Goh , Peixin Zhang , Jun Sun , Rose Lin Xin , Hongyu Zhang
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