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While large language models (LLMs) achieve near-perfect scores on medical licensing exams, these evaluations inadequately reflect the complexity and diversity of real-world clinical practice. We introduce MedHELM, an extensible evaluation…

The discovery of causal relationships between random variables is an important yet challenging problem that has applications across many scientific domains. Differentiable causal discovery (DCD) methods are effective in uncovering causal…

Machine Learning · Computer Science 2024-10-29 Shiv Kampani , David Hidary , Constantijn van der Poel , Martin Ganahl , Brenda Miao

Large Language Models (LLMs) and multi-agent systems have shown impressive capabilities in natural language tasks but face challenges in clinical trial applications, primarily due to limited access to external knowledge. Recognizing the…

Computation and Language · Computer Science 2024-07-23 Ling Yue , Sixue Xing , Jintai Chen , Tianfan Fu

Large Language Models (LLMs) have demonstrated remarkable adaptability, showcasing their capacity to excel in tasks for which they were not explicitly trained. However, despite their impressive natural language processing (NLP)…

Computation and Language · Computer Science 2023-09-08 Supun Manathunga , Isuru Hettigoda

Clinical Decision Support Systems (CDSS) utilize evidence-based knowledge and patient data to offer real-time recommendations, with Large Language Models (LLMs) emerging as a promising tool to generate plain-text explanations for medical…

Computation and Language · Computer Science 2023-10-04 D. Umerenkov , G. Zubkova , A. Nesterov

Causal graph recovery is traditionally done using statistical estimation-based methods or based on individual's knowledge about variables of interests. They often suffer from data collection biases and limitations of individuals' knowledge.…

Computation and Language · Computer Science 2024-06-19 Yuzhe Zhang , Yipeng Zhang , Yidong Gan , Lina Yao , Chen Wang

Benchmarks establish a standardized evaluation framework to systematically assess the performance of large language models (LLMs), facilitating objective comparisons and driving advancements in the field. However, existing benchmarks fail…

Computation and Language · Computer Science 2026-02-16 Ziqian Zhang , Xingjian Hu , Yue Huang , Kai Zhang , Ruoxi Chen , Yixin Liu , Qingsong Wen , Kaidi Xu , Xiangliang Zhang , Neil Zhenqiang Gong , Lichao Sun

Causal discovery aims to identify causal relationships between variables and is a fundamental problem across the sciences. Traditional statistical causal discovery (SCD) methods rely solely on observational data and ignore the contextual…

Artificial Intelligence · Computer Science 2026-05-27 Hao Duong Le , Xin Xia , Haijie Xu , Chen Zhang

Mainstream methods for Legal Judgment Prediction (LJP) based on Pre-trained Language Models (PLMs) heavily rely on the statistical correlation between case facts and judgment results. This paradigm lacks explicit modeling of legal…

Computation and Language · Computer Science 2026-03-13 Yuzhi Liang , Lixiang Ma , Xinrong Zhu

This study evaluates causal reasoning in large language models (LLMs) using 99 clinically grounded laboratory test scenarios aligned with Pearl's Ladder of Causation: association, intervention, and counterfactual reasoning. We examined…

Artificial Intelligence · Computer Science 2025-09-23 Balu Bhasuran , Mattia Prosperi , Karim Hanna , John Petrilli , Caretia JeLayne Washington , Zhe He

Causal reasoning is a core component of intelligence. Large language models (LLMs) have shown impressive capabilities in generating human-like text, raising questions about whether their responses reflect true understanding or statistical…

Artificial Intelligence · Computer Science 2025-06-09 Hanna M. Dettki , Brenden M. Lake , Charley M. Wu , Bob Rehder

Genes, proteins and other biological entities influence one another via causal molecular networks. Causal relationships in such networks are mediated by complex and diverse mechanisms, through latent variables, and are often specific to…

Machine Learning · Computer Science 2025-03-07 Izzy Newsham , Luka Kovačević , Richard Moulange , Nan Rosemary Ke , Sach Mukherjee

The mismatch between the growing demand for psychological counseling and the limited availability of services has motivated research into the application of Large Language Models (LLMs) in this domain. Consequently, there is a need for a…

Computation and Language · Computer Science 2025-11-13 Bichen Wang , Yixin Sun , Junzhe Wang , Hao Yang , Xing Fu , Yanyan Zhao , Si Wei , Shijin Wang , Bing Qin

Causal discovery for both cross-sectional and temporal data has traditionally followed a dataset-specific paradigm, where a new model is fitted for each individual dataset. Such an approach limits the potential of multi-dataset pretraining.…

Large Vision-Language Models (LVLMs) achieve strong performance on visual question answering benchmarks, yet often rely on spurious correlations rather than genuine causal reasoning. Existing evaluations primarily assess the correctness of…

Artificial Intelligence · Computer Science 2026-02-25 Dhita Putri Pratama , Soyeon Caren Han , Yihao Ding

The rise of large language models (LLMs) has opened new opportunities in Recommender Systems (RSs) by enhancing user behavior modeling and content understanding. However, current approaches that integrate LLMs into RSs solely utilize either…

Information Retrieval · Computer Science 2024-03-26 Yunjia Xi , Weiwen Liu , Jianghao Lin , Chuhan Wu , Bo Chen , Ruiming Tang , Weinan Zhang , Yong Yu

Predicting cancer treatment outcomes requires models that are both accurate and interpretable, particularly in the presence of heterogeneous clinical data. While large language models (LLMs) have shown strong performance in biomedical NLP,…

Computation and Language · Computer Science 2025-10-21 Raghu Vamshi Hemadri , Geetha Krishna Guruju , Kristi Topollai , Anna Ewa Choromanska

Recent breakthroughs in artificial intelligence have driven a paradigm shift, where large language models (LLMs) with billions or trillions of parameters are trained on vast datasets, achieving unprecedented success across a series of…

Computation and Language · Computer Science 2024-10-22 Anpeng Wu , Kun Kuang , Minqin Zhu , Yingrong Wang , Yujia Zheng , Kairong Han , Baohong Li , Guangyi Chen , Fei Wu , Kun Zhang

Causal discovery (CD) plays a pivotal role in numerous scientific fields by clarifying the causal relationships that underlie phenomena observed in diverse disciplines. Despite significant advancements in CD algorithms that enhance bias and…

Machine Learning · Computer Science 2025-03-25 Khadija Zanna , Akane Sano

Causal reasoning capability is critical in advancing large language models (LLMs) toward strong artificial intelligence. While versatile LLMs appear to have demonstrated capabilities in understanding contextual causality and providing…

Artificial Intelligence · Computer Science 2025-06-30 Haoang Chi , He Li , Wenjing Yang , Feng Liu , Long Lan , Xiaoguang Ren , Tongliang Liu , Bo Han