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Research in oncology has changed the focus from histological properties of tumors in a specific organ to a specific genomic aberration potentially shared by multiple cancer types. This motivates the basket trial, which assesses the efficacy…

Applications · Statistics 2020-02-11 Jin Jin , Marie-Karelle Riviere , Xiaodong Luo , Yingwen Dong

The use of mathematical models to make predictions about tumor growth and response to treatment has become increasingly more prevalent in the clinical setting. The level of complexity within these models ranges broadly, and the calibration…

Quantitative Methods · Quantitative Biology 2021-12-28 Allison L. Lewis , Kathleen M. Storey , Heyrim Cho , Anna C. Zittle

Curating, processing, and combining large-scale medical imaging datasets from national studies is a non-trivial task due to the intense computation and data throughput required, variability of acquired data, and associated financial…

The rapid development of diagnostic technologies in healthcare is leading to higher requirements for physicians to handle and integrate the heterogeneous, yet complementary data that are produced during routine practice. For instance, the…

Machine Learning · Computer Science 2023-01-30 Can Cui , Haichun Yang , Yaohong Wang , Shilin Zhao , Zuhayr Asad , Lori A. Coburn , Keith T. Wilson , Bennett A. Landman , Yuankai Huo

Lately, software development has become a predominantly online process, as more teams host and monitor their projects remotely. Sophisticated approaches employ issue tracking systems like Jira, predicting the time required to resolve issues…

Software Engineering · Computer Science 2026-01-16 Dimitrios-Nikitas Nastos , Themistoklis Diamantopoulos , Davide Tosi , Martina Tropeano , Andreas L. Symeonidis

Clinical Practice Guidelines (CPGs) for cancer diseases evolve rapidly due to new evidence generated by active research. Currently, CPGs are primarily published in a document format that is ill-suited for managing this developing knowledge.…

Artificial Intelligence · Computer Science 2023-07-21 Pralaypati Ta , Bhumika Gupta , Arihant Jain , Sneha Sree C , Arunima Sarkar , Keerthi Ram , Mohanasankar Sivaprakasam

With the advancement in the technology sector spanning over every field, a huge influx of information is inevitable. Among all the opportunities that the advancements in the technology have brought, one of them is to propose efficient…

Information Retrieval · Computer Science 2021-12-14 Sudhanshu , Narinder Singh Punn , Sanjay Kumar Sonbhadra , Sonali Agarwal

Computational pathology is part of precision oncology medicine. The integration of high-throughput data including genomics, transcriptomics, proteomics, metabolomics, pathomics, and radiomics into clinical practice improves cancer treatment…

Image and Video Processing · Electrical Eng. & Systems 2022-06-07 Liangrui Pan , Zhichao Feng , Shaoliang Peng

Software development projects management is a complex endeavor because it requires dealing with numerous unforeseen events that constantly arise along the way and that go against the expectations that had been established at the beginning.…

Software Engineering · Computer Science 2022-09-27 Fernando Pinciroli

Cancer subtyping plays a crucial role in informing prognosis and guiding personalized treatment strategies. However, conventional subtyping approaches often rely on static, biopsy-derived scores that hardly capture the biological…

Methodology · Statistics 2026-03-12 Lara Cavinato , Marco Rocchi , Luca Viganò , Francesca Ieva

A schema-guided approach to dialogue management has been shown in recent work to be effective in creating robust customizable virtual agents capable of acting as friendly peers or task assistants. However, successful applications of these…

Artificial Intelligence · Computer Science 2022-07-18 Benjamin Kane , Catherine Giugno , Lenhart Schubert , Kurtis Haut , Caleb Wohn , Ehsan Hoque

Much has changed since the inaugural ICGSE conference in 2006. Tools have improved, awareness of cultural differences is widespread, and developments such as the foregrounding of open source have all enhanced our ability to work across…

Software Engineering · Computer Science 2021-04-07 James Herbsleb

The process of engineering and deploying applications in the edge/embedded space is massively complicated by the non-homogeneous nature of the software stack and the complexity of diagnostics & debugging. Often different languages and…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-05-15 Anthony Arnold , Mark Marron

Collaboration is crucial in Software Engineering (SE), yet factors like gender bias can shape team dynamics and behaviours. This study examines an eight-week project involving 39 SE students across eight teams contributing to GitHub…

Software Engineering · Computer Science 2025-02-21 Rita Garcia , Christoph Treude

Quantifying the uncertainty in predictive models is critical for establishing trust and enabling risk-informed decision making for personalized medicine. In contrast to one-size-fits-all approaches that seek to mitigate risk at the…

Computational Engineering, Finance, and Science · Computer Science 2025-05-15 Graham Pash , Umberto Villa , David A. Hormuth , Thomas E. Yankeelov , Karen Willcox

Software analytics is a data-driven approach to decision making, which allows software practitioners to leverage valuable insights from data about software to achieve higher development process productivity and improve different aspects of…

Software Engineering · Computer Science 2022-01-12 Duarte Oliveira , João Fidalgo , Joelma Choma , Eduardo Guerra , Filipe Correia

Using natural language processing tools, we investigate the differences of recommendations in medical guidelines for the same decision problem -- breast cancer screening. We show that these differences arise from knowledge brought to the…

Information Retrieval · Computer Science 2020-07-22 Hossein Hematialam , Luciana Garbayo , Seethalakshmi Gopalakrishnan , Wlodek Zadrozny

The proliferation of sensor technologies and advancements in data collection methods have enabled the accumulation of very large amounts of data. Increasingly, these datasets are considered for scientific research. However, the design of…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-07-28 Fatemeh Rouzbeh , Ananth Grama , Paul Griffin , Mohammad Adibuzzaman

Late diagnosis and high costs are key factors that negatively impact the care of cancer patients worldwide. Although the availability of biological markers for the diagnosis of cancer type is increasing, costs and reliability of tests…

Machine Learning · Computer Science 2019-08-20 Sterling Ramroach , Melford John , Ajay Joshi

Software engineering increasingly involves making high-stakes decisions under uncertainty, using signals from code, field data, and socio-technical processes. Recent AI-driven support (e.g., anomaly detection, predictive analytics, AIOps,…

Software Engineering · Computer Science 2026-05-05 Roberto Pietrantuono , Luca Giamattei , Stefano Russo , Julien Siebert , Neil Walkinshaw
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