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Document images are often degraded by various stains, significantly impacting their readability and hindering downstream applications such as document digitization and analysis. The absence of a comprehensive stained document dataset has…

Computer Vision and Pattern Recognition · Computer Science 2024-10-31 Mingxian Li , Hao Sun , Yingtie Lei , Xiaofeng Zhang , Yihang Dong , Yilin Zhou , Zimeng Li , Xuhang Chen

In pathology, tissue samples are assessed using multiple staining techniques to enhance contrast in unique histologic features. In this paper, we introduce a multimodal CNN-GNN based graph fusion approach that leverages complementary…

Image and Video Processing · Electrical Eng. & Systems 2022-04-28 Chaitanya Dwivedi , Shima Nofallah , Maryam Pouryahya , Janani Iyer , Kenneth Leidal , Chuhan Chung , Timothy Watkins , Andrew Billin , Robert Myers , John Abel , Ali Behrooz

Virtual staining is a promising technique that uses deep generative models to recreate histological stains, providing a faster and more cost-effective alternative to traditional tissue chemical staining. Specifically for H&E-HER2 staining…

Image and Video Processing · Electrical Eng. & Systems 2025-10-02 Pascal Klöckner , José Teixeira , Diana Montezuma , Jaime S. Cardoso , Hugo M. Horlings , Sara P. Oliveira

Recent advances in multi-modal AI have demonstrated promising potential for generating the currently expensive spatial transcriptomics (ST) data directly from routine histology images, offering a means to reduce the high cost and…

Computer Vision and Pattern Recognition · Computer Science 2025-08-21 Junchao Zhu , Ruining Deng , Junlin Guo , Tianyuan Yao , Juming Xiong , Chongyu Qu , Mengmeng Yin , Yu Wang , Shilin Zhao , Haichun Yang , Daguang Xu , Yucheng Tang , Yuankai Huo

Double staining in histopathology, particularly for metaplastic breast cancer, typically employs H&E and P63 dyes. However, P63's tissue damage and high cost necessitate alternative methods. This study introduces xAI-CycleGAN, an advanced…

Image and Video Processing · Electrical Eng. & Systems 2023-12-07 Tibor Sloboda , Lukáš Hudec , Wanda Benešová

"Is it possible to predict expression levels of different genes at a given spatial location in the routine histology image of a tumor section by modeling its stain absorption characteristics?" In this work, we propose a "stain-aware"…

Image and Video Processing · Electrical Eng. & Systems 2021-08-27 Muhammad Dawood , Kim Branson , Nasir M. Rajpoot , Fayyaz ul Amir Afsar Minhas

Time-resolved angiography with interleaved stochastic trajectories (TWIST) has been widely used for dynamic contrast enhanced MRI (DCE-MRI). To achieve highly accelerated acquisitions, TWIST combines the periphery of the k-space data from…

Computer Vision and Pattern Recognition · Computer Science 2018-06-12 Eunju Cha , Eung Yeop Kim , Jong Chul Ye

Pathological features are the gold standard for tumor diagnosis, guiding treatment and prognosis. However, standard histopathological process is labor-intensive and time-consuming, while frozen sections have lower accuracy. Dynamic…

Virtual staining has emerged as a powerful alternative to traditional histopathological staining techniques, enabling rapid, reagent-free image transformations. However, existing evaluation methods predominantly rely on full-reference image…

Image and Video Processing · Electrical Eng. & Systems 2025-07-18 Qiankai Wang , James E. D. Tweel , Parsin Haji Reza , Anita Layton

Performance of deep learning algorithms decreases drastically if the data distributions of the training and testing sets are different. Due to variations in staining protocols, reagent brands, and habits of technicians, color variation in…

Computer Vision and Pattern Recognition · Computer Science 2020-12-01 Abhijeet Patil , Mohd. Talha , Aniket Bhatia , Nikhil Cherian Kurian , Sammed Mangale , Sunil Patel , Amit Sethi

Conventional video object segmentation (VOS) methods usually necessitate a substantial volume of pixel-level annotated video data for fully supervised learning. In this paper, we present HVC, a \textbf{h}ybrid static-dynamic \textbf{v}isual…

Computer Vision and Pattern Recognition · Computer Science 2024-04-23 Gensheng Pei , Yazhou Yao , Jianbo Jiao , Wenguan Wang , Liqiang Nie , Jinhui Tang

Establishing visual correspondences under large intra-class variations requires analyzing images at different levels, from features linked to semantics and context to local patterns, while being invariant to instance-specific details. To…

Computer Vision and Pattern Recognition · Computer Science 2019-08-20 Juhong Min , Jongmin Lee , Jean Ponce , Minsu Cho

Spatial transcriptomics offers spatially resolved gene expression profiling within tissue sections, but its cost and limited throughput hinder large-scale deployment. To extend this capability to routine practice, recent computational…

Machine Learning · Computer Science 2026-05-07 Keunho Byeon , Jin Tae Kwak

The analysis of the tumor environment on digital histopathology slides is becoming key for the understanding of the immune response against cancer, supporting the development of novel immuno-therapies. We introduce here a novel deep…

Image and Video Processing · Electrical Eng. & Systems 2019-06-27 Ansh Kapil , Tobias Wiestler , Simon Lanzmich , Abraham Silva , Keith Steele , Marlon Rebelatto , Guenter Schmidt , Nicolas Brieu

Microscopy enables direct observation of cellular morphology in 3D, with transmitted-light methods offering low-cost, minimally invasive imaging and fluorescence microscopy providing specificity and contrast. Virtual staining combines these…

Printed and digitally displayed photos have the ability to hide imperceptible digital data that can be accessed through internet-connected imaging systems. Another way to think about this is physical photographs that have unique QR codes…

Computer Vision and Pattern Recognition · Computer Science 2020-03-27 Matthew Tancik , Ben Mildenhall , Ren Ng

Prediction of Kelvin-Helmholtz instability (KHI) is crucial across various fields, requiring extensive high-fidelity data. However, experimental data are often sparse and noisy, while simulated data may lack credibility due to discrepancies…

Fluid Dynamics · Physics 2024-11-13 Jiahao Wu , Yuxin Wu , Xin Li , Guihua Zhang

Subsurface stratigraphy contains important spatio-temporal information about accumulation, deformation, and layer formation in polar ice sheets. In particular, variations in internal ice layer thickness provide valuable constraints for snow…

Machine Learning · Computer Science 2026-04-14 Zesheng Liu , Maryam Rahnemoonfar

Histopathological staining of human tissue is essential for disease diagnosis. Recent advances in virtual tissue staining technologies using artificial intelligence (AI) alleviate some of the costly and tedious steps involved in traditional…

Image and Video Processing · Electrical Eng. & Systems 2025-06-17 Luzhe Huang , Yuzhu Li , Nir Pillar , Tal Keidar Haran , William Dean Wallace , Aydogan Ozcan

Conditional generative adversarial networks (cGANs) have enabled high-fidelity computational staining and destaining of hematoxylin and eosin (H&E) in digital pathology whole-slide images (WSI). However, their ability to generalize to…

Computer Vision and Pattern Recognition · Computer Science 2026-05-15 Aarushi Kulkarni , Alarice Lowe , Pratik Shah