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We develop topological methods for analyzing difference topology experiments involving 3-string tangles. Difference topology is a novel technique used to unveil the structure of stable protein-DNA complexes involving two or more DNA…

Geometric Topology · Mathematics 2016-01-20 Isabel K. Darcy , John Luecke , Mariel Vazquez

Functional networks provide a topological description of activity patterns in the brain, as they stem from the propagation of neural activity on the underlying anatomical or structural network of synaptic connections. This latter is well…

Disordered Systems and Neural Networks · Physics 2021-02-11 Ali Safari , Paolo Moretti , Ibai Diez , Jesus M. Cortes , Miguel Ángel Muñoz

The permutation test is an often used test procedure in brain imaging. Unfortunately, generating every possible permutation for large-scale brain image datasets such as HCP and ADNI with hundreds images is not practical. Many previous…

Computation · Statistics 2019-04-10 Moo K. Chung , Yixian Wang , Shih-Gu Huang , Ilwoo Lyu

Recently, persistent homology has had tremendous success in biomolecular data analysis. It works by examining the topological relationship or connectivity of a group of atoms in a molecule at a variety of scales, then rendering a family of…

Biomolecules · Quantitative Biology 2019-03-27 David Bramer , Guo-Wei Wei

Brain networks has attracted the interests of many neuroscientists. From functional MRI (fMRI) data, statistical tools have been developed to recover brain networks. However, the dimensionality of whole-brain fMRI, usually in hundreds of…

Methodology · Statistics 2014-04-08 Xi Luo

Understanding neurological disorder is a fundamental problem in neuroscience, which often requires the analysis of brain networks derived from functional magnetic resonance imaging (fMRI) data. Despite the prevalence of Graph Neural…

Machine Learning · Computer Science 2024-09-18 Jiaxing Xu , Kai He , Mengcheng Lan , Qingtian Bian , Wei Li , Tieying Li , Yiping Ke , Miao Qiao

Childhood maltreatment may adversely affect brain development and consequently influence behavioral, emotional, and psychological patterns during adulthood. In this study, we propose an analytical pipeline for modeling the altered…

Neurons and Cognition · Quantitative Biology 2023-11-16 Moo K. Chung , Tahmineh Azizi , Jamie L. Hanson , Andrew L. Alexander , Richard J. Davidson , Seth D. Pollak

Spatial transcriptomics studies are becoming increasingly large and commonplace, necessitating simultaneous analysis of a large number of spatially resolved variables. Correspondingly, a diverse range of methodologies have been proposed to…

Quantitative Methods · Quantitative Biology 2025-09-09 James Boyle , Gregory Hamm , Eleanor Williams , Robin JG Hartman , Magnus Soderburg , Ian Henry , Michael Casey

With the emergence of dynamic multiplex networks, corresponding to graphs where multiple types of edges evolve over time, a key inferential task is to determine whether the layers associated with different edge types differ in their…

Methodology · Statistics 2025-12-04 Maximilian Baum , Francesco Sanna Passino , Axel Gandy

Heterophilic Graph Neural Networks (HGNNs) have shown promising results for semi-supervised learning tasks on graphs. Notably, most real-world heterophilic graphs are composed of a mixture of nodes with different neighbor patterns,…

Machine Learning · Computer Science 2025-02-26 Jinluan Yang , Zhengyu Chen , Teng Xiao , Wenqiao Zhang , Yong Lin , Kun Kuang

We study the behavior of fermion spectral functions for the holographic topological Weyl and nodal line semimetals. We calculate the topological invariants from the Green functions of both holographic semimetals using the topological…

High Energy Physics - Theory · Physics 2018-12-19 Yan Liu , Ya-Wen Sun

Graph (or network) is a mathematical structure that has been widely used to model relational data. As real-world systems get more complex, multilayer (or multiple) networks are employed to represent diverse patterns of relationships among…

Methodology · Statistics 2024-06-10 Mingao Yuan , Qianqian Yao

Topological transforms are parametrized families of topological invariants, which, by analogy with transforms in signal processing, are much more discriminative than single measurements. The first two topological transforms to be defined…

Algebraic Topology · Mathematics 2020-04-01 Clément Maria , Steve Oudot , Elchanan Solomon

It has been observed that representations learned by distinct neural networks conceal structural similarities when the models are trained under similar inductive biases. From a geometric perspective, identifying the classes of…

Machine Learning · Computer Science 2024-03-21 Irene Cannistraci , Luca Moschella , Marco Fumero , Valentino Maiorca , Emanuele Rodolà

We propose a method, based on persistent homology, to uncover topological properties of a priori unknown covariates of neuron activity. Our input data consist of spike train measurements of a set of neurons of interest, a candidate list of…

Neurons and Cognition · Quantitative Biology 2015-10-23 Gard Spreemann , Benjamin Dunn , Magnus Bakke Botnan , Nils A. Baas

Understanding the structure of the brain, and how it changes with time and disease, is a core goal of structural neuroimaging. Contemporary approaches to structural brain analysis are dominated by voxel-wise, mass-univariate methods such as…

Algebraic Topology · Mathematics 2026-04-28 Donato Quiccione , Mariam Pirashvili , Nathan Broomhead , Sean J. Fallon

We develop a general analytical and numerical framework for estimating intra- and extra-neurite water fractions and diffusion coefficients, as well as neurite orientational dispersion, in each imaging voxel. By employing a set of rotational…

Biological Physics · Physics 2018-04-10 Dmitry S. Novikov , Jelle Veraart , Ileana O. Jelescu , Els Fieremans

Topological neural networks (TNNs) are information processing architectures that model representations from data lying over topological spaces (e.g., simplicial or cell complexes) and allow for decentralized implementation through localized…

Information Theory · Computer Science 2025-02-17 Simone Fiorellino , Claudio Battiloro , Paolo Di Lorenzo

Solving the intricate quantum behavior of interacting particles is key to unlocking the mysteries of condensed matter, but capturing their complex correlations across different scales remains a monumental challenge. We introduce a neural…

Calculation of topological invariants for crystalline systems is well understood in reciprocal space, allowing for the topological classification of a wide spectrum of materials. In this work, we present a new technique based on the…

Disordered Systems and Neural Networks · Physics 2022-02-28 Alejandro José Uría-Álvarez , Daniel Molpeceres-Mingo , Juan José Palacios