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The healthcare sector has experienced a rapid accumulation of digital data recently, especially in the form of electronic health records (EHRs). EHRs constitute a precious resource that IS researchers could utilize for clinical applications…

Machine Learning · Computer Science 2024-11-06 Thiti Suttaket , L Vivek Harsha Vardhan , Stanley Kok

Electronic Health Records (EHR)-based disease prediction models have demonstrated significant clinical value in promoting precision medicine and enabling early intervention. However, existing large language models face two major challenges:…

Computation and Language · Computer Science 2025-06-19 Junke Wang , Hongshun Ling , Li Zhang , Longqian Zhang , Fang Wang , Yuan Gao , Zhi Li

With the rising global burden of chronic diseases and the multimodal and heterogeneous clinical data (medical imaging, free-text recordings, wearable sensor streams, etc.), there is an urgent need for a unified multimodal AI framework that…

Artificial Intelligence · Computer Science 2025-09-24 Dingxin Lu , Shurui Wu , Xinyi Huang

Clinical notes are often stored in unstructured or semi-structured formats after extraction from electronic medical record (EMR) systems, which complicates their use for secondary analysis and downstream clinical applications. Reliable…

Computation and Language · Computer Science 2025-12-30 Risha Surana , Adrian Law , Sunwoo Kim , Rishab Sridhar , Angxiao Han , Peiyu Hong

Recent advancements in artificial intelligence (AI), especially large language models (LLMs), have significantly advanced healthcare applications and demonstrated potentials in intelligent medical treatment. However, there are conspicuous…

Computation and Language · Computer Science 2025-05-26 Qinkai Yu , Mingyu Jin , Dong Shu , Chong Zhang , Lizhou Fan , Wenyue Hua , Suiyuan Zhu , Yanda Meng , Zhenting Wang , Mengnan Du , Yongfeng Zhang

Retrieval-Augmented Large Language Models (LLMs), which integrate external knowledge, have shown remarkable performance in medical domains, including clinical diagnosis. However, existing RAG methods often struggle to tailor retrieval…

Computation and Language · Computer Science 2025-10-16 Jiawei He , Mingyi Jia , Zhihao Jia , Junwen Duan , Yan Song , Jianxin Wang

Existing depression screening predominantly relies on standardized questionnaires (e.g., PHQ-9, BDI), which suffer from high misdiagnosis rates (18-34% in clinical studies) due to their static, symptom-counting nature and susceptibility to…

Neurons and Cognition · Quantitative Biology 2025-04-24 Zhenguang Zhong , Zhixuan Wang

The integration of Artificial Intelligence (AI), especially Large Language Models (LLMs), into the clinical diagnosis process offers significant potential to improve the efficiency and accessibility of medical care. While LLMs have shown…

Computation and Language · Computer Science 2024-10-15 Mingyu Derek Ma , Chenchen Ye , Yu Yan , Xiaoxuan Wang , Peipei Ping , Timothy S Chang , Wei Wang

One way to extract patterns from clinical records is to consider each patient record as a bag with various number of instances in the form of symptoms. Medical diagnosis is to discover informative ones first and then map them to one or more…

Machine Learning · Computer Science 2019-04-10 Zeyuan Wang , Josiah Poon , Shiding Sun , Simon Poon

Neural network representation learning frameworks have recently shown to be highly effective at a wide range of tasks ranging from radiography interpretation via data-driven diagnostics to clinical decision support. This often superior…

Information Retrieval · Computer Science 2018-11-14 Xing Wei , Carsten Eickhoff

Automatic ICD coding from clinical text is a critical task in medical NLP but remains hindered by the extreme long-tail distribution of diagnostic codes. Thousands of rare and zero-shot ICD codes are severely underrepresented in datasets…

Computation and Language · Computer Science 2025-11-19 Truong Vo , Weiyi Wu , Kaize Ding

Reference labels for machine-learning benchmarks are increasingly synthesized with LLM assistance, but their reliability remains underexamined. We audit MedCalc-Bench, a clinical benchmark for medical score computation whose labels were…

Artificial Intelligence · Computer Science 2026-04-14 Junze Ye , Daniel Tawfik , Alex J. Goodell , Nikhil V. Kotha , Mark K. Buyyounouski , Mohsen Bayati

Electronic health records (EHRs) are long, noisy, and often redundant, posing a major challenge for the clinicians who must navigate them. Large language models (LLMs) offer a promising solution for extracting and reasoning over this…

Computation and Language · Computer Science 2025-08-21 Skatje Myers , Dmitriy Dligach , Timothy A. Miller , Samantha Barr , Yanjun Gao , Matthew Churpek , Anoop Mayampurath , Majid Afshar

Electronic Health Records (EHRs) have been heavily used to predict various downstream clinical tasks such as readmission or mortality. One of the modalities in EHRs, clinical notes, has not been fully explored for these tasks due to its…

Computation and Language · Computer Science 2019-06-05 Bonggun Shin , Julien Hogan , Andrew B. Adams , Raymond J. Lynch , Rachel E. Patzer , Jinho D. Choi

Leveraging knowledge from electronic health records (EHRs) to predict a patient's condition is essential to the effective delivery of appropriate care. Clinical notes of patient EHRs contain valuable information from healthcare…

Computation and Language · Computer Science 2023-05-18 Nayeon Kim , Yinhua Piao , Sun Kim

Clinical reasoning agents based on large language models (LLMs) aim to automate tasks such as intensive care unit (ICU) monitoring and patient state tracking from electronic health records (EHRs). Existing systems typically rely on manually…

Artificial Intelligence · Computer Science 2026-05-12 Timothy Ossowski , Xinchi Liu , Danyal Maqbool , Vaibhav Dhanuka , Sheng Zhang , Hoifung Poon , Majid Afshar , Tyler Bradshaw , Junjie Hu

With their growing capabilities, generative large language models (LLMs) are being increasingly investigated for complex medical tasks. However, their effectiveness in real-world clinical applications remains underexplored. To address this,…

Computation and Language · Computer Science 2026-01-27 Paul Grundmann , Dennis Fast , Jan Frick , Thomas Steffek , Felix Gers , Wolfgang Nejdl , Alexander Löser

Early detection of preventable diseases is important for better disease management, improved inter-ventions, and more efficient health-care resource allocation. Various machine learning approacheshave been developed to utilize information…

Machine Learning · Computer Science 2018-08-16 Jingshu Liu , Zachariah Zhang , Narges Razavian

Predicting diagnoses from Electronic Health Records (EHRs) is an important medical application of multi-label learning. We propose a convolutional residual model for multi-label classification from doctor notes in EHR data. A given patient…

Machine Learning · Statistics 2018-08-10 Xinyuan Zhang , Ricardo Henao , Zhe Gan , Yitong Li , Lawrence Carin

Electronic health records contain inconsistently structured or free-text data, requiring efficient preprocessing to enable predictive health care models. Although artificial intelligence-driven natural language processing tools show promise…