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In the field of computational pathology, deep learning algorithms have made significant progress in tasks such as nuclei segmentation and classification. However, the potential of these advanced methods is limited by the lack of available…

Computer Vision and Pattern Recognition · Computer Science 2024-07-22 Hyun-Jic Oh , Won-Ki Jeong

Osteoclast cell image analysis plays a key role in osteoporosis research, but it typically involves extensive manual image processing and hand annotations by a trained expert. In the last few years, a handful of machine learning approaches…

Computer Vision and Pattern Recognition · Computer Science 2024-04-17 Sai Kumar Reddy Manne , Brendan Martin , Tyler Roy , Ryan Neilson , Rebecca Peters , Meghana Chillara , Christine W. Lary , Katherine J. Motyl , Michael Wan

Nuclei instance segmentation is an essential task in pathology image analysis, serving as the foundation for many downstream applications. The release of several public datasets has significantly advanced research in this area, yet many…

Image and Video Processing · Electrical Eng. & Systems 2025-08-22 Jiamu Wang , Jin Tae Kwak

Nuclei appear small in size, yet, in real clinical practice, the global spatial information and correlation of the color or brightness contrast between nuclei and background, have been considered a crucial component for accurate nuclei…

Image and Video Processing · Electrical Eng. & Systems 2023-07-18 Zhenqi He , Mathias Unberath , Jing Ke , Yiqing Shen

Accurate and robust segmentation of lung cancers from CT, even those located close to mediastinum, is needed to more accurately plan and deliver radiotherapy and to measure treatment response. Therefore, we developed a new cross-modality…

Image and Video Processing · Electrical Eng. & Systems 2021-12-08 Jue Jiang , Andreas Rimner , Joseph O. Deasy , Harini Veeraraghavan

In computational pathology, automatic nuclei instance segmentation plays an essential role in whole slide image analysis. While many computerized approaches have been proposed for this task, supervised deep learning (DL) methods have shown…

Image and Video Processing · Electrical Eng. & Systems 2023-08-04 Amirreza Mahbod , Christine Polak , Katharina Feldmann , Rumsha Khan , Katharina Gelles , Georg Dorffner , Ramona Woitek , Sepideh Hatamikia , Isabella Ellinger

The visual-question localized-answering (VQLA) system can serve as a knowledgeable assistant in surgical education. Except for providing text-based answers, the VQLA system can highlight the interested region for better surgical scene…

Computer Vision and Pattern Recognition · Computer Science 2023-07-25 Long Bai , Mobarakol Islam , Hongliang Ren

Instance segmentation and classification of nuclei is an important task in computational pathology. We show that StarDist, a deep learning nuclei segmentation method originally developed for fluorescence microscopy, can be extended and…

Computer Vision and Pattern Recognition · Computer Science 2022-08-22 Martin Weigert , Uwe Schmidt

Automated semantic segmentation of cell nuclei in microscopic images is crucial for disease diagnosis and tissue microenvironment analysis. Nonetheless, this task presents challenges due to the complexity and heterogeneity of cells. While…

Image and Video Processing · Electrical Eng. & Systems 2023-08-10 Zhuchen Shao , Sourya Sengupta , Hua Li , Mark A. Anastasio

Deep learning for medical imaging is hampered by task-specific models that lack generalizability and prognostic capabilities, while existing 'universal' approaches suffer from simplistic conditioning and poor medical semantic understanding.…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Numan Saeed , Tausifa Jan Saleem , Fadillah Maani , Muhammad Ridzuan , Hu Wang , Mohammad Yaqub

Automatic tissue segmentation and nuclei detection is an important task in pathology, aiding in biomarker extraction and discovery. The panoptic segmentation of nuclei and tissue in advanced melanoma (PUMA) challenge aims to improve tissue…

Computer Vision and Pattern Recognition · Computer Science 2025-03-18 Negar Shahamiri , Moritz Rempe , Lukas Heine , Jens Kleesiek , Fabian Hörst

We demonstrate that in knowledge distillation for diffusion models, the teacher network's highly complex denoising process - stemming from its substantially larger capacity - poses a significant challenge for the student model to faithfully…

Computer Vision and Pattern Recognition · Computer Science 2026-05-28 Hyunsoo Han , Sangyeop Yeo , Jaejun Yoo

Cellular nuclei recognition serves as a fundamental and essential step in the workflow of digital pathology. However, with disparate source organs and staining procedures among histology image clusters, the scanned tiles inherently conform…

Quantitative Methods · Quantitative Biology 2024-07-22 Jianan Fan , Dongnan Liu , Canran Li , Hang Chang , Heng Huang , Filip Braet , Mei Chen , Weidong Cai

In sequence to sequence learning, the self-attention mechanism proves to be highly effective, and achieves significant improvements in many tasks. However, the self-attention mechanism is not without its own flaws. Although self-attention…

Computation and Language · Computer Science 2019-11-22 Guangxiang Zhao , Xu Sun , Jingjing Xu , Zhiyuan Zhang , Liangchen Luo

Treatment approaches for colorectal cancer (CRC) are highly dependent on the molecular subtype, as immunotherapy has shown efficacy in cases with microsatellite instability (MSI) but is ineffective for the microsatellite stable (MSS)…

Computer Vision and Pattern Recognition · Computer Science 2024-11-13 Hadar Hezi , Matan Gelber , Alexander Balabanov , Yosef E. Maruvka , Moti Freiman

Accurate and efficient cell nuclei detection and classification in histopathological Whole Slide Images (WSIs) are pivotal for digital pathology applications. Traditional cell segmentation approaches, while commonly used, are…

Computer Vision and Pattern Recognition · Computer Science 2025-02-11 Oscar Pina , Eduard Dorca , Verónica Vilaplana

In histopathological image analysis, feature extraction for classification is a challenging task due to the diversity of histology features suitable for each problem as well as presence of rich geometrical structures. In this paper, we…

Computer Vision and Pattern Recognition · Computer Science 2016-03-30 Tiep Huu Vu , Hojjat Seyed Mousavi , Vishal Monga , Arvind UK Rao , Ganesh Rao

The recent rapid and tremendous success of deep convolutional neural networks (CNN) on many challenging computer vision tasks largely derives from the accessibility of the well-annotated ImageNet and PASCAL VOC datasets. Nevertheless,…

Computer Vision and Pattern Recognition · Computer Science 2017-12-29 Xiaosong Wang , Le Lu , Hoo-chang Shin , Lauren Kim , Mohammadhadi Bagheri , Isabella Nogues , Jianhua Yao , Ronald M. Summers

Lung cancer is the leading cause of patient mortality in the world. Early diagnosis of malignant pulmonary nodules in CT images can have a significant impact on reducing disease mortality and morbidity. In this work, we propose LMLCC-Net, a…

Image and Video Processing · Electrical Eng. & Systems 2025-11-27 Tasnia Binte Mamun , Adhora Madhuri , Nusaiba Sobir , Taufiq Hasan

Accurately and quickly binuclear cell (BC) detection plays a significant role in predicting the risk of leukemia and other malignant tumors. However, manual microscopy counting is time-consuming and lacks objectivity. Moreover, with the…

Computer Vision and Pattern Recognition · Computer Science 2022-08-29 Baomin Wang , Geng Hu , Dan Chen , Lihua Hu , Cheng Li , Yu An , Guiping Hu , Guang Jia