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Disease heterogeneity has been a critical challenge for precision diagnosis and treatment, especially in neurologic and neuropsychiatric diseases. Many diseases can display multiple distinct brain phenotypes across individuals, potentially…

Medical multi-modal pre-training has revealed promise in computer-aided diagnosis by leveraging large-scale unlabeled datasets. However, existing methods based on masked autoencoders mainly rely on data-level reconstruction tasks, but lack…

Computer Vision and Pattern Recognition · Computer Science 2024-04-10 Yupei Zhang , Li Pan , Qiushi Yang , Tan Li , Zhen Chen

Effectively leveraging multimodal data such as various images, laboratory tests and clinical information is gaining traction in a variety of AI-based medical diagnosis and prognosis tasks. Most existing multi-modal techniques only focus on…

Image and Video Processing · Electrical Eng. & Systems 2023-11-28 Yingying Fang , Shuang Wu , Sheng Zhang , Chaoyan Huang , Tieyong Zeng , Xiaodan Xing , Simon Walsh , Guang Yang

In the current age, human lifestyle has become more knowledge oriented leading to generation of sedentary employment. This has given rise to a number of health and mental disorders. Mental wellness is one of the most neglected but crucial…

Machine Learning · Computer Science 2023-06-19 Rahee Walambe , Pranav Nayak , Ashmit Bhardwaj , Ketan Kotecha

Missing modalities pose a major issue in Alzheimer's Disease (AD) diagnosis, as many subjects lack full imaging data due to cost and clinical constraints. While multi-modal learning leverages complementary information, most existing methods…

Image and Video Processing · Electrical Eng. & Systems 2025-08-28 Yanfei Li , Teng Yin , Wenyi Shang , Jingyu Liu , Xi Wang , Kaiyang Zhao

Purpose of review: We review the literature on the use and potential use of computational psychiatry methods in Borderline Personality Disorder. Recent findings: Computational approaches have been used in psychiatry to increase our…

Neurons and Cognition · Quantitative Biology 2018-03-06 Sarah K Fineberg , Dylan Stahl , Philip Corlett

Machine learning approaches for Alzheimer's disease (AD) diagnosis face a fundamental challenges. Clinical assessments are expensive and invasive, leaving ground truth labels available for only a fraction of neuroimaging datasets. We…

Machine Learning · Computer Science 2026-03-23 Alireza Moayedikia , Sara Fin

Studies on schizophrenia assessments using deep learning typically treat it as a classification task to detect the presence or absence of the disorder, oversimplifying the condition and reducing its clinical applicability. This traditional…

Audio and Speech Processing · Electrical Eng. & Systems 2025-09-29 Gowtham Premananth , Philip Resnik , Sonia Bansal , Deanna L. Kelly , Carol Espy-Wilson

Data is one of the essential ingredients to power deep learning research. Small datasets, especially specific to medical institutes, bring challenges to deep learning training stage. This work aims to develop a practical deep multimodal…

Machine Learning · Computer Science 2019-02-26 Faik Aydin , Maggie Zhang , Michelle Ananda-Rajah , Gholamreza Haffari

The statistical analysis of group studies in neuroscience is particularly challenging due to the complex spatio-temporal nature of the data, its multiple levels and the inter-individual variability in brain responses. In this respect,…

Methodology · Statistics 2025-05-15 Nicolò Margaritella , Vanda Inácio , Ruth King

Resting-state fMRI is commonly used for diagnosing Autism Spectrum Disorder (ASD) by using network-based functional connectivity. It has been shown that ASD is associated with brain regions and their inter-connections. However,…

Neurons and Cognition · Quantitative Biology 2022-01-04 Ranjeet Ranjan Jha , Abhishek Bhardwaj , Devin Garg , Arnav Bhavsar , Aditya Nigam

Parkinson's disease assessment has garnered growing interest in recent years, particularly with the advent of sensor data and machine learning techniques. Among these, multimodal approaches have demonstrated strong performance by…

Artificial Intelligence · Computer Science 2025-11-05 Minlin Zeng , Zhipeng Zhou , Yang Qiu , Martin J. McKeown , Zhiqi Shen

Medical image analysis increasingly relies on the integration of multiple imaging modalities to capture complementary anatomical and functional information, enabling more accurate diagnosis and treatment planning. Achieving aligned feature…

Image and Video Processing · Electrical Eng. & Systems 2025-09-04 Yunhao Liu , Suyang Xi , Shiqi Liu , Hong Ding , Chicheng Jin , Chong Zhong , Junjun He , Catherine C. Liu , Yiqing Shen

Cluster analysis aims at separating patients into phenotypically heterogenous groups and defining therapeutically homogeneous patient subclasses. It is an important approach in data-driven disease classification and subtyping. Acute…

Quantitative Methods · Quantitative Biology 2019-03-28 Eryu Xia , Xin Du , Jing Mei , Wen Sun , Suijun Tong , Zhiqing Kang , Jian Sheng , Jian Li , Changsheng Ma , Jianzeng Dong , Shaochun Li

Autism and Attention-Deficit Hyperactivity Disorder (ADHD) are two of the most commonly observed neurodevelopmental conditions in childhood. Providing a specific computational assessment to distinguish between the two can prove difficult…

Machine Learning · Computer Science 2024-11-19 Aditi Jaiswal , Dennis P. Wall , Peter Washington

We propose AttentionMixer, a unified deep learning framework for multimodal detection of brain edema that combines structural head CT (HCT) with routine clinical metadata. While HCT provides rich spatial information, clinical variables such…

The integration of different imaging modalities, such as structural, diffusion tensor, and functional magnetic resonance imaging, with deep learning models has yielded promising outcomes in discerning phenotypic characteristics and…

Image and Video Processing · Electrical Eng. & Systems 2024-10-08 Zhiyuan Li , Hailong Li , Anca L. Ralescu , Jonathan R. Dillman , Mekibib Altaye , Kim M. Cecil , Nehal A. Parikh , Lili He

The integration of diverse clinical modalities such as medical imaging and the tabular data extracted from patients' Electronic Health Records (EHRs) is a crucial aspect of modern healthcare. Integrative analysis of multiple sources can…

Computer Vision and Pattern Recognition · Computer Science 2025-04-22 Daniel Duenias , Brennan Nichyporuk , Tal Arbel , Tammy Riklin Raviv

High-throughput microarray and sequencing technology have been used to identify disease subtypes that could not be observed otherwise by using clinical variables alone. The classical unsupervised clustering strategy concerns primarily the…

Methodology · Statistics 2020-07-23 Peng Liu , Yusi Fang , Zhao Ren , Lu Tang , George C. Tseng

Longitudinal studies are frequently used in medical research and involve collecting repeated measures on individuals over time. Observations from the same individual are invariably correlated and thus an analytic approach that accounts for…