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Deep learning models based on resting-state functional magnetic resonance imaging (rs-fMRI) have been widely used to diagnose brain diseases, particularly autism spectrum disorder (ASD). Existing studies have leveraged the functional…

Machine Learning · Computer Science 2023-10-06 Wonsik Jung , Eunjin Jeon , Eunsong Kang , Heung-Il Suk

Diabetic Retinopathy (DR) is a leading cause of vision loss in working-age individuals. Early detection of DR can reduce the risk of vision loss by up to 95%, but a shortage of retinologists and challenges in timely examination complicate…

This work introduces RARE (Retrieval-Augmented Reasoning Enhancement), a versatile extension to the mutual reasoning framework (rStar), aimed at enhancing reasoning accuracy and factual integrity across large language models (LLMs) for…

Computation and Language · Computer Science 2025-06-03 Hieu Tran , Zonghai Yao , Junda Wang , Yifan Zhang , Zhichao Yang , Hong Yu

The increasing prevalence of retinal diseases poses a significant challenge to the healthcare system, as the demand for ophthalmologists surpasses the available workforce. This imbalance creates a bottleneck in diagnosis and treatment,…

Image and Video Processing · Electrical Eng. & Systems 2024-08-15 Jia-Hong Huang

Reinforcement learning (RL) has recently shown promise in predicting Alzheimer's disease (AD) progression due to its unique ability to model domain knowledge. However, it is not clear which RL algorithms are well-suited for this task.…

Therapeutic decision-making in clinical medicine constitutes a high-stakes domain in which AI guidance interacts with complex interactions among patient characteristics, disease processes, and pharmacological agents. Tasks such as drug…

Artificial Intelligence · Computer Science 2025-12-15 Tim Cofala , Christian Kalfar , Jingge Xiao , Johanna Schrader , Michelle Tang , Wolfgang Nejdl

We propose a novel mechanism for real-time (human-in-the-loop) feedback focused on false positive reduction to enhance anomaly detection models. It was designed for the lightweight deployment of a behavioral network anomaly detection model.…

Machine Learning · Computer Science 2025-02-28 Sam Pastoriza , Iman Yousfi , Christopher Redino , Marc Vucovich , Abdul Rahman , Sal Aguinaga , Dhruv Nandakumar

Automated question-answering (QA) systems increasingly rely on retrieval-augmented generation (RAG) to ground large language models (LLMs) in authoritative medical knowledge, ensuring clinical accuracy and patient safety in Artificial…

Computation and Language · Computer Science 2026-03-05 Aswini Sivakumar , Vijayan Sugumaran , Yao Qiang

Computer-aided early diagnosis of Alzheimer's disease (AD) and its prodromal form mild cognitive impairment (MCI) based on structure Magnetic Resonance Imaging (sMRI) has provided a cost-effective and objective way for early prevention and…

Image and Video Processing · Electrical Eng. & Systems 2021-11-16 Xin Zhang , Liangxiu Han , Wenyong Zhu , Liang Sun , Daoqiang Zhang

Diagnosing rare diseases presents a common challenge in clinical practice, necessitating the expertise of specialists for accurate identification. The advent of machine learning offers a promising solution, while the development of such…

Machine Learning · Computer Science 2024-03-12 Yifan Wu , Yang Liu , Yue Yang , Michael S. Yao , Wenli Yang , Xuehui Shi , Lihong Yang , Dongjun Li , Yueming Liu , James C. Gee , Xuan Yang , Wenbin Wei , Shi Gu

With the constant increase of available data in various domains, such as the Internet of Things, Social Networks or Smart Cities, it has become fundamental that agents are able to process and reason with such data in real time. Whereas…

Artificial Intelligence · Computer Science 2021-06-17 João Ferreira , Diogo Lavado , Ricardo Gonçalves , Matthias Knorr , Ludwig Krippahl , João Leite

Dyslexia is a developmental learning disorder of single word reading accuracy and/or fluency, with compelling research directed towards understanding the contributions of the visual system. While dyslexia is not an oculomotor disease,…

Complex dialog systems often use retrieved evidence to facilitate factual responses. Such RAG (Retrieval Augmented Generation) systems retrieve from massive heterogeneous data stores that are usually architected as multiple indexes or APIs…

Information Retrieval · Computer Science 2024-08-01 Ashutosh Joshi , Sheikh Muhammad Sarwar , Samarth Varshney , Sreyashi Nag , Shrivats Agrawal , Juhi Naik

Artificial Intelligence (AI) has become essential in modern healthcare, with large language models (LLMs) offering promising advances in clinical decision-making. Traditional model-based approaches, including those leveraging in-context…

Data contamination poses a significant challenge to reliable LLM evaluation, where models may achieve high performance by memorizing training data rather than demonstrating genuine reasoning capabilities. We introduce RADAR (Recall vs.…

Artificial Intelligence · Computer Science 2025-10-13 Ashish Kattamuri , Harshwardhan Fartale , Arpita Vats , Rahul Raja , Ishita Prasad

While large language models are capable diagnostic tools, the impact of multi-agent topology on diagnostic accuracy remains underexplored. This study evaluates four agent topologies, Control (single agent), Hierarchical, Adversarial, and…

Multiagent Systems · Computer Science 2026-03-10 Ahmed Almasoud

Timely and accurate diagnosis of neurodegenerative disorders, such as Alzheimer's disease, is central to disease management. Existing deep learning models require large-scale annotated datasets and often function as "black boxes".…

Computer Vision and Pattern Recognition · Computer Science 2025-04-15 Duy-Cat Can , Quang-Huy Tang , Huong Ha , Binh T. Nguyen , Oliver Y. Chén

Retrieval-Augmented Generation (RAG) effectively enhances Large Language Models (LLMs) by incorporating retrieved external knowledge into the generation process. Reasoning models improve LLM performance in multi-hop QA tasks, which require…

Computation and Language · Computer Science 2026-01-21 Guo Chen , Junjie Huang , Huaijin Xie , Fei Sun , Tao Jia

Pre-trained Multi-modal Large Language Models (MLLMs) provide a knowledge-rich foundation for post-training by leveraging their inherent perception and reasoning capabilities to solve complex tasks. However, the lack of an efficient…

Computer Vision and Pattern Recognition · Computer Science 2026-02-16 Yunshuang Nie , Bingqian Lin , Minzhe Niu , Kun Xiang , Jianhua Han , Guowei Huang , Xingyue Quan , Hang Xu , Bokui Chen , Xiaodan Liang

Alzheimer's Disease Analysis Model (ADAM) is a multi-agent reasoning large language model (LLM) framework designed to integrate and analyze multimodal data, including microbiome profiles, clinical datasets, and external knowledge bases, to…

Artificial Intelligence · Computer Science 2025-08-22 Ziyuan Huang , Vishaldeep Kaur Sekhon , Roozbeh Sadeghian , Maria L. Vaida , Cynthia Jo , Doyle Ward , Vanni Bucci , John P. Haran