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In this paper, we ask if it is possible to increase the interpretability in multivariate analysis by aligning and projecting covariates onto comparative subspaces. We demonstrate our method as well as the interpretative power of PLS…

Quantitative Methods · Quantitative Biology 2021-03-18 Edward Tjörnhammar , Richard Tjörnhammar

Speech holds promise as a cost-effective and non-invasive biomarker for neurological conditions such as Parkinson's disease (PD). While deep learning systems trained on raw audio can find subtle signals not available from hand-crafted…

Audio and Speech Processing · Electrical Eng. & Systems 2025-07-24 Peter Plantinga , Jen-Kai Chen , Roozbeh Sattari , Mirco Ravanelli , Denise Klein

In complex visual recognition tasks it is typical to adopt multiple descriptors, that describe different aspects of the images, for obtaining an improved recognition performance. Descriptors that have diverse forms can be fused into a…

Computer Vision and Pattern Recognition · Computer Science 2015-06-15 Jayaraman J. Thiagarajan , Karthikeyan Natesan Ramamurthy , Andreas Spanias

Integrating whole-slide images (WSIs) and bulk transcriptomics for predicting patient survival can improve our understanding of patient prognosis. However, this multimodal task is particularly challenging due to the different nature of…

Computer Vision and Pattern Recognition · Computer Science 2024-04-16 Guillaume Jaume , Anurag Vaidya , Richard Chen , Drew Williamson , Paul Liang , Faisal Mahmood

Interpretable Multi-Task Learning can be expressed as learning a sparse graph of the task relationship based on the prediction performance of the learned models. Since many natural phenomenon exhibit sparse structures, enforcing sparsity on…

Machine Learning · Computer Science 2020-09-14 Francesco Alesiani , Shujian Yu , Ammar Shaker , Wenzhe Yin

Sparse Autoencoder (SAE) has emerged as a powerful tool for mechanistic interpretability of large language models. Recent works apply SAE to protein language models (PLMs), aiming to extract and analyze biologically meaningful features from…

Quantitative Methods · Quantitative Biology 2026-01-21 Xiangyu Liu , Haodi Lei , Yi Liu , Yang Liu , Wei Hu

Cell counting in biomedical imaging is pivotal for various clinical applications, yet the interpretability of deep learning models in this domain remains a significant challenge. We propose a novel prototype-based method for interpretable…

Computer Vision and Pattern Recognition · Computer Science 2025-11-26 Abdurahman Ali Mohammed , Wallapak Tavanapong , Catherine Fonder , Donald S. Sakaguchi

Sequential generative models conditioned on uncertain rewards are central to AI-driven scientific discovery, yet the epistemic uncertainty they inherit from imperfect reward estimates remains unquantified. We propagate this uncertainty…

Dictionary learning is a challenge topic in many image processing areas. The basic goal is to learn a sparse representation from an overcomplete basis set. Due to combining the advantages of generic multiscale representations with learning…

Computer Vision and Pattern Recognition · Computer Science 2017-04-17 Rui Chen , Huizhu Jia , Xiaodong Xie , Wen Gao

In data-driven drug discovery, designing molecular descriptors is a very important task. Deep generative models such as variational autoencoders (VAEs) offer a potential solution by designing descriptors as probabilistic latent vectors…

Machine Learning · Computer Science 2023-08-23 Daiki Koge , Naoaki Ono , Shigehiko Kanaya

Sparse autoencoders (SAEs) are used to decompose neural network activations into sparsely activating features, but many SAE features are only interpretable at high activation strengths. To address this issue we propose to use binary sparse…

Machine Learning · Computer Science 2025-10-01 Lucia Quirke , Stepan Shabalin , Nora Belrose

Deep neural networks have been well-known for their superb handling of various machine learning and artificial intelligence tasks. However, due to their over-parameterized black-box nature, it is often difficult to understand the prediction…

Machine Learning · Computer Science 2022-07-18 Xuhong Li , Haoyi Xiong , Xingjian Li , Xuanyu Wu , Xiao Zhang , Ji Liu , Jiang Bian , Dejing Dou

We develop the sparse VAE for unsupervised representation learning on high-dimensional data. The sparse VAE learns a set of latent factors (representations) which summarize the associations in the observed data features. The underlying…

Machine Learning · Statistics 2025-04-16 Gemma E. Moran , Dhanya Sridhar , Yixin Wang , David M. Blei

Understanding how features evolve across layers in deep neural networks is a fundamental challenge in mechanistic interpretability, particularly due to polysemanticity and feature superposition. While Sparse Autoencoders (SAEs) have been…

Machine Learning · Computer Science 2025-03-04 Nikita Balagansky , Ian Maksimov , Daniil Gavrilov

We show how fitting sparse linear models over learned deep feature representations can lead to more debuggable neural networks. These networks remain highly accurate while also being more amenable to human interpretation, as we demonstrate…

Machine Learning · Computer Science 2021-05-12 Eric Wong , Shibani Santurkar , Aleksander Mądry

Interpretable entity representations (IERs) are sparse embeddings that are "human-readable" in that dimensions correspond to fine-grained entity types and values are predicted probabilities that a given entity is of the corresponding type.…

Computation and Language · Computer Science 2022-12-06 Diego Garcia-Olano , Yasumasa Onoe , Joydeep Ghosh , Byron C. Wallace

We focus on multi-domain Neural Machine Translation, with the goal of developing efficient models which can handle data from various domains seen during training and are robust to domains unseen during training. We hypothesize that Sparse…

Computation and Language · Computer Science 2024-07-02 Nadezhda Chirkova , Vassilina Nikoulina , Jean-Luc Meunier , Alexandre Bérard

Sparse reduced-rank regression is an important tool to uncover meaningful dependence structure between large numbers of predictors and responses in many big data applications such as genome-wide association studies and social media…

Methodology · Statistics 2016-08-15 Mohammad Taha Bahadori , Zemin Zheng , Yan Liu , Jinchi Lv

Rapid, reliable, and accurate interpretation of medical time-series signals is crucial for high-stakes clinical decision-making. Deep learning methods offered unprecedented performance in medical signal processing but at a cost: they were…

Signal Processing · Electrical Eng. & Systems 2024-10-08 Sully F. Chen , Zhicheng Guo , Cheng Ding , Xiao Hu , Cynthia Rudin

Research in the past years introduced Steered Mixture-of-Experts (SMoE) as a framework to form sparse, edge-aware models for 2D- and higher dimensional pixel data, applicable to compression, denoising, and beyond, and capable to compete…

Image and Video Processing · Electrical Eng. & Systems 2023-05-08 Elvira Fleig , Erik Bochinski , Thomas Sikora
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