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Sparse autoencoders (SAEs) have become a central tool for interpreting language models. However, two key SAE analyses that remain difficult to scale are (1) matching semantically similar features across multi-layers and (2) compressing…

Machine Learning · Computer Science 2026-05-28 Tue M. Cao , Nguyen Do , My T. Thai

Although considerable effort has been dedicated to improving the solution to the hyperspectral unmixing problem, non-idealities such as complex radiation scattering and endmember variability negatively impact the performance of most…

Image and Video Processing · Electrical Eng. & Systems 2023-10-05 Ricardo Augusto Borsoi , Deniz Erdoğmuş , Tales Imbiriba

High resolution microarrays and second-generation sequencing platforms are powerful tools to investigate genome-wide alterations in DNA copy number, methylation and gene expression associated with a disease. An integrated genomic profiling…

Applications · Statistics 2013-04-22 Ronglai Shen , Sijian Wang , Qianxing Mo

Recent advances in high-throughput sequencing technologies have enabled the extraction of multiple features that depict patient samples at diverse and complementary molecular levels. The generation of such data has led to new challenges in…

Genomics · Quantitative Biology 2022-09-14 Hakim Benkirane , Yoann Pradat , Stefan Michiels , Paul-Henry Cournède

Being able to interpret, or explain, the predictions made by a machine learning model is of fundamental importance. This is especially true when there is interest in deploying data-driven models to make high-stakes decisions, e.g. in…

Machine Learning · Computer Science 2019-10-01 An-phi Nguyen , María Rodríguez Martínez

Sparse autoencoders have become a standard tool for uncovering interpretable latent representations in neural networks. Yet salient concepts often span manifolds that current linear methods cannot capture without post hoc analysis. This…

Machine Learning · Computer Science 2026-05-12 Thomas Dooms , Ward Gauderis , Geraint Wiggins , Jose Oramas

Without any means of interpretation, neural networks that predict molecular properties and bioactivities are merely black boxes. We will unravel these black boxes and will demonstrate approaches to understand the learned representations…

Machine Learning · Computer Science 2019-03-19 Kristina Preuer , Günter Klambauer , Friedrich Rippmann , Sepp Hochreiter , Thomas Unterthiner

Mixture-of-Experts (MoE) architectures have become the dominant choice for scaling Large Language Models (LLMs), activating only a subset of parameters per token. While MoE architectures are primarily adopted for computational efficiency,…

Computation and Language · Computer Science 2026-05-19 Jeremy Herbst , Stefan Wermter , Jae Hee Lee

A recent line of work has shown promise in using sparse autoencoders (SAEs) to uncover interpretable features in neural network representations. However, the simple linear-nonlinear encoding mechanism in SAEs limits their ability to perform…

Machine Learning · Computer Science 2025-01-31 Charles O'Neill , Alim Gumran , David Klindt

Neural networks have greatly boosted performance in computer vision by learning powerful representations of input data. The drawback of end-to-end training for maximal overall performance are black-box models whose hidden representations…

Computer Vision and Pattern Recognition · Computer Science 2020-04-29 Patrick Esser , Robin Rombach , Björn Ommer

We present a new deep unfolding network for analysis-sparsity-based Compressed Sensing. The proposed network coined Decoding Network (DECONET) jointly learns a decoder that reconstructs vectors from their incomplete, noisy measurements and…

Information Theory · Computer Science 2023-06-21 Vicky Kouni , Yannis Panagakis

The extraction of geoelectric structural information from airborne transient electromagnetic(ATEM)data primarily involves data processing and inversion. Conventional methods rely on empirical parameter selection, making it difficult to…

Machine Learning · Computer Science 2025-03-31 Shuang Wang , Xuben Wang , Fei Deng , Xiaodong Yu , Peifan Jiang , Lifeng Mao

A recent cutting-edge topic in multimodal modeling is to unify visual comprehension and generation within a single model. However, the two tasks demand mismatched decoding regimes and visual representations, making it non-trivial to jointly…

Linear probes and sparse autoencoders consistently recover meaningful structure from transformer representations -- yet why should such simple methods succeed in deep, nonlinear systems? We show this is not merely an empirical regularity…

Machine Learning · Computer Science 2026-02-11 Andres Saurez , Yousung Lee , Dongsoo Har

Multimodal generative models should be able to learn a meaningful latent representation that enables a coherent joint generation of all modalities (e.g., images and text). Many applications also require the ability to accurately sample…

Machine Learning · Computer Science 2021-08-02 Svetlana Kutuzova , Oswin Krause , Douglas McCloskey , Mads Nielsen , Christian Igel

The functional and structural representation of the brain as a complex network is marked by the fact that the comparison of noisy and intrinsically correlated high-dimensional structures between experimental conditions or groups shuns…

Neurons and Cognition · Quantitative Biology 2013-10-25 Tommaso Furlanello , Marco Cristoforetti , Cesare Furlanello , Giuseppe Jurman

Over the past several years, legal applications of deep learning have been on the rise. However, as with other high-stakes decision making areas, the requirement for interpretability is of crucial importance. Current models utilized by…

Machine Learning · Computer Science 2022-01-05 Rohan Bhambhoria , Hui Liu , Samuel Dahan , Xiaodan Zhu

Pathology plays an important role in disease diagnosis, treatment decision-making and drug development. Previous works on interpretability for machine learning models on pathology images have revolved around methods such as attention value…

Balancing predictive power and interpretability has long been a challenging research area, particularly in powerful yet complex models like neural networks, where nonlinearity obstructs direct interpretation. This paper introduces a novel…

Machine Learning · Computer Science 2025-02-20 Antoine Ledent , Peng Liu

Existing machine learning methods for molecular (e.g., gene) embeddings are restricted to specific tasks or data modalities, limiting their effectiveness within narrow domains. As a result, they fail to capture the full breadth of gene…