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We present a quantitative evaluation to understand the effect of zero-shot large-language model (LLMs) and prompting uses on chart reading tasks. We asked LLMs to answer 107 visualization questions to compare inference accuracies between…

Human-Computer Interaction · Computer Science 2025-10-09 Kaichun Yang , Jian Chen

Gliomas, a common type of malignant brain tumor, present significant surgical challenges due to their similarity to healthy tissue. Preoperative Magnetic Resonance Imaging (MRI) images are often ineffective during surgery due to factors…

Image and Video Processing · Electrical Eng. & Systems 2024-08-28 Samir Kassam , Angelo Markham , Katie Vo , Yashas Revanakara , Michael Lam , Kevin Zhu

Despite growing reference libraries and advanced computational tools, progress in the field of metabolomics remains constrained by low rates of annotating measured spectra. The recent developments of large language models (LLMs) have led to…

Quantitative Methods · Quantitative Biology 2025-11-14 Margaret R. Martin , Soha Hassoun

Classification of pathological images is the basis for automatic cancer diagnosis. Despite that deep learning methods have achieved remarkable performance, they heavily rely on labeled data, demanding extensive human annotation efforts. In…

Computer Vision and Pattern Recognition · Computer Science 2025-07-30 Lanfeng Zhong , Zongyao Huang , Yang Liu , Wenjun Liao , Shichuan Zhang , Guotai Wang , Shaoting Zhang

Accurate intraoperative assessment of glioma infiltration is essential for maximizing tumor resection while preserving functional brain tissue. Fluorescence lifetime imaging (FLIm) offers real-time, label-free biochemical contrast, but its…

Computer Vision and Pattern Recognition · Computer Science 2026-04-30 Silvia Noble Anbunesan , Mohamed Abul Hassan , Jinyi Qi , Lisanne Kraft , Han Sung Lee , Orin Bloch , Laura Marcu

Artificial Intelligence models have demonstrated significant success in diagnosing skin diseases, including cancer, showing the potential to assist clinicians in their analysis. However, the interpretability of model predictions must be…

Computer Vision and Pattern Recognition · Computer Science 2025-08-29 Max Torop , Masih Eskandar , Nicholas Kurtansky , Jinyang Liu , Jochen Weber , Octavia Camps , Veronica Rotemberg , Jennifer Dy , Kivanc Kose

Precise prognostic modeling of glioblastoma (GBM) under varying treatment interventions is essential for optimizing clinical outcomes. While generative AI has shown promise in simulating GBM evolution, existing methods typically treat…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Chenhui Wang , Boyun Zheng , Liuxin Bao , Zhihao Peng , Peter Y. M. Woo , Hongming Shan , Yixuan Yuan

The effective management of brain tumors relies on precise typing, subtyping, and grading. This study advances patient care with findings from rigorous multiple instance learning experimentations across various feature extractors and…

Computer Vision and Pattern Recognition · Computer Science 2024-03-11 Ekansh Chauhan , Amit Sharma , Megha S Uppin , C. V. Jawahar , P. K. Vinod

Deep learning has significantly advanced automated brain tumor diagnosis, yet clinical adoption remains limited by interpretability and computational constraints. Conventional models often act as opaque ''black boxes'' and fail to quantify…

Computer Vision and Pattern Recognition · Computer Science 2026-02-25 Sepehr Salem Ghahfarokhi , M. Moein Esfahani , Raj Sunderraman , Vince Calhoun , Mohammed Alser

Machine learning models have utilized semantic features, deep features, or both to assess lung nodule malignancy. However, their reliance on manual annotation during inference, limited interpretability, and sensitivity to imaging variations…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Luoting Zhuang , Seyed Mohammad Hossein Tabatabaei , Ramin Salehi-Rad , Linh M. Tran , Denise R. Aberle , Ashley E. Prosper , William Hsu

This study evaluates the performance of large language models (LLMs) and the HINT model in predicting clinical trial outcomes, focusing on metrics including Balanced Accuracy, Matthews Correlation Coefficient (MCC), Recall, and Specificity.…

Machine Learning · Computer Science 2025-03-19 Shuyi Jin , Lu Chen , Hongru Ding , Meijie Wang , Lun Yu

This paper describes a rapid feasibility study of using GPT-4, a large language model (LLM), to (semi)automate data extraction in systematic reviews. Despite the recent surge of interest in LLMs there is still a lack of understanding of how…

Computation and Language · Computer Science 2025-02-14 Lena Schmidt , Kaitlyn Hair , Sergio Graziosi , Fiona Campbell , Claudia Kapp , Alireza Khanteymoori , Dawn Craig , Mark Engelbert , James Thomas

Both medical care and observational studies in oncology require a thorough understanding of a patient's disease progression and treatment history, often elaborately documented in clinical notes. Despite their vital role, no current oncology…

Computation and Language · Computer Science 2024-03-18 Madhumita Sushil , Vanessa E. Kennedy , Divneet Mandair , Brenda Y. Miao , Travis Zack , Atul J. Butte

Large language models (LLMs) have shown considerable promise in clinical natural language processing, yet few domain-specific datasets exist to rigorously evaluate their performance on radiology tasks. In this work, we introduce an…

Computation and Language · Computer Science 2025-11-18 Namu Park , Giridhar Kaushik Ramachandran , Kevin Lybarger , Fei Xia , Ozlem Uzuner , Meliha Yetisgen , Martin Gunn

Image-guided surgery demands adaptive, real-time decision support, yet static AI models struggle with structured task planning and providing interactive guidance. Large language models (LLMs)-powered agents offer a promising solution by…

Computer Vision and Pattern Recognition · Computer Science 2025-11-13 Jiayuan Huang , Runlong He , Danyal Zaman Khan , Evangelos B. Mazomenos , Danail Stoyanov , Hani Marcus , Linzhe Jiang , Matthew J Clarkson , Mobarak I. Hoque

Despite the widespread use of statistical prior models in various fields, such models for neural network gradients have long been overlooked. The inherent challenge stems from their high-dimensional structures and complex interdependencies,…

Machine Learning · Computer Science 2025-01-23 Hui-Po Wang , Mario Fritz

This study integrates PET metabolic information with CT anatomical structures to establish a 3D multimodal segmentation dataset for lymphoma based on whole-body FDG PET/CT examinations, which bridges the gap of the lack of standardised…

Image and Video Processing · Electrical Eng. & Systems 2025-12-08 Jiajun Ding , Beiyao Zhu , Xiaosheng Liu , Lishen Zhang , Zhao Liu

The increasing volume of drug combinations in modern therapeutic regimens needs reliable methods for predicting drug-drug interactions (DDIs). While Large Language Models (LLMs) have revolutionized various domains, their potential in…

Machine Learning · Computer Science 2025-02-12 Gabriele De Vito , Filomena Ferrucci , Athanasios Angelakis

Inverse graphics -- the task of inverting an image into physical variables that, when rendered, enable reproduction of the observed scene -- is a fundamental challenge in computer vision and graphics. Successfully disentangling an image…

Computer Vision and Pattern Recognition · Computer Science 2024-08-27 Peter Kulits , Haiwen Feng , Weiyang Liu , Victoria Abrevaya , Michael J. Black

Objectives:To develop a framework for obtaining dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) derived relative cerebral blood volume (rCBV) maps without gadolinium-based contrast agent (GBCA) injection. Methods:This…

Medical Physics · Physics 2023-08-29 Lu Wang , Zhen Xing , Congbo Cai , Zhong Chen , Dairong Cao , Shuhui Cai