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The rapid population aging has stimulated the development of assistive devices that provide personalized medical support to the needies suffering from various etiologies. One prominent clinical application is a computer-assisted speech…

Computation and Language · Computer Science 2019-05-22 Emre Yılmaz , Vikramjit Mitra , Ganesh Sivaraman , Horacio Franco

Depression is a serious medical condition that is suffered by a large number of people around the world. It significantly affects the way one feels, causing a persistent lowering of mood. In this paper, we propose a novel attention-based…

Computers and Society · Computer Science 2019-04-17 Syed Arbaaz Qureshi , Mohammed Hasanuzzaman , Sriparna Saha , Gaël Dias

Autism Spectrum Disorders (ASD) describe a heterogeneous set of conditions classified as neurodevelopmental disorders. Although the mechanisms underlying ASD are not yet fully understood, more recent literature focused on multiple genetics…

Signal Processing · Electrical Eng. & Systems 2025-01-31 Jessica Vacca , Natascia Brondino , Fabio Dell'Acqua , Anna Vizziello , Pietro Savazzi

Automatic detection and severity assessment of dysarthria are crucial for delivering targeted therapeutic interventions to patients. While most existing research focuses primarily on speech modality, this study introduces a novel approach…

Artificial Intelligence · Computer Science 2025-04-29 Anuprabha M , Krishna Gurugubelli , V Kesavaraj , Anil Kumar Vuppala

Recent works in pathological speech analysis have increasingly relied on powerful self-supervised speech representations, leading to promising results. However, the complex, black-box nature of these embeddings and the limited research on…

Computer Vision and Pattern Recognition · Computer Science 2025-02-11 David Gimeno-Gómez , Catarina Botelho , Anna Pompili , Alberto Abad , Carlos-D. Martínez-Hinarejos

This study examines the relationship between speech representations and the hierarchical structure of cognitive assessment in mild cognitive impairment. Utilizing 5,754 German neuropsychological assessment recordings, we evaluate six…

This study presents the development and testing of a conversational speech system designed for robots to detect speech biomarkers indicative of cognitive impairments in people living with dementia (PLwD). The system integrates a backend…

Computation and Language · Computer Science 2025-02-18 Rohith Perumandla , Young-Ho Bae , Diego Izaguirre , Esther Hwang , Andrew Murphy , Long-Jing Hsu , Selma Sabanovic , Casey C. Bennett

Modularity plays an important role in brain networks' architecture and influences its dynamics and the ability to integrate and segregate different modules of cerebral regions. Alterations in community structure are associated with several…

Neurons and Cognition · Quantitative Biology 2018-05-14 M. Cinelli , I. Echegoyen , M. Oliveira , S. Orellana , T. Gili

This survey presents the most relevant neural network models of autism spectrum disorder and schizophrenia, from the first connectionist models to recent deep network architectures. We analyzed and compared the most representative symptoms…

Neurons and Cognition · Quantitative Biology 2019-11-22 Pablo Lanillos , Daniel Oliva , Anja Philippsen , Yuichi Yamashita , Yukie Nagai , Gordon Cheng

Brain Functional Networks (BFNs), graph theoretical models of brain activity data, provide a systems perspective of complex functional connectivity within the brain. Neurological disorders are known to have basis in abnormal functional…

Quantitative Methods · Quantitative Biology 2016-08-30 Megha Singh , Rahul Badhwar , Ganesh Bagler

Machine learning models have been successfully employed in the diagnosis of Schizophrenia disease. The impact of classification models and the feature selection techniques on the diagnosis of Schizophrenia have not been evaluated. Here, we…

Machine Learning · Computer Science 2022-07-05 M. Tanveer , Jatin Jangir , M. A. Ganaie , Iman Beheshti , M. Tabish , Nikunj Chhabra

Coherence is a widely used measure to assess linear relationships between time series. However, it fails to capture nonlinear dependencies. To overcome this limitation, this paper introduces the notion of residual spectral density as a…

Statistics Theory · Mathematics 2024-05-21 Yuichi Goto , Xuze Zhang , Benjamin Kedem , Shuo Chen

The ability to accurately detect onset of dementia is important in the treatment of the disease. Clinically, the diagnosis of Alzheimer Disease (AD) and Mild Cognitive Impairment (MCI) patients are based on an integrated assessment of…

Signal Processing · Electrical Eng. & Systems 2022-11-18 Wan-Ting Hsieh , Jeremy Lefort-Besnard , Hao-Chun Yang , Li-Wei Kuo , Chi-Chun Lee

Early and accurate diagnosis of Alzheimer Disease is critical for effective clinical intervention, particularly in distinguishing it from Mild Cognitive Impairment, a prodromal stage marked by subtle structural changes. In this study, we…

Image and Video Processing · Electrical Eng. & Systems 2025-10-08 Fahad Mostafa , Kannon Hossain , Hafiz Khan

Scientists routinely compare gene expression levels in cases versus controls in part to determine genes associated with a disease. Similarly, detecting case-control differences in co-expression among genes can be critical to understanding…

Methodology · Statistics 2017-10-23 Lingxue Zhu , Jing Lei , Bernie Devlin , Kathryn Roeder

Functional connectivity plays an essential role in modern neuroscience. The modality sheds light on the brain's functional and structural aspects, including mechanisms behind multiple pathologies. One such pathology is schizophrenia which…

Neurons and Cognition · Quantitative Biology 2022-06-07 Maksim Zhdanov , Saskia Steinmann , Nico Hoffmann

Background:Speech patterns have emerged as potential diagnostic markers for conditions with varying etiologies. Machine learning (ML) presents an opportunity to harness these patterns for accurate disease diagnosis. Objective: This review…

Computation and Language · Computer Science 2025-03-10 Birger Moell , Fredrik Sand Aronsson , Per Östberg , Jonas Beskow

Dysarthria, a motor speech disorder, affects intelligibility and requires targeted interventions for effective communication. In this work, we investigate automated mispronunciation feedback by collecting a dysarthric speech dataset from…

Audio and Speech Processing · Electrical Eng. & Systems 2025-06-03 Seohyun Park , Chitralekha Gupta , Michelle Kah Yian Kwan , Xinhui Fung , Alexander Wenjun Yip , Suranga Nanayakkara

Acoustic-to-articulatory inversion (AAI) involves mapping from the acoustic to the articulatory space. Signal-processing features like the MFCCs, have been widely used for the AAI task. For subjects with dysarthric speech, AAI is…

Audio and Speech Processing · Electrical Eng. & Systems 2024-02-13 Sarthak Kumar Maharana , Krishna Kamal Adidam , Shoumik Nandi , Ajitesh Srivastava

This paper is a submission to the Alzheimer's Dementia Recognition through Spontaneous Speech (ADReSS) challenge, which aims to develop methods that can assist in the automated prediction of severity of Alzheimer's Disease from speech data.…

Machine Learning · Computer Science 2021-06-18 Morteza Rohanian , Julian Hough , Matthew Purver