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Biomedical retrieval-augmented large language models (LLMs) often face evidence that is incomplete, misleading, or internally contradictory, yet evaluation usually emphasizes answer accuracy under helpful context rather than reliability…

Computation and Language · Computer Science 2026-05-15 Yikun Han , Mengfei Lan , Halil Kilicoglu

Integrating data from multiple heterogeneous sources has become increasingly popular to achieve a large sample size and diverse study population. This paper reviews development in causal inference methods that combines multiple datasets…

Methodology · Statistics 2021-10-05 Xu Shi , Ziyang Pan , Wang Miao

Simulation-Based Inference (SBI) offers a principled and flexible framework for conducting Bayesian inference in any situation where forward simulations are feasible. However, validating the accuracy and reliability of the inferred…

Instrumentation and Methods for Astrophysics · Physics 2026-01-21 James Alvey , Carlo R. Contaldi , Mauro Pieroni

The transmission dynamics of an epidemic are rarely homogeneous. Super-spreading events and super-spreading individuals are two types of heterogeneous transmissibility. Inference of super-spreading is commonly carried out on secondary case…

Quantitative Methods · Quantitative Biology 2025-01-23 Hannah Craddock , Simon EF Spencer , Xavier Didelot

Recent work has shown that models trained to the same objective, and which achieve similar measures of accuracy on consistent test data, may nonetheless behave very differently on individual predictions. This inconsistency is undesirable in…

Machine Learning · Computer Science 2021-11-17 Emily Black , Klas Leino , Matt Fredrikson

Accurate estimation of counterfactual outcomes in high-dimensional data is crucial for decision-making and understanding causal relationships and intervention outcomes in various domains, including healthcare, economics, and social…

Machine Learning · Computer Science 2024-07-31 Jiageng Zhu , Hanchen Xie , Jiazhi Li , Wael Abd-Almageed

When a latent shoeprint is discovered at a crime scene, forensic analysts inspect it for distinctive patterns of wear such as scratches and holes (known as accidentals) on the source shoe's sole. If its accidentals correspond to those of a…

Applications · Statistics 2020-02-28 Neil A. Spencer , Jared S. Murray

Medical devices improve healthcare outcomes but often involve sustainability conflicts across environmental, economic, and social pillars. Existing approaches typically prioritize one or two pillars and lack a unified framework to assess…

Physics and Society · Physics 2025-12-16 Apala Chakrabarti

Multi-sensor data fusion technology plays an important role in real applications. Because of the flexibility and effectiveness in modelling and processing the uncertain information regardless of prior probabilities, Dempster-Shafer evidence…

Artificial Intelligence · Computer Science 2018-06-06 Fuyuan Xiao

In contested domains, instruction-tuned language models must balance user-alignment pressures against faithfulness to the in-context evidence. To evaluate this tension, we introduce a controlled epistemic-conflict framework grounded in the…

Computation and Language · Computer Science 2026-03-23 Sai Koneru , Elphin Joe , Christine Kirchhoff , Jian Wu , Sarah Rajtmajer

We introduce a general framework that extends Bayesian inference by allowing the researcher to explicitly encode confidence in each source of uncertainty within the model. This mechanism provides a new handle for model design and…

Methodology · Statistics 2026-05-06 Rafael Mouallem Rosa , Julyan Arbel , Hien Duy Nguyen

Variational inference is a popular method for estimating model parameters and conditional distributions in hierarchical and mixed models, which arise frequently in many settings in the health, social, and biological sciences. Variational…

Methodology · Statistics 2019-01-10 Ted Westling , Tyler H. McCormick

Learning methods using synthetic data have attracted attention as an effective approach for increasing the diversity of training data while reducing collection costs, thereby improving the robustness of model discrimination. However, many…

Computer Vision and Pattern Recognition · Computer Science 2026-04-06 Koshiro Nagano , Ryo Fujii , Ryo Hachiuma , Fumiaki Sato , Taiki Sekii , Hideo Saito

Due to numerous public information sources and services, many methods to combine heterogeneous data were proposed recently. However, general end-to-end solutions are still rare, especially systems taking into account different context…

Information Retrieval · Computer Science 2018-07-27 Slavko Žitnik , Lovro Šubelj , Dejan Lavbič , Olegas Vasilecas , Marko Bajec

With the emergence of dynamic multiplex networks, corresponding to graphs where multiple types of edges evolve over time, a key inferential task is to determine whether the layers associated with different edge types differ in their…

Methodology · Statistics 2025-12-04 Maximilian Baum , Francesco Sanna Passino , Axel Gandy

Artificial Neural Networks (ANNs) often represent conflicts between features, arising naturally during training as the network learns to integrate diverse and potentially disagreeing inputs to better predict the target variable. Despite…

Machine Learning · Computer Science 2025-06-03 Adam Dejl , Dekai Zhang , Hamed Ayoobi , Matthew Williams , Francesca Toni

Model inadequacy and measurement uncertainty are two of the most confounding aspects of inference and prediction in quantitative sciences. The process of scientific inference (the inverse problem) and prediction (the forward problem)…

Data Analysis, Statistics and Probability · Physics 2017-11-30 Amir Shahmoradi

Diffusion models have recently emerged as powerful learners for simulation-based inference (SBI), enabling fast and accurate estimation of latent parameters from simulated and real data. Their score-based formulation offers a flexible way…

Machine Learning · Statistics 2026-01-30 Jonas Arruda , Niels Bracher , Ullrich Köthe , Jan Hasenauer , Stefan T. Radev

A common assumption in causal inference from observational data is that there is no hidden confounding. Yet it is, in general, impossible to verify this assumption from a single dataset. Under the assumption of independent causal mechanisms…

Methodology · Statistics 2023-11-07 Rickard K. A. Karlsson , Jesse H. Krijthe

Adoption of machine learning models in healthcare requires end users' trust in the system. Models that provide additional supportive evidence for their predictions promise to facilitate adoption. We define consistent evidence to be both…

Computer Vision and Pattern Recognition · Computer Science 2021-11-16 Peiqi Wang , Ruizhi Liao , Daniel Moyer , Seth Berkowitz , Steven Horng , Polina Golland