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The FLASH effect, characterized by potential sparing of organs at risk (OAR) through ultra-high dose rate irradiation, has garnered significant attention for its capability to address indications previously untreatable at conventional dose…

Medical Physics · Physics 2024-10-16 S. Wuyckens , M. Chocan Vera , R. Nilsson , V. Wase , D. Di Perri , X. Geets , E. Sterpin , J. A. Lee

With X-ray radiation protection and dose management constantly gaining interest in interventional radiology, novel procedures often undergo prospective dose studies using anthropomorphic phantoms to determine expected dose values. Due to…

Photon counting CT (PCCT) has been a research focus in the last two decades. Recent studies and advancements have demonstrated that systems using semiconductor-based photon counting detectors (PCDs) have the potential to provide better…

X-ray imaging dose from serial cone-beam CT (CBCT) scans raises a clinical concern in most image guided radiation therapy procedures. It is the goal of this paper to develop a fast GPU-based algorithm to reconstruct high quality CBCT images…

Medical Physics · Physics 2015-05-19 Xun Jia , Bin Dong , Yifei Lou , Steve B. Jiang

Purpose: Beam angle selection is critical in proton therapy treatment planning, yet automated approaches remain underexplored. This study presents and evaluates GAMBAS, a novel, fast machine learning model for automatic beam angle…

Multi-energy CT takes advantage of the non-linearly varying attenuation properties of elemental media with respect to energy, enabling more precise material identification than single-energy CT. The increased precision comes with the cost…

Medical Physics · Physics 2020-02-14 Jussi Toivanen , Alexander Meaney , Samuli Siltanen , Ville Kolehmainen

Introduction: Quantification of dynamic contrast-enhanced (DCE)-MRI has the potential to provide valuable clinical information, but robust pharmacokinetic modeling remains a challenge for clinical adoption. Methods: A 7-layer neural network…

Medical Physics · Physics 2024-05-22 Ouri Cohen , Soudabeh Kargar , Sungmin Woo , Alberto Vargas , Ricardo Otazo

Objective. Proton beams enable localized dose delivery. Accurate range estimation is essential, but planning still relies on X-ray CT, which introduces uncertainty in stopping power and range. Proton CT measures water equivalent thickness…

Medical Physics · Physics 2025-09-15 Atiq Ur Rahman , Chun-Chieh Wang , Shu-Wei Wu , Tsi-Chian Chao , I-Chun Cho

Objective: To assess the accuracy and computational performance of a stochastic differential equation (SDE)--based model for proton beam dose calculation by benchmarking against Geant4 in simplified phantom geometries. Approach: Building on…

Dual-energy CT (DECT) has been widely investigated to generate more informative and more accurate images in the past decades. For example, Dual-Energy Alternating Minimization (DEAM) algorithm achieves sub-percentage uncertainty in…

Image and Video Processing · Electrical Eng. & Systems 2021-08-03 Tao Ge , Maria Medrano , Rui Liao , David G. Politte , Jeffrey F. Williamson , Joseph A. O'Sullivan

The use of CT imaging is important for screening, diagnosis, therapy planning, and prognosis of lung cancers. Unfortunately, due to differences in imaging protocols and scanner models, CT images acquired by different means may show large…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Md Shifatul Ahsan Apurba , Md Selim , Jin Chen

Modern PET systems reach a spatial resolution of 3-10 mm. A disadvantage of this technique is the diffusion of the positron before its decay with a typical range of ca. 1 mm (depending on its energy). This motion and Compton scattering of…

Instrumentation and Detectors · Physics 2012-02-03 C. Lang , D. Habs , P. G. Thirolf , A. Zoglauer

Pancreatic cancer with more than 60,000 new cases each year has less than 10 percent 5-year overall survival. Radiation therapy (RT) is an effective treatment for Locally advanced pancreatic cancer (LAPC). The current clinical RT workflow…

Medical Physics · Physics 2023-06-07 Hamed Hooshangnejad , Quan Chen , Xue Feng , Rui Zhang , Kai Ding

For the in vivo range verification in proton therapy, it has been tried to measure the spatial distribution of the prompt gammas generated by the proton-induced interactions with the close relationship with the proton dose distribution.…

Medical Physics · Physics 2015-03-13 Wook-Geun Shin , Chul Hee Min , Jae-Ik Shin , Jong Hwi Jeong , Se Byeong Lee

Purpose: To develop a DL-based PBSPT dose prediction workflow with high accuracy and balanced complexity to support on-line adaptive proton therapy clinical decision and subsequent replanning. Methods: PBSPT plans of 103 prostate cancer…

Objectives: This study aims to characterize the dose-performance relationship for opportunistic CT and disentangle the contributions of segmentation failure and dose-dependent HU bias to performance degradation. Methods: Simulated low-dose…

Proton computed tomography (CT) is similar to x-ray CT but relies on protons rather than photons to form an image. In its most common operation mode, the measured quantity is the amount of energy that a proton has lost while traversing the…

Medical Physics · Physics 2022-08-17 Nils Krah , Denis Dauvergne , Jean Michel Létang , Simon Rit , Étienne Testa

Background: Individual skull models of bone density and geometry are important when planning the expected transcranial ultrasound acoustic field and estimating mechanical and thermal safety in low-intensity transcranial ultrasound…

OBJECTIVE: This study evaluated the accuracy in localisation and distribution of real-time three-dimensional (4-D) ultrasound-guided biopsies on a prostate phantom. METHODS: A prostate phantom was created. A three-dimensional real-time…

Purpose: The goal is to develop a new architecture for computed tomography (CT) which is at an ultra-low-dose for developing countries, especially in rural areas. Methods: The proposed scheme is inspired by the recently developed…

Medical Physics · Physics 2013-12-23 Fenglin Liu , Hengyong Yu , Wenxiang Cong , Ge Wang
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