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Structure entails function and thus a structural description of the brain will help to understand its function and may provide insights into many properties of brain systems, from their robustness and recovery from damage, to their dynamics…

Neurons and Cognition · Quantitative Biology 2008-08-27 Marcus Kaiser , Robert Martin , Peter Andras , Malcolm P. Young

Brain decoding is a hot spot in cognitive science, which focuses on reconstructing perceptual images from brain activities. Analyzing the correlations of collected data from human brain activities and representing activity patterns are two…

Computer Vision and Pattern Recognition · Computer Science 2017-12-06 Siyu Yu , Nanning Zheng , Yongqiang Ma , Hao Wu , Badong Chen

Convolutional neural networks (CNNs) for biomedical image analysis are often of very large size, resulting in high memory requirement and high latency of operations. Searching for an acceptable compressed representation of the base CNN for…

Computer Vision and Pattern Recognition · Computer Science 2019-09-10 Suraj Mishra , Peixian Liang , Adam Czajka , Danny Z. Chen , X. Sharon Hu

High-throughput methods for yielding the set of connections in a neural system, the connectome, are now being developed. This tutorial describes ways to analyze the topological and spatial organization of the connectome at the macroscopic…

Neurons and Cognition · Quantitative Biology 2011-12-23 Marcus Kaiser

Neuroscientists classify neurons into different types that perform similar computations at different locations in the visual field. Traditional methods for neural system identification do not capitalize on this separation of 'what' and…

Machine Learning · Statistics 2018-01-30 David A. Klindt , Alexander S. Ecker , Thomas Euler , Matthias Bethge

Neuronal circuits of the cerebral cortex are the structural basis of mammalian cognition. The same qualitative components and connectivity motifs are repeated across functionally specialized cortical areas and mammalian species, suggesting…

Neurons and Cognition · Quantitative Biology 2025-07-04 Arno Granier , Katharina A Wilmes , Mihai A Petrovici , Walter Senn

Many neuroscientific applications require robust and accurate localization of neurons. It is still an unsolved problem because of the enormous variation in intensity, texture, spatial overlap, morphology and background artifacts. In…

Quantitative Methods · Quantitative Biology 2021-03-22 Tamal Batabyal , Aijaz Ahmad Naik , Daniel Weller , Jaideep Kapur

Brain organoids recapitulate a number of brain properties, including neuronal diversity. However, do they recapitulate brain structure? Using a hydrodynamic description for cell nuclei as particles interacting initially via an effective,…

Soft Condensed Matter · Physics 2021-12-15 Ahmad Borzou , J. M. Schwarz

The neuronal networks in the mammals cortex are characterized by the coexistence of hierarchy, modularity, short and long range interactions, spatial correlations, and topographical connections. Particularly interesting, the latter type of…

Disordered Systems and Neural Networks · Physics 2009-11-10 Luciano da F. Costa , Luis Diambra

The segregation of brain fiber tractography data into distinct and anatomically meaningful clusters can help to comprehend the complex brain structure and early investigation and management of various neural disorders. We propose a novel…

Computer Vision and Pattern Recognition · Computer Science 2017-10-17 Tushar Gupta , Shreyas Malakarjun Patil , Mukkaram Tailor , Daksh Thapar , Aditya Nigam

Networks involved in information processing often have their nodes arranged hierarchically, with the majority of connections occurring in adjacent levels. However, despite being an intuitively appealing concept, the hierarchical…

Neurons and Cognition · Quantitative Biology 2024-07-02 Anand Pathak , Shakti N. Menon , Sitabhra Sinha

Automated detection of curvilinear structures, e.g., blood vessels or nerve fibres, from medical and biomedical images is a crucial early step in automatic image interpretation associated to the management of many diseases. Precise…

Image and Video Processing · Electrical Eng. & Systems 2020-10-20 Lei Mou , Yitian Zhao , Huazhu Fu , Yonghuai Liu , Jun Cheng , Yalin Zheng , Pan Su , Jianlong Yang , Li Chen , Alejandro F Frang , Masahiro Akiba , Jiang Liu

The underlying anatomical structure is fundamental to the study of brain networks, but the role of brainstem from a structural perspective is not very well understood. We conduct a computational and graph-theoretical study of the human…

Neurons and Cognition · Quantitative Biology 2023-04-26 Salma Salhi , Youssef Kora , Gisu Ham , Hadi Zadeh Haghighi , Christoph Simon

The human brain is a complex network of interconnected brain regions organized into functional modules with distinct roles in cognition and behavior. An important question concerns the persistence and stability of these modules over the…

Neurons and Cognition · Quantitative Biology 2015-10-28 Richard F. Betzel , Bratislav Mišić , Ye He , Jeffrey Rumschlag , Xi-Nian Zuo , Olaf Sporns

Despite their success, modern convolutional neural networks (CNNs) exhibit fundamental limitations, including data inefficiency, poor out-of-distribution generalization, and vulnerability to adversarial perturbations. These shortcomings can…

Neural and Evolutionary Computing · Computer Science 2025-11-25 Brennen A. Hill , Zhang Xinyu , Timothy Putra Prasetio

The human brains are organized into hierarchically modular networks facilitating efficient and stable information processing and supporting diverse cognitive processes during the course of development. While the remarkable reconfiguration…

Neurons and Cognition · Quantitative Biology 2020-09-16 Xuyun Wen , Liming Hsu , Weili Lin , Han Zhang , Dinggang Shen

In this paper we propose a deep learning approach for segmenting sub-cortical structures of the human brain in Magnetic Resonance (MR) image data. We draw inspiration from a state-of-the-art Fully-Convolutional Neural Network (F-CNN)…

Computer Vision and Pattern Recognition · Computer Science 2016-02-08 Mahsa Shakeri , Stavros Tsogkas , Enzo Ferrante , Sarah Lippe , Samuel Kadoury , Nikos Paragios , Iasonas Kokkinos

We describe a system to automatically filter clinically significant findings from computerized tomography (CT) head scans, operating at performance levels exceeding that of practicing radiologists. Our system, named DeepRadiologyNet, builds…

Computer Vision and Pattern Recognition · Computer Science 2017-12-05 Jameson Merkow , Robert Lufkin , Kim Nguyen , Stefano Soatto , Zhuowen Tu , Andrea Vedaldi

Understanding the human brain remains the Holy Grail in biomedical science, and arguably in all of the sciences. Our brains represent the most complex systems in the world (and some contend the universe) comprising nearly one hundred…

Quantitative Methods · Quantitative Biology 2016-02-03 Sean L. Simpson , Paul J. Laurienti

Object segmentation and structure localization are important steps in automated image analysis pipelines for microscopy images. We present a convolution neural network (CNN) based deep learning architecture for segmentation of objects in…

Computer Vision and Pattern Recognition · Computer Science 2019-01-24 Shan E Ahmed Raza , Linda Cheung , Muhammad Shaban , Simon Graham , David Epstein , Stella Pelengaris , Michael Khan , Nasir M. Rajpoot