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Modeling genomic sequences faces two unsolved challenges: the information density varies widely across different regions, while there is no clearly defined minimum vocabulary unit. Relying on either four primitive bases or independently…

Genomics · Quantitative Biology 2025-11-20 Siyuan Li , Kai Yu , Anna Wang , Zicheng Liu , Chang Yu , Jingbo Zhou , Qirong Yang , Yucheng Guo , Xiaoming Zhang , Stan Z. Li

Tokenization sits at the boundary between high-throughput genomic input and GPU compute, posing challenges in both algorithm design and system throughput. Overlapping k-mer tokenization can introduce information leakage under masked…

Genomics · Quantitative Biology 2026-01-12 Eliatan Niktab , Hardip Patel

Subword tokenization is a commonly used input pre-processing step in most recent NLP models. However, it limits the models' ability to leverage end-to-end task learning. Its frequency-based vocabulary creation compromises tokenization in…

Computation and Language · Computer Science 2022-04-25 Md Mofijul Islam , Gustavo Aguilar , Pragaash Ponnusamy , Clint Solomon Mathialagan , Chengyuan Ma , Chenlei Guo

We introduce a new tokenizer for language models that minimizes the average tokens per character, thereby reducing the number of tokens needed to represent text during training and to generate text during inference. Our method, which we…

Computation and Language · Computer Science 2025-11-27 Dong Dong , Weijie Su

Although deep learning has advanced automated electrocardiogram (ECG) diagnosis, prevalent supervised methods typically treat recordings as undifferentiated one-dimensional (1D) signals or two-dimensional (2D) images. This formulation…

Machine Learning · Computer Science 2026-01-13 Runze Ma , Caizhi Liao

Signature kernels have emerged as a powerful tool within kernel methods for sequential data. In the paper "The Signature Kernel is the solution of a Goursat PDE", the authors identify a kernel trick that demonstrates that, for continuously…

Numerical Analysis · Mathematics 2026-01-19 Thomas Cass , Francesco Piatti , Jeffrey Pei

Recent advancements in large language models (LLMs) have remarkably enhanced performances on a variety of tasks in multiple languages. However, tokenizers in LLMs trained primarily on English-centric corpora often overly fragment a text…

Computation and Language · Computer Science 2024-08-07 Jimin Hong , Gibbeum Lee , Jaewoong Cho

Adapting language models to new data distributions by simple finetuning is challenging. This is due to the rigidity of their subword tokenizers, which typically remain unchanged during adaptation. This inflexibility often leads to…

Computation and Language · Computer Science 2026-05-14 Abraham Toluwase Owodunni , Orevaoghene Ahia , Sachin Kumar

In autoregressive (AR) image generation, visual tokenizers compress images into compact discrete latent tokens, enabling efficient training of downstream autoregressive models for visual generation via next-token prediction. While scaling…

Computer Vision and Pattern Recognition · Computer Science 2025-08-26 Tianwei Xiong , Jun Hao Liew , Zilong Huang , Jiashi Feng , Xihui Liu

Symbolic regression via genetic programming is a flexible approach to machine learning that does not require up-front specification of model structure. However, traditional approaches to symbolic regression require the use of protected…

Neural and Evolutionary Computing · Computer Science 2017-04-18 Grant Dick

Learning meaningful representations from medical time series (MedTS) such as ECG or EEG signals is a critical challenge. These signals are often high-dimensional, variable-length and rife with noise. Existing self-supervised approaches,…

Machine Learning · Computer Science 2026-05-04 Huayu Li , ZhengXiao He , Xiwen Chen , Jingjing Wang , Siyuan Tian , Jinghao Wen , Ao Li

Artificial intelligence (AI) is increasingly central to understanding how the brain processes information. However, the integration of neuroscience and modern AI is bottlenecked by a fragmented software ecosystem. Current tools are siloed…

Recent breakthroughs in natural language processing and computer vision, driven by efficient pre-training on large datasets, have enabled foundation models to excel on a wide range of tasks. However, this potential has not yet been fully…

Machine Learning · Computer Science 2025-02-03 Özgün Turgut , Philip Müller , Martin J. Menten , Daniel Rueckert

Image tokenizers form the foundation of modern text-to-image generative models but are notoriously difficult to train. Furthermore, most existing text-to-image models rely on large-scale, high-quality private datasets, making them…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Dongwon Kim , Ju He , Qihang Yu , Chenglin Yang , Xiaohui Shen , Suha Kwak , Liang-Chieh Chen

Motivation: The comparison of diverse genomic datasets is fundamental to understanding genome biology. Researchers must explore many large datasets of genome intervals (e.g., genes, sequence alignments) to place their experimental results…

Genomics · Quantitative Biology 2012-08-20 Ryan M. Layer , Kevin Skadron , Gabriel Robins , Ira M. Hall , Aaron R. Quinlan

Recurrent neural networks (RNNs) with deep test-time memorization modules, such as Titans and TTT, represent a promising, linearly-scaling paradigm distinct from Transformers. While these expressive models do not yet match the peak…

Machine Learning · Computer Science 2025-11-11 Zeman Li , Ali Behrouz , Yuan Deng , Peilin Zhong , Praneeth Kacham , Mahdi Karami , Meisam Razaviyayn , Vahab Mirrokni

One of the most striking findings in modern research on large language models (LLMs) is that scaling up compute during training leads to better results. However, less attention has been given to the benefits of scaling compute during…

Computation and Language · Computer Science 2024-11-21 Sean Welleck , Amanda Bertsch , Matthew Finlayson , Hailey Schoelkopf , Alex Xie , Graham Neubig , Ilia Kulikov , Zaid Harchaoui

Low-cost, high-throughput DNA and RNA sequencing (HTS) data is the backbone of the life sciences. Genome sequencing is now becoming a part of Predictive, Preventive, Personalized, and Participatory (termed 'P4') medicine. All genomic data…

Discrete tokenizers have emerged as indispensable components in modern machine learning systems, particularly within the context of autoregressive modeling and large language models (LLMs). These tokenizers serve as the critical interface…

Information Retrieval · Computer Science 2025-02-19 Jian Jia , Jingtong Gao , Ben Xue , Junhao Wang , Qingpeng Cai , Quan Chen , Xiangyu Zhao , Peng Jiang , Kun Gai

This paper presents a comprehensive study on the tokenization techniques employed by state-of-the-art large language models (LLMs) and their implications on the cost and availability of services across different languages, especially low…

Computation and Language · Computer Science 2024-10-07 Abrar Rahman , Garry Bowlin , Binit Mohanty , Sean McGunigal
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