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Accurate and efficient modeling of cardiac blood flow is crucial for advancing data-driven tools in cardiovascular research and clinical applications. Recently, the accuracy and availability of computational fluid dynamics (CFD)…

Fluid Dynamics · Physics 2025-07-30 Eneko Lazpita , Jesus Garicano-Mena , Soledad Le Clainche

Mechano-electric feedbacks (MEFs), which model how mechanical stimuli are transduced into electrical signals, have received sparse investigation by considering electromechanical simulations in simplified scenarios. In this paper, we study…

Numerical Analysis · Mathematics 2021-11-01 Matteo Salvador , Francesco Regazzoni , Stefano Pagani , Luca Dede' , Natalia Trayanova , Alfio Quarteroni

Numerical simulations to evaluate thoracic aortic hemodynamics include a computational fluid dynamic (CFD) approach or fluid-structure interaction (FSI) approach. While CFD neglects the arterial deformation along the cardiac cycle by…

Cardiovascular diseases (CVDs) are the number one cause of death worldwide. While there is growing evidence that the atrial fibrillation (AF) has strong associations with various CVDs, this heart arrhythmia is usually diagnosed using…

Systems and Control · Electrical Eng. & Systems 2022-07-13 Wei-Ying Yi , Peng-Fei Liu , Sheung-Lai Lo , Ya-Fen Chan , Yu Zhou , Yee Leung , Kam-Sang Woo , Alex Pui-Wai Lee , Jia-Min Chen , Kwong-Sak Leung

Aims. Clinical data indicating a heart rate (HR) target during rate control therapy for permanent atrial fibrillation (AF) and assessing its eventual relationship with reduced exercise tolerance are lacking. The present study aims at…

Medical Physics · Physics 2017-01-17 Matteo Anselmino , Stefania Scarsoglio , Andrea Saglietto , Fiorenzo Gaita , Luca Ridolfi

Atrial fibrillation (AF) is the most common arrhythmia affecting millions of people in the Western countries and, due to the widespread impact on the population and its medical relevance, is largely investigated in both clinical and…

Medical Physics · Physics 2014-09-12 Stefania Scarsoglio , Andrea Guala , Carlo Camporeale , Luca Ridolfi

Computer models of cardiac electro-mechanics (EM) show promise as an effective means for quantitative analysis of clinical data and, potentially, for predicting therapeutic responses.realize such advanced applications methodological key…

Mathematical models are widely recognized as a valuable tool for cardiovascular diagnosis and the study of circulatory diseases, especially to obtain data that require otherwise invasive measurements. To correctly simulate body…

Computational fluid dynamics (CFD) models are emerging as tools for assisting in diagnostic assessment of cardiovascular disease. Recent advances in image segmentation has made subject-specific modelling of the cardiovascular system a…

Quantitative Methods · Quantitative Biology 2021-01-18 Mitchel J. Colebank , L. Mihaela Paun , M. Umar Qureshi , Naomi Chesler , Dirk Husmeier , Mette S. Olufsen , Laura Ellwein Fix

Image-based modeling is essential for understanding cardiovascular hemodynamics and advancing the diagnosis and treatment of cardiovascular diseases. Constructing patient-specific vascular models remains labor-intensive, error-prone, and…

Computer Vision and Pattern Recognition · Computer Science 2025-03-18 Pan Du , Delin An , Chaoli Wang , Jian-Xun Wang

Cardiovascular diseases are a leading cause of death in the world, driving the development of patient-specific and benchmark models for blood flow analysis. This chapter provides a theoretical overview of the main categories of Reduced…

Numerical Analysis · Mathematics 2025-10-21 Pierfrancesco Siena , Pasquale Claudio Africa , Michele Girfoglio , Gianluigi Rozza

The numerical tools to simulate the bidomain model in cardiac electrophysiology are constantly developing due to the great clinical interest and scientific advances in mathematical models and computational power. The bidomain model consists…

Numerical Analysis · Mathematics 2025-11-03 Gopika P B , Peter Bastian , Nagaiah Chamakuri

Cardiovascular hemodynamic fields provide valuable medical decision markers for coronary artery disease. Computational fluid dynamics (CFD) is the gold standard for accurate, non-invasive evaluation of these quantities in silico. In this…

Quantitative Methods · Quantitative Biology 2025-08-27 Julian Suk , Guido Nannini , Patryk Rygiel , Christoph Brune , Gianluca Pontone , Alberto Redaelli , Jelmer M. Wolterink

Conventional cardiovascular magnetic resonance (CMR) cine imaging relies on binning multiple heartbeats into a single cardiac cycle, which fails in arrhythmic patients where beat-to-beat variability causes motion artifacts and loss of…

Valvular heart diseases are growing concern in impoverished parts of the world, such as Southern-Africa, claiming more than 31 % of total deaths related to cardiovascular diseases. The ability to model the effects of regurgitant and…

Medical Physics · Physics 2022-04-11 Ryno Laubscher , Jacques Liebenberg , Philip Herbst

Background. Despite the routine prescription of rate control therapy for atrial fibrillation (AF), clinical evidence demonstrating a heart rate target is lacking. Aim of the present study was to run a mathematical model simulating AF…

Objectives: The main objective of this review article is to evaluate the usability of Computational Fluid Dynamics (CFD) as a supporting clinical tool for respiratory system. Data Source: The English articles referred for this review paper…

Fluid Dynamics · Physics 2023-10-24 Rajneesh Kashyap , R. Thundil Karuppa Raj

Coronary arteries and their branches supply blood to myocardium. The obstruction of coronary arteries results in significant loss of myocardium, called acute myocardial infarction, and the number one cause of death globally. Hence,…

Computational Geometry · Computer Science 2017-08-31 Jehyun Chaa , Joonghyun Ryub , Jin-Ho Choi , Deok-Soo Kim

The left ventricular assist device (LVAD) has been used for end-stage heart failure patients as a therapeutic option. The aortic valve plays a critical role in heart failure and its treatment with LVAD. The cardiovascular-LVAD model is…

Tissues and Organs · Quantitative Biology 2018-12-19 Jeongeun Son , Dongping Du , Yuncheng Du

Three-dimensional cardiovascular fluid dynamics simulations typically require computation of several cardiac cycles before they reach a periodic solution, rendering them computationally expensive. Furthermore, there is currently no…

Computational Engineering, Finance, and Science · Computer Science 2021-06-28 Martin R. Pfaller , Jonathan Pham , Nathan M. Wilson , David W. Parker , Alison L. Marsden