Related papers: Near-perfect efficiency in X-ray phase microtomogr…
We implement a general imaging method by measuring the complex degree of coherence using linear optics and photon number resolving detectors. In the absence of collective or entanglement assisted measurements, our method is optimal over a…
In situ synchrotron X-ray computed tomography enables dynamic material studies. However, automated segmentation remains challenging due to complex imaging artefacts - like ring and cupping effects - and limited training data. We present a…
Particle beams focused to micrometer-sized spots play a crucial role in forefront research using low-energy positrons. Their expedient and wide application, however, requires highly-resolved, fast beam diagnostics. We have developed two…
State-of-the-art microscopes use intense lasers that can severely disturb biological processes, function and viability. This introduces hard limits on performance that only quantum photon correlations can overcome. Here we demonstrate this…
The problem of optimization of propagation-based phase-contrast imaging setups is considered in the case of projection X-ray imaging and three-dimensional tomography with phase retrieval. For two-dimensional imaging, a simple model for a…
The observation of fast physical dynamics using optical techniques currently relies on indirect methods, such as pump-probe measurements. One reason for this is the lack of an efficient detector with high time resolution. Single-photon…
The hyperspectral X-ray imaging has been long sought in various fields from material analysis to medical diagnosis. Here we propose a new semiconductor detector structure to realize energy-resolved imaging at potentially low cost. The…
We describe a method aiming at increasing the dynamic range of X-ray detectors. Two X-ray exposures of an object are acquired at different dose levels and constitute the only input data. The values of the parameters which are needed to…
X-ray near field holography has proven to be a powerful 2D and 3D imaging technique with applications ranging from biomedical research to material sciences. To reconstruct meaningful and quantitative images from the measurement intensities,…
Coherent X-ray diffraction microscopy is a method of imaging non-periodic isolated objects at resolutions only limited, in principle, by the largest scattering angles recorded. We demonstrate X-ray diffraction imaging with high resolution…
X-ray microtomography is a powerful non-destructive technique allowing 3D virtual histology of resected human tissue. The achievable imaging field-of-view, is however limited by the fixed number of detector elements, enforcing the…
X-ray 3D tomography is So far limited to micron resolution because of the large focusing spot of the focused electron beam on the metal target. Here, we proposed a nanofocous X-ray 3D tomography system based on focused electrons from…
Cryo-Electron Microscopy (cryo-EM) has become an extremely powerful method for resolving structural details of large biomolecular complexes. However, challenging problems in single-particle methods remain open because of (1) the low…
Given the crucial role of microtubules for cell survival, many researchers have found success using microtubule-targeting agents in the search for effective cancer therapeutics. Understanding microtubule responses to targeted interventions…
Established x-ray diffraction methods allow for high-resolution structure determination of crystals, crystallized protein structures or even single molecules. While these techniques rely on coherent scattering, incoherent processes like…
Two-dimensional Talbot array illuminators (TAIs) were designed, fabricated, and evaluated for high-resolution high-contrast x-ray phase imaging of soft tissue at 10-20keV. The TAIs create intensity modulations with a high compression ratio…
We report both sub-diffraction-limited quantum metrology and quantum enhanced spatial resolution for the first time in a biological context. Nanoparticles are tracked with quantum correlated light as they diffuse through an extended region…
Experimental protocols at synchrotron light sources typically process and validate data only after an experiment has completed, which can lead to undetected errors and cannot enable online steering. Real-time data analysis can enable both…
Synchrotron radiation with the characteristic of high brilliance, high level of polarization, high collimation, low emittance and wide tunability in energy has been used as a standard source in metrology(1, 2). For a decade, lots of…
Biological soft tissues encountered in clinical and pre-clinical imaging mainly consist of light element atoms, and their composition is nearly uniform with little density variation. Thus, x-ray attenuation imaging suffers from low image…