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The energy range of hard X-rays is a key waveband to the study of high energy processes in celestial objects, but still remains poorly explored. In contrast to direct imaging methods used in the low energy X-ray and high energy gamma-ray…

Astrophysics · Physics 2007-05-23 T. P. Li

Two-directional beam-tracking (2DBT) is a method for phase-contrast imaging and tomography that uses an intensity modulator to structure the X-ray beam into an array of independent circular beamlets that are resolved by a high-resolution…

Super-resolution microscopy is crucial for imaging sub-wavelength biological structures. However, most techniques rely on nonlinear saturation or stochastic switching of emitters, limiting imaging speed and increasing phototoxicity. Here,…

The penetration power of x-rays allows one to image large objects. For example, centimeter-sized specimens can be imaged with micron-level resolution using synchrotron sources. In this case, however, the limited beam diameter and detector…

Image and Video Processing · Electrical Eng. & Systems 2020-12-23 Ming Du , Rafael Vescovi , Kamel Fezzaa , Chris Jacobsen , Doga Gursoy

We demonstrate a new computational illumination technique that achieves large space-bandwidth-time product, for quantitative phase imaging of unstained live samples in vitro. Microscope lenses can have either large field of view (FOV) or…

Optics · Physics 2015-10-16 Lei Tian , Ziji Liu , Li-Hao Yeh , Michael Chen , Jingshan Zhong , Laura Waller

Melanoma detection is vital for early diagnosis and effective treatment. While deep learning models on dermoscopic images have shown promise, they require specialized equipment, limiting their use in broader clinical settings. This study…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Volodymyr Sydorskyi , Igor Krashenyi , Oleksii Yakubenko

Clinical biosensors with low detection limit hold significant promise in the early diagnosis of debilitating diseases. Recent progress in sensor development has led to the demonstration of detection capable of detecting target molecules…

Medical Physics · Physics 2019-12-05 Tuhin Chakrabortty , Chandra R. Murthy , Manoj Varma

Laser wakefield acceleration of electrons represents a basis for several types of novel X-ray sources based on Thomson scattering or betatron radiation. The latter provides a high photon flux and a small source size, both being…

Medical Physics · Physics 2018-12-26 J. Götzfried , A. Döpp , M. Gilljohann , H. Ding , S. Schindler , J. Wenz , L. Hehn , F. Pfeiffer , S. Karsch

One of the great challenges in biology is to observe, at sufficient detail, the real-time workings of the cell. Many methods exist to do cell measurements invasively. For example, mass spectrometry has tremendous mass sensitivity but…

Quantitative Methods · Quantitative Biology 2017-10-23 Jan G. Korvink , Neil MacKinnon

Recovering both amplitude and phase information from a system is a fundamental goal of optical imaging. At the same time, it is crucial to operate at low photon doses to avoid altering the sample, particularly in biological applications.…

Quantum Physics · Physics 2026-01-15 Alberto Paniate , Giuseppe Ortolano , Sarika Soman , Marco Genovese , Ivano Ruo-Berchera

Proper X-ray radiation design (via dynamic fluence field modulation, FFM) allows to reduce effective radiation dose in computed tomography without compromising image quality. It takes into account patient anatomy, radiation sensitivity of…

Medical Physics · Physics 2024-01-02 Anatoli Juditsky , Arkadi Nemirovski , Michael Zibulevsky

We propose an imaging system and methodology for mapping soft-tissue samples in three dimensions, with micron-scale and isotropic spatial resolution, with low-concentrations as well as in the absence of heavy metal staining. We used hard…

Instrumentation and Detectors · Physics 2023-12-21 Michela Esposito , Nicole Schieber , Alessandro Olivo , Yannick Schwab , Marco Endrizzi

X-ray Multi-Projection Imaging (XMPI) is an emerging technology that allows for the acquisition of millions of 3D images per second in samples opaque to visible light. This breakthrough capability enables volumetric observation of fast…

To take advantage of high-resolution optics sensitive to a broad energy range, future X-ray imaging instruments will require thick detectors with small pixels. This pixel aspect ratio affects spectral response in the soft X-ray band, vital…

High energy radiations are nowadays cornerstone in scientific, medical and industrial imaging and cancer therapy. However, their detection and dosimetry are restricted to systems of modest compactness that are not compatible with endoscopy.…

A simple imaging system together with complex semidefinite programming is used to generate the transmission matrix of a multimode fiber. Once the transmission matrix is acquired, we can modulate the phase of the input signal to induce…

Coherent diffractive imaging is unique as the only route for achieving diffraction-limited spatial resolution in the extreme ultraviolet and X-ray regions, limited only by the wavelength of the light. Recently, advances in coherent short…

We report an angle-tilted, wavelength-multiplexed ptychographic modulation approach for multispectral lensless on-chip microscopy. In this approach, we illuminate the specimen with lights at 5 wavelengths simultaneously. A prism is added at…

The challenge of imaging low-density objects in an electron microscope without causing beam damage is significant in modern TEM. This is especially true for life science imaging, where the sample, rather than the instrument, still…

Optics · Physics 2025-01-29 Francisco Vega Ibáñez , Jo Verbeeck