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Patient recruitment remains a major bottleneck in clinical trials, calling for scalable and automated solutions. We present TrialMatchAI, an AI-powered recommendation system that automates patient-to-trial matching by processing…

AI is poised to revolutionize telecommunication networks by boosting efficiency, automation, and decision-making. However, the black-box nature of most AI models introduces substantial risk, possibly deterring adoption by network operators.…

Information Theory · Computer Science 2025-04-29 Osvaldo Simeone , Sangwoo Park , Matteo Zecchin

In AI-driven medical imaging, the failure to detect out-of-distribution (OOD) data poses a severe risk to clinical reliability, potentially leading to critical diagnostic errors. Current OOD detection methods often demand impractical…

Computer Vision and Pattern Recognition · Computer Science 2026-04-17 Dariush Lotfi , Mohammad-Ali Nikouei Mahani , Mohamad Koohi-Moghadam , Kyongtae Ty Bae

Artificial intelligence (AI) is increasingly used in clinical settings, yet limited oversight and domain expertise can allow algorithmic bias and safety risks to persist. This study evaluates whether an agentic AI system can support…

Drug resistance is still a major challenge in cancer therapy. Drug combination is expected to overcome drug resistance. However, the number of possible drug combinations is enormous, and thus it is infeasible to experimentally screen all…

Genomics · Quantitative Biology 2018-11-20 Tianyu Zhang , Liwei Zhang , Philip R. O. Payne , Fuhai Li

Modern Artificial Intelligence (AI) increasingly relies on multi-agent architectures that blend visual and language understanding. Yet, a pressing challenge remains: How can we trust these agents especially in zero-shot settings with no…

Artificial Intelligence · Computer Science 2025-09-23 Konstantinos I. Roumeliotis , Ranjan Sapkota , Manoj Karkee , Nikolaos D. Tselikas

Background: The surge in single-cell omics data exposes limitations in traditional, manually defined analysis workflows. AI agents offer a paradigm shift, enabling adaptive planning, executable code generation, traceable decisions, and…

Genomics · Quantitative Biology 2026-03-17 Yang Liu , Lu Zhou , Xiawei Du , Ruikun He , Xuguang Zhang , Rongbo Shen , Yixue Li

Artificial intelligence (AI) systems increasingly match or surpass human experts in biomedical signal interpretation. However, their effective integration into clinical practice requires more than high predictive accuracy. Clinicians must…

Machine Learning · Computer Science 2025-10-27 Stefan Kraft , Andreas Theissler , Vera Wienhausen-Wilke , Gjergji Kasneci , Hendrik Lensch

Background: Clinical prediction models for a health condition are commonly evaluated regarding performance for a population, although decisions are made for individuals. The classic view relates uncertainty in risk estimates for individuals…

There is an intuitive analogy of an organic chemist's understanding of a compound and a language speaker's understanding of a word. Consequently, it is possible to introduce the basic concepts and analyze potential impacts of linguistic…

Machine Learning · Computer Science 2017-11-16 Philippe Schwaller , Theophile Gaudin , David Lanyi , Costas Bekas , Teodoro Laino

Background: Medical decision-making impacts both individual and public health. Clinical scores are commonly used among a wide variety of decision-making models for determining the degree of disease deterioration at the bedside. AutoScore…

We present our winning solution to the SIIM-ISIC Melanoma Classification Challenge. It is an ensemble of convolutions neural network (CNN) models with different backbones and input sizes, most of which are image-only models while a few of…

Computer Vision and Pattern Recognition · Computer Science 2020-10-13 Qishen Ha , Bo Liu , Fuxu Liu

Optical proximity correction (OPC) is a widely-used resolution enhancement technique (RET) for printability optimization. Recently, rigorous numerical optimization and fast machine learning are the research focus of OPC in both academia and…

Computer Vision and Pattern Recognition · Computer Science 2023-03-23 Wenqian Zhao , Xufeng Yao , Ziyang Yu , Guojin Chen , Yuzhe Ma , Bei Yu , Martin D. F. Wong

Artificial intelligence (AI) systems are increasingly integrated into healthcare and pharmacy workflows, supporting tasks such as medication recommendations, dosage determination, and drug interaction detection. While these systems often…

Artificial Intelligence · Computer Science 2026-05-21 Khalid Adnan Alsayed

Inverse Optimal Control (IOC) aims to infer the underlying cost functional of an agent from observations of its expert behavior. This paper focuses on the IOC problem within the continuous-time linear quadratic regulator framework,…

Optimization and Control · Mathematics 2025-07-29 Meiling Yu , Lechen Feng , Lei Jiang , Yuan-Hua Ni

Research waste in biomedical science is driven by redundant studies, incomplete reporting, and the limited scalability of traditional evidence synthesis workflows. We present an AI co-scientist for scalable and transparent knowledge…

Artificial Intelligence · Computer Science 2026-01-21 Arya Rahgozar , Pouria Mortezaagha

In communication and computation cooperative networks (3CNs), timely computation is crucial but not always guaranteed. There is a strong demand for a computational task to be completed within a given deadline. The time taken involves both…

Systems and Control · Electrical Eng. & Systems 2025-06-24 Xingran Chen , Yi Zhuang , Kun Yang

We propose orthogonal inductive matrix completion (OMIC), an interpretable approach to matrix completion based on a sum of multiple orthonormal side information terms, together with nuclear-norm regularization. The approach allows us to…

Machine Learning · Computer Science 2021-08-26 Antoine Ledent , Rodrigo Alves , Marius Kloft

Ensuring persona fidelity in large language models (LLMs) is essential for maintaining coherent and engaging human-AI interactions. However, LLMs often exhibit Out-of-Character (OOC) behavior, where generated responses deviate from an…

Computation and Language · Computer Science 2025-06-25 Jisu Shin , Juhyun Oh , Eunsu Kim , Hoyun Song , Alice Oh

Foundation models are increasingly applied to computational pathology, yet their behavior under cross-cancer and cross-species transfer remains unspecified. This study investigated how fine-tuning CPath-CLIP affects cancer detection under…

Computer Vision and Pattern Recognition · Computer Science 2026-03-06 Ekansh Arora