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The integration of artificial intelligence (AI) into medicine is remarkable, offering advanced diagnostic and therapeutic possibilities. However, the inherent opacity of complex AI models presents significant challenges to their clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Binbin Wen , Yihang Wu , Tareef Daqqaq , Ahmad Chaddad

Despite strong performance in audio perception tasks, large audio-language models (AudioLLMs) remain opaque to interpretation. A major factor behind this lack of interpretability is that individual neurons in these models frequently…

Sound · Computer Science 2026-02-27 Townim Faisal Chowdhury , Ta Duc Huy , Siqi Pan , Jeremy Stoddard , Zhibin Liao

Clinical decision making is challenging because of pathological complexity, as well as large amounts of heterogeneous data generated as part of routine clinical care. In recent years, machine learning tools have been developed to aid this…

Sparse autoencoders (SAEs) have emerged as a powerful tool for interpreting large language models (LLMs) by decomposing token activations into combinations of human-understandable features. While SAEs provide crucial insights into LLM…

Machine Learning · Computer Science 2025-11-11 Zhen Xu , Zhen Tan , Song Wang , Kaidi Xu , Tianlong Chen

Intermediate layers of large language models (LLMs) best predict human brain responses to language, one of the most robust findings in computational neurolinguistics, yet why remains mechanistically unexplained. We address this gap by…

Computation and Language · Computer Science 2026-05-25 Dongxin Guo , Jikun Wu , Siu Ming Yiu

Sparse autoencoders (SAEs) have proven useful in disentangling the opaque activations of neural networks, primarily large language models, into sets of interpretable features. However, adapting them to domains beyond language, such as…

Machine Learning · Computer Science 2025-11-13 Ege Erdogan , Ana Lucic

Sparse autoencoders (SAEs) have been used widely to decompose and interpret neural network activations, especially those of transformer language models. One key issue with SAEs is their inability to directly model multidimensional features.…

Machine Learning · Computer Science 2026-05-12 Collin Francel

Sparse Autoencoders (SAEs) are widely employed for mechanistic interpretability and model steering. Within this context, steering is by design performed by means of decoding altered SAE intermediate representations. This procedure…

Machine Learning · Computer Science 2025-12-08 Antonio Bărbălau , Cristian Daniel Păduraru , Teodor Poncu , Alexandru Tifrea , Elena Burceanu

Translating the internal representations and computations of models into concepts that humans can understand is a key goal of interpretability. While recent dictionary learning methods such as Sparse Autoencoders (SAEs) provide a promising…

Computation and Language · Computer Science 2026-02-27 Usha Bhalla , Alex Oesterling , Claudio Mayrink Verdun , Himabindu Lakkaraju , Flavio P. Calmon

Understanding the internal representations of large language models (LLMs) remains a central challenge for interpretability research. Sparse autoencoders (SAEs) offer a promising solution by decomposing activations into interpretable…

Machine Learning · Computer Science 2025-10-10 Yifei Yao , Mengnan Du

We present a method for extracting \emph{monosemantic} neurons, defined as latent dimensions that align with coherent and interpretable concepts, from user and item embeddings in recommender systems. Our approach employs a Sparse…

Information Retrieval · Computer Science 2025-11-25 Dor Arviv , Yehonatan Elisha , Oren Barkan , Noam Koenigstein

Robust tooling and publicly available pre-trained models have helped drive recent advances in mechanistic interpretability for language models. However, similar progress in vision mechanistic interpretability has been hindered by the lack…

Computer Vision and Pattern Recognition · Computer Science 2025-06-04 Sonia Joseph , Praneet Suresh , Lorenz Hufe , Edward Stevinson , Robert Graham , Yash Vadi , Danilo Bzdok , Sebastian Lapuschkin , Lee Sharkey , Blake Aaron Richards

Sparse autoencoders (SAEs) have recently become central tools for interpretability, leveraging dictionary learning principles to extract sparse, interpretable features from neural representations whose underlying structure is typically…

Machine Learning · Computer Science 2025-11-05 Valérie Costa , Thomas Fel , Ekdeep Singh Lubana , Bahareh Tolooshams , Demba Ba

Sparse autoencoders (SAEs) are a popular method for interpreting concepts represented in large language model (LLM) activations. However, there is a lack of evidence regarding the validity of their interpretations due to the lack of a…

Machine Learning · Computer Science 2025-02-25 Subhash Kantamneni , Joshua Engels , Senthooran Rajamanoharan , Max Tegmark , Neel Nanda

Sparse autoencoders (SAEs) offer a natural path toward comparable explanations across different representation spaces. However, current SAEs are trained per modality, producing dictionaries whose features are not directly understandable and…

Computer Vision and Pattern Recognition · Computer Science 2026-02-10 Difei Gu , Yunhe Gao , Gerasimos Chatzoudis , Zihan Dong , Guoning Zhang , Bangwei Guo , Yang Zhou , Mu Zhou , Dimitris Metaxas

Deep learning, particularly with the advancement of Large Language Models, has transformed biomolecular modeling, with protein language models such as ESM inspiring emerging RNA language models such as RiNALMo. Recent work has begun…

Biomolecules · Quantitative Biology 2026-05-18 Taehan Kim , Sangdae Nam

Medical vision-and-language pre-training provides a feasible solution to extract effective vision-and-language representations from medical images and texts. However, few studies have been dedicated to this field to facilitate medical…

Computer Vision and Pattern Recognition · Computer Science 2022-09-16 Zhihong Chen , Yuhao Du , Jinpeng Hu , Yang Liu , Guanbin Li , Xiang Wan , Tsung-Hui Chang

We propose a selective learning method using meta-learning and deep reinforcement learning for medical image interpretation in the setting of limited labeling resources. Our method, MedSelect, consists of a trainable deep learning selector…

Computer Vision and Pattern Recognition · Computer Science 2021-03-29 Akshay Smit , Damir Vrabac , Yujie He , Andrew Y. Ng , Andrew L. Beam , Pranav Rajpurkar

The high-level concepts that a neural network uses to perform computation need not be aligned to individual neurons (Smolensky, 1986). Language model interpretability research has thus turned to techniques such as \textit{sparse…

Computation and Language · Computer Science 2026-02-02 Aryaman Arora , Zhengxuan Wu , Jacob Steinhardt , Sarah Schwettmann

This study presents Latent Diffusion Autoencoder (LDAE), a novel encoder-decoder diffusion-based framework for efficient and meaningful unsupervised learning in medical imaging, focusing on Alzheimer disease (AD) using brain MR from the…

Computer Vision and Pattern Recognition · Computer Science 2026-01-12 Gabriele Lozupone , Alessandro Bria , Francesco Fontanella , Frederick J. A. Meijer , Claudio De Stefano , Henkjan Huisman
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